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@article{1823960,
author = {Doležalová, Lenka and Bláhová, Lucie and Kuta, Jan and Hojdarová, Tereza and Kozáková, Šárka and Bláha, Luděk},
article_location = {Heidelberg},
article_number = {18},
doi = {http://dx.doi.org/10.1007/s11356-021-17607-y},
keywords = {Surface contamination; Occupational exposure; Antineoplastic drugs; Hospital pharmacy; 5-fluorouracil; Cyclophosphamide; Platinum derivatives; Gemcitabine},
language = {eng},
issn = {0944-1344},
journal = {Environmental Science and Pollution Research},
title = {Levels and risks of surface contamination by thirteen antineoplastic drugs in the Czech and Slovak hospitals and pharmacies},
url = {https://link.springer.com/article/10.1007%2Fs11356-021-17607-y},
volume = {29},
year = {2022}
}
TY - JOUR
ID - 1823960
AU - Doležalová, Lenka - Bláhová, Lucie - Kuta, Jan - Hojdarová, Tereza - Kozáková, Šárka - Bláha, Luděk
PY - 2022
TI - Levels and risks of surface contamination by thirteen antineoplastic drugs in the Czech and Slovak hospitals and pharmacies
JF - Environmental Science and Pollution Research
VL - 29
IS - 18
SP - 26810-26819
EP - 26810-26819
PB - Springer Heidelberg
SN - 09441344
KW - Surface contamination
KW - Occupational exposure
KW - Antineoplastic drugs
KW - Hospital pharmacy
KW - 5-fluorouracil
KW - Cyclophosphamide
KW - Platinum derivatives
KW - Gemcitabine
UR - https://link.springer.com/article/10.1007%2Fs11356-021-17607-y
N2 - The consumption of hazardous antineoplastic drugs (ADs) used in anticancer chemotherapies is steadily increasing representing thus risks to both human health and the environment. Hospitals may serve as a contamination source, and pharmacists preparing the antineoplastic drugs (ADs) as well as nurses administering chemotherapy and caring for oncology patients are among the healthcare professionals being highly exposed. Here, we present the results of systematic monitoring (2018-2020) of surface contamination by 13 ADs in the pharmacies and hospitals in the Czech Republic (CZ; large-scale monitoring, 20 workplaces) and Slovak Republic (SK; pilot study at 4 workplaces). The study evaluated contamination by three commonly monitored ADs, i.e., 5-fluorouracil (FU), cyclophosphamide (CP), and platinum (total Pt representing cis-, carbo-, and oxaliplatin) together with ten less explored ADs, i.e., gemcitabine (GEM), ifosfamide (IF), paclitaxel (PX), irinotecan (IRI), docetaxel (DOC), methotrexate (MET), etoposide (ETOP), capecitabine (CAP), imatinib (IMAT), and doxorubicin (DOX). Floors and desktop surfaces in hospitals (chemotherapy application rooms, nurse working areas) were found to be more contaminated, namely with CP and Pt, in both countries when compared to pharmacies. Comparison between the countries showed that hospital surfaces in SK are generally more contaminated (e.g., CP median was 20 times higher in SK), while some pharmacy areas in the CZ were more contamined in comparison with SK. The newly studied ADs were detected at lower concentrations in comparison to FU, CP, and Pt, but some markers (GEM, IF, PX, and IRI) were frequently observed, and adding these compounds to routine monitoring is recommended.
ER -
DOLEŽALOVÁ, Lenka, Lucie BLÁHOVÁ, Jan KUTA, Tereza HOJDAROVÁ, Šárka KOZÁKOVÁ and Luděk BLÁHA. Levels and risks of surface contamination by thirteen antineoplastic drugs in the Czech and Slovak hospitals and pharmacies (Levels and risks of surface contamination by thirteen antineoplastic drugs in the Czech and Slovak hospitals and pharmacies. Environmental Science and Pollution Research). \textit{Environmental Science and Pollution Research}. Heidelberg: Springer Heidelberg, 2022, vol.~29, No~18, p.~26810-26819. ISSN~0944-1344. Available from: https://dx.doi.org/10.1007/s11356-021-17607-y.
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