J 2022

COVID-19 pandemic, mechanical reperfusion and 30-day mortality in ST elevation myocardial infarction

DE LUCA, G., M. ALGOWHARY, B. UGUZ, D. C. OLIVEIRA, V. GANYUKOV et. al.

Basic information

Original name

COVID-19 pandemic, mechanical reperfusion and 30-day mortality in ST elevation myocardial infarction

Authors

DE LUCA, G. (guarantor), M. ALGOWHARY, B. UGUZ, D. C. OLIVEIRA, V. GANYUKOV, Z. ZIMBAKOV, M. CERCEK, L. O. JENSEN, P.H . LOH, L. CALMAC, G. ROURA-FERRER, A. QUADROS, M. MILEWSKI, F. SCOTTO DI UCCIO, C. VON BIRGELEN, F. VERSACI, J. TEN BERG, G. CASELLA, A. S. L. WONG, Petr KALA (203 Czech Republic, belonging to the institution), J. L. DIEZ GIL, X. CARRILLO, M. T. DIRKSEN, VM. BECERRA-MUÑOZ, M. KANG-YIN LEE, D. A. JUZAR, R. DE MOURA JOAQUIM, R. PALADINO, D. MILICIC, P. DAVLOUROS, N. BAKRACESKI, F. ZILIO, L. DONAZZAN, A. O. KRAAIJEVELD, G. GALASSO, A. LUX, L. MARINUCCI, V. GUIDUCCI, M. MENICHELLI, A. SCOCCIA, A. YAMAC, K. UGUR MERT, X. FLORES RIOS, T. KOVARNIK, M. KIDAWA, J. MOREU, V. FLAVIEN, E. FABRIS, I. LOZANO MARTÌNEZ-LUENGAS, M. BOCCALATTE, F. BOSA OJEDA, C. ARELLANO-SERRANO, G. CAIAZZO, G. CIRRINCIONE, H. L. KAO, J. SANCHIS FORES, L. VIGNALI, H. PEREIRA, S. MANZO-SILBERMAN, S. ORDONEZ, A. A. ÖZKAN, B. SCHELLER, H. LEHTOLA, R. TELES, C. MANTIS, A. YLITALO, J. A. BRUM SILVEIRA, R. ZONI, I. BESSONOV, S. SAVONITTO, G. KOCHIADAKIS, D. ALEXOPOULOS, C. URIBE, J. KANAKAKIS, B. FAURIE, G. GABRIELLI, A. GUTIÉRREZ, J. P. BACHINI, A. ROCHA, F. C. TAM, A. RODRIGUEZ, A. LUKITO, V. SAINT-JOY, G. PESSAH, B. TUCCILLO, G. CORTESE, G. PARODI, M. A. BOURAGHDA, E. KEDHI, P. LAMELAS, H. SURYAPRANATA, M. NARDIN and M. VERDOIA

Edition

Heart, London, BMJ Publishing Group, 2022, 1355-6037

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30201 Cardiac and Cardiovascular systems

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 5.700

RIV identification code

RIV/00216224:14110/22:00125199

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1136/heartjnl-2021-319750

UT WoS

000724310100001

Keywords in English

COVID-19; mechanical reperfusion; ST elevation myocardial infarction

Tags

14110211, rivok

Tags

International impact, Reviewed
Změněno: 20/7/2022 09:05, Mgr. Tereza Miškechová

Abstract

V originále

Objective The initial data of the International Study on Acute Coronary Syndromes - ST Elevation Myocardial Infarction COVID-19 showed in Europe a remarkable reduction in primary percutaneous coronary intervention procedures and higher in-hospital mortality during the initial phase of the pandemic as compared with the prepandemic period. The aim of the current study was to provide the final results of the registry, subsequently extended outside Europe with a larger inclusion period (up to June 2020) and longer follow-up (up to 30 days). Methods This is a retrospective multicentre registry in 109 high-volume primary percutaneous coronary intervention (PPCI) centres from Europe, Latin America, South-East Asia and North Africa, enrolling 16 674 patients with ST segment elevation myocardial infarction (STEMI) undergoing PPPCI in March/June 2019 and 2020. The main study outcomes were the incidence of PPCI, delayed treatment (ischaemia time >12 hours and door-to-balloon >30 min), in-hospital and 30-day mortality. Results In 2020, during the pandemic there was a significant reduction in PPCI as compared with 2019 (incidence rate ratio 0.843, 95% CI 0.825 to 0.861, p<0.0001). This reduction was significantly associated with age, being higher in older adults (>75 years) (p=0.015), and was not related to the peak of cases or deaths due to COVID-19. The heterogeneity among centres was high (p<0.001). Furthermore, the pandemic was associated with a significant increase in doorto-balloon time (40 (25-70) min vs 40 (25-64) min, p=0.01) and total ischaemia time (225 (135-410) min vs 196 (120-355) min, p<0.001), which may have contributed to the higher in-hospital (6.5% vs 5.3%, p<0.001) and 30-day (8% vs 6.5%, p=0.001) mortality observed during the pandemic. Conclusion Percutaneous revascularisation for STEMI was significantly affected by the COVID-19 pandemic, with a 16% reduction in PPCI procedures, especially among older patients (about 20%), and longer delays to treatment, which may have contributed to the increased in-hospital and 30-day mortality during the pandemic.
Displayed: 5/11/2024 05:26