DE LUCA, G., M. ALGOWHARY, B. UGUZ, D. C. OLIVEIRA, V. GANYUKOV, Z. ZIMBAKOV, M. CERCEK, L. O. JENSEN, P.H . LOH, L. CALMAC, G. ROURA-FERRER, A. QUADROS, M. MILEWSKI, F. SCOTTO DI UCCIO, C. VON BIRGELEN, F. VERSACI, J. TEN BERG, G. CASELLA, A. S. L. WONG, Petr KALA, J. L. DIEZ GIL, X. CARRILLO, M. T. DIRKSEN, VM. BECERRA-MUÑOZ, M. KANG-YIN LEE, D. A. JUZAR, R. DE MOURA JOAQUIM, R. PALADINO, D. MILICIC, P. DAVLOUROS, N. BAKRACESKI, F. ZILIO, L. DONAZZAN, A. O. KRAAIJEVELD, G. GALASSO, A. LUX, L. MARINUCCI, V. GUIDUCCI, M. MENICHELLI, A. SCOCCIA, A. YAMAC, K. UGUR MERT, X. FLORES RIOS, T. KOVARNIK, M. KIDAWA, J. MOREU, V. FLAVIEN, E. FABRIS, I. LOZANO MARTÌNEZ-LUENGAS, M. BOCCALATTE, F. BOSA OJEDA, C. ARELLANO-SERRANO, G. CAIAZZO, G. CIRRINCIONE, H. L. KAO, J. SANCHIS FORES, L. VIGNALI, H. PEREIRA, S. MANZO-SILBERMAN, S. ORDONEZ, A. A. ÖZKAN, B. SCHELLER, H. LEHTOLA, R. TELES, C. MANTIS, A. YLITALO, J. A. BRUM SILVEIRA, R. ZONI, I. BESSONOV, S. SAVONITTO, G. KOCHIADAKIS, D. ALEXOPOULOS, C. URIBE, J. KANAKAKIS, B. FAURIE, G. GABRIELLI, A. GUTIÉRREZ, J. P. BACHINI, A. ROCHA, F. C. TAM, A. RODRIGUEZ, A. LUKITO, V. SAINT-JOY, G. PESSAH, B. TUCCILLO, G. CORTESE, G. PARODI, M. A. BOURAGHDA, E. KEDHI, P. LAMELAS, H. SURYAPRANATA, M. NARDIN and M. VERDOIA. COVID-19 pandemic, mechanical reperfusion and 30-day mortality in ST elevation myocardial infarction. Heart. London: BMJ Publishing Group, 2022, vol. 108, No 6, p. 458-466. ISSN 1355-6037. Available from: https://dx.doi.org/10.1136/heartjnl-2021-319750.
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Basic information
Original name COVID-19 pandemic, mechanical reperfusion and 30-day mortality in ST elevation myocardial infarction
Authors DE LUCA, G. (guarantor), M. ALGOWHARY, B. UGUZ, D. C. OLIVEIRA, V. GANYUKOV, Z. ZIMBAKOV, M. CERCEK, L. O. JENSEN, P.H . LOH, L. CALMAC, G. ROURA-FERRER, A. QUADROS, M. MILEWSKI, F. SCOTTO DI UCCIO, C. VON BIRGELEN, F. VERSACI, J. TEN BERG, G. CASELLA, A. S. L. WONG, Petr KALA (203 Czech Republic, belonging to the institution), J. L. DIEZ GIL, X. CARRILLO, M. T. DIRKSEN, VM. BECERRA-MUÑOZ, M. KANG-YIN LEE, D. A. JUZAR, R. DE MOURA JOAQUIM, R. PALADINO, D. MILICIC, P. DAVLOUROS, N. BAKRACESKI, F. ZILIO, L. DONAZZAN, A. O. KRAAIJEVELD, G. GALASSO, A. LUX, L. MARINUCCI, V. GUIDUCCI, M. MENICHELLI, A. SCOCCIA, A. YAMAC, K. UGUR MERT, X. FLORES RIOS, T. KOVARNIK, M. KIDAWA, J. MOREU, V. FLAVIEN, E. FABRIS, I. LOZANO MARTÌNEZ-LUENGAS, M. BOCCALATTE, F. BOSA OJEDA, C. ARELLANO-SERRANO, G. CAIAZZO, G. CIRRINCIONE, H. L. KAO, J. SANCHIS FORES, L. VIGNALI, H. PEREIRA, S. MANZO-SILBERMAN, S. ORDONEZ, A. A. ÖZKAN, B. SCHELLER, H. LEHTOLA, R. TELES, C. MANTIS, A. YLITALO, J. A. BRUM SILVEIRA, R. ZONI, I. BESSONOV, S. SAVONITTO, G. KOCHIADAKIS, D. ALEXOPOULOS, C. URIBE, J. KANAKAKIS, B. FAURIE, G. GABRIELLI, A. GUTIÉRREZ, J. P. BACHINI, A. ROCHA, F. C. TAM, A. RODRIGUEZ, A. LUKITO, V. SAINT-JOY, G. PESSAH, B. TUCCILLO, G. CORTESE, G. PARODI, M. A. BOURAGHDA, E. KEDHI, P. LAMELAS, H. SURYAPRANATA, M. NARDIN and M. VERDOIA.
Edition Heart, London, BMJ Publishing Group, 2022, 1355-6037.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30201 Cardiac and Cardiovascular systems
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 5.700
RIV identification code RIV/00216224:14110/22:00125199
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1136/heartjnl-2021-319750
UT WoS 000724310100001
Keywords in English COVID-19; mechanical reperfusion; ST elevation myocardial infarction
Tags 14110211, rivok
Tags International impact, Reviewed
Changed by Changed by: Mgr. Tereza Miškechová, učo 341652. Changed: 20/7/2022 09:05.
Abstract
Objective The initial data of the International Study on Acute Coronary Syndromes - ST Elevation Myocardial Infarction COVID-19 showed in Europe a remarkable reduction in primary percutaneous coronary intervention procedures and higher in-hospital mortality during the initial phase of the pandemic as compared with the prepandemic period. The aim of the current study was to provide the final results of the registry, subsequently extended outside Europe with a larger inclusion period (up to June 2020) and longer follow-up (up to 30 days). Methods This is a retrospective multicentre registry in 109 high-volume primary percutaneous coronary intervention (PPCI) centres from Europe, Latin America, South-East Asia and North Africa, enrolling 16 674 patients with ST segment elevation myocardial infarction (STEMI) undergoing PPPCI in March/June 2019 and 2020. The main study outcomes were the incidence of PPCI, delayed treatment (ischaemia time >12 hours and door-to-balloon >30 min), in-hospital and 30-day mortality. Results In 2020, during the pandemic there was a significant reduction in PPCI as compared with 2019 (incidence rate ratio 0.843, 95% CI 0.825 to 0.861, p<0.0001). This reduction was significantly associated with age, being higher in older adults (>75 years) (p=0.015), and was not related to the peak of cases or deaths due to COVID-19. The heterogeneity among centres was high (p<0.001). Furthermore, the pandemic was associated with a significant increase in doorto-balloon time (40 (25-70) min vs 40 (25-64) min, p=0.01) and total ischaemia time (225 (135-410) min vs 196 (120-355) min, p<0.001), which may have contributed to the higher in-hospital (6.5% vs 5.3%, p<0.001) and 30-day (8% vs 6.5%, p=0.001) mortality observed during the pandemic. Conclusion Percutaneous revascularisation for STEMI was significantly affected by the COVID-19 pandemic, with a 16% reduction in PPCI procedures, especially among older patients (about 20%), and longer delays to treatment, which may have contributed to the increased in-hospital and 30-day mortality during the pandemic.
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