COVID-19 pandemic, mechanical reperfusion and 30-day mortality
in ST elevation myocardial infarction

J 2022

COVID-19 pandemic, mechanical reperfusion and 30-day mortality in ST elevation myocardial infarction

DE LUCA, G., M. ALGOWHARY, B. UGUZ, D. C. OLIVEIRA, V. GANYUKOV et. al.

Basic information

Original name

COVID-19 pandemic, mechanical reperfusion and 30-day mortality in ST elevation myocardial infarction

Authors

DE LUCA, G. (guarantor), M. ALGOWHARY, B. UGUZ, D. C. OLIVEIRA, V. GANYUKOV, Z. ZIMBAKOV, M. CERCEK, L. O. JENSEN, P.H . LOH, L. CALMAC, G. ROURA-FERRER, A. QUADROS, M. MILEWSKI, F. SCOTTO DI UCCIO, C. VON BIRGELEN, F. VERSACI, J. TEN BERG, G. CASELLA, A. S. L. WONG, Petr KALA (203 Czech Republic, belonging to the institution), J. L. DIEZ GIL, X. CARRILLO, M. T. DIRKSEN, VM. BECERRA-MUÑOZ, M. KANG-YIN LEE, D. A. JUZAR, R. DE MOURA JOAQUIM, R. PALADINO, D. MILICIC, P. DAVLOUROS, N. BAKRACESKI, F. ZILIO, L. DONAZZAN, A. O. KRAAIJEVELD, G. GALASSO, A. LUX, L. MARINUCCI, V. GUIDUCCI, M. MENICHELLI, A. SCOCCIA, A. YAMAC, K. UGUR MERT, X. FLORES RIOS, T. KOVARNIK, M. KIDAWA, J. MOREU, V. FLAVIEN, E. FABRIS, I. LOZANO MARTÌNEZ-LUENGAS, M. BOCCALATTE, F. BOSA OJEDA, C. ARELLANO-SERRANO, G. CAIAZZO, G. CIRRINCIONE, H. L. KAO, J. SANCHIS FORES, L. VIGNALI, H. PEREIRA, S. MANZO-SILBERMAN, S. ORDONEZ, A. A. ÖZKAN, B. SCHELLER, H. LEHTOLA, R. TELES, C. MANTIS, A. YLITALO, J. A. BRUM SILVEIRA, R. ZONI, I. BESSONOV, S. SAVONITTO, G. KOCHIADAKIS, D. ALEXOPOULOS, C. URIBE, J. KANAKAKIS, B. FAURIE, G. GABRIELLI, A. GUTIÉRREZ, J. P. BACHINI, A. ROCHA, F. C. TAM, A. RODRIGUEZ, A. LUKITO, V. SAINT-JOY, G. PESSAH, B. TUCCILLO, G. CORTESE, G. PARODI, M. A. BOURAGHDA, E. KEDHI, P. LAMELAS, H. SURYAPRANATA, M. NARDIN and M. VERDOIA

Edition

Heart, London, BMJ Publishing Group, 2022, 1355-6037

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30201 Cardiac and Cardiovascular systems

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 5.700

RIV identification code

RIV/00216224:14110/22:00125199

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1136/heartjnl-2021-319750

UT WoS

000724310100001

Keywords in English

COVID-19; mechanical reperfusion; ST elevation myocardial infarction

Abstract

V originále

Objective The initial data of the International Study on Acute Coronary Syndromes - ST Elevation Myocardial Infarction COVID-19 showed in Europe a remarkable reduction in primary percutaneous coronary intervention procedures and higher in-hospital mortality during the initial phase of the pandemic as compared with the prepandemic period. The aim of the current study was to provide the final results of the registry, subsequently extended outside Europe with a larger inclusion period (up to June 2020) and longer follow-up (up to 30 days). Methods This is a retrospective multicentre registry in 109 high-volume primary percutaneous coronary intervention (PPCI) centres from Europe, Latin America, South-East Asia and North Africa, enrolling 16 674 patients with ST segment elevation myocardial infarction (STEMI) undergoing PPPCI in March/June 2019 and 2020. The main study outcomes were the incidence of PPCI, delayed treatment (ischaemia time >12 hours and door-to-balloon >30 min), in-hospital and 30-day mortality. Results In 2020, during the pandemic there was a significant reduction in PPCI as compared with 2019 (incidence rate ratio 0.843, 95% CI 0.825 to 0.861, p<0.0001). This reduction was significantly associated with age, being higher in older adults (>75 years) (p=0.015), and was not related to the peak of cases or deaths due to COVID-19. The heterogeneity among centres was high (p<0.001). Furthermore, the pandemic was associated with a significant increase in doorto-balloon time (40 (25-70) min vs 40 (25-64) min, p=0.01) and total ischaemia time (225 (135-410) min vs 196 (120-355) min, p<0.001), which may have contributed to the higher in-hospital (6.5% vs 5.3%, p<0.001) and 30-day (8% vs 6.5%, p=0.001) mortality observed during the pandemic. Conclusion Percutaneous revascularisation for STEMI was significantly affected by the COVID-19 pandemic, with a 16% reduction in PPCI procedures, especially among older patients (about 20%), and longer delays to treatment, which may have contributed to the increased in-hospital and 30-day mortality during the pandemic.

Citovat

DE LUCA, G., M. ALGOWHARY, B. UGUZ, D. C. OLIVEIRA, V. GANYUKOV, Z. ZIMBAKOV, M. CERCEK, L. O. JENSEN, P.H . LOH, L. CALMAC, G. ROURA-FERRER, A. QUADROS, M. MILEWSKI, F. SCOTTO DI UCCIO, C. VON BIRGELEN, F. VERSACI, J. TEN BERG, G. CASELLA, A. S. L. WONG, Petr KALA, J. L. DIEZ GIL, X. CARRILLO, M. T. DIRKSEN, VM. BECERRA-MUÑOZ, M. KANG-YIN LEE, D. A. JUZAR, R. DE MOURA JOAQUIM, R. PALADINO, D. MILICIC, P. DAVLOUROS, N. BAKRACESKI, F. ZILIO, L. DONAZZAN, A. O. KRAAIJEVELD, G. GALASSO, A. LUX, L. MARINUCCI, V. GUIDUCCI, M. MENICHELLI, A. SCOCCIA, A. YAMAC, K. UGUR MERT, X. FLORES RIOS, T. KOVARNIK, M. KIDAWA, J. MOREU, V. FLAVIEN, E. FABRIS, I. LOZANO MARTÌNEZ-LUENGAS, M. BOCCALATTE, F. BOSA OJEDA, C. ARELLANO-SERRANO, G. CAIAZZO, G. CIRRINCIONE, H. L. KAO, J. SANCHIS FORES, L. VIGNALI, H. PEREIRA, S. MANZO-SILBERMAN, S. ORDONEZ, A. A. ÖZKAN, B. SCHELLER, H. LEHTOLA, R. TELES, C. MANTIS, A. YLITALO, J. A. BRUM SILVEIRA, R. ZONI, I. BESSONOV, S. SAVONITTO, G. KOCHIADAKIS, D. ALEXOPOULOS, C. URIBE, J. KANAKAKIS, B. FAURIE, G. GABRIELLI, A. GUTIÉRREZ, J. P. BACHINI, A. ROCHA, F. C. TAM, A. RODRIGUEZ, A. LUKITO, V. SAINT-JOY, G. PESSAH, B. TUCCILLO, G. CORTESE, G. PARODI, M. A. BOURAGHDA, E. KEDHI, P. LAMELAS, H. SURYAPRANATA, M. NARDIN and M. VERDOIA. COVID-19 pandemic, mechanical reperfusion and 30-day mortality in ST elevation myocardial infarction. Heart. London: BMJ Publishing Group, 2022, vol. 108, No 6, p. 458-466. ISSN 1355-6037. Available from: https://dx.doi.org/10.1136/heartjnl-2021-319750.

@article{1823998,
   author = {De Luca, G. and Algowhary, M. and Uguz, B. and Oliveira, D. C. and Ganyukov, V. and Zimbakov, Z. and Cercek, M. and Jensen, L. O. and Loh, P.H . and Calmac, L. and RouraandFerrer, G. and Quadros, A. and Milewski, M. and Scotto di Uccio, F. and von Birgelen, C. and Versaci, F. and Ten Berg, J. and Casella, G. and Wong, A. S. L. and Kala, Petr and Diez Gil, J. L. and Carrillo, X. and Dirksen, M. T. and BecerraandMuñoz, VM. and KangandYin Lee, M. and Juzar, D. A. and de Moura Joaquim, R. and Paladino, R. and Milicic, D. and Davlouros, P. and Bakraceski, N. and Zilio, F. and Donazzan, L. and Kraaijeveld, A. O. and Galasso, G. and Lux, A. and Marinucci, L. and Guiducci, V. and Menichelli, M. and Scoccia, A. and Yamac, A. and Ugur Mert, K. and Flores Rios, X. and Kovarnik, T. and Kidawa, M. and Moreu, J. and Flavien, V. and Fabris, E. and Lozano MartìnezandLuengas, I. and Boccalatte, M. and Bosa Ojeda, F. and ArellanoandSerrano, C. and Caiazzo, G. and Cirrincione, G. and Kao, H. L. and Sanchis Fores, J. and Vignali, L. and Pereira, H. and ManzoandSilberman, S. and Ordonez, S. and Özkan, A. A. and Scheller, B. and Lehtola, H. and Teles, R. and Mantis, C. and Ylitalo, A. and Brum Silveira, J. A. and Zoni, R. and Bessonov, I. and Savonitto, S. and Kochiadakis, G. and Alexopoulos, D. and Uribe, C. and Kanakakis, J. and Faurie, B. and Gabrielli, G. and Gutiérrez, A. and Bachini, J. P. and Rocha, A. and Tam, F. C. and Rodriguez, A. and Lukito, A. and SaintandJoy, V. and Pessah, G. and Tuccillo, B. and Cortese, G. and Parodi, G. and Bouraghda, M. A. and Kedhi, E. and Lamelas, P. and Suryapranata, H. and Nardin, M. and Verdoia, M.},
   article_location = {London},
   article_number = {6},
   doi = {http://dx.doi.org/10.1136/heartjnl-2021-319750},
   keywords = {COVID-19; mechanical reperfusion; ST elevation myocardial infarction},
   language = {eng},
   issn = {1355-6037},
   journal = {Heart},
   title = {COVID-19 pandemic, mechanical reperfusion and 30-day mortality in ST elevation myocardial infarction},
   url = {https://heart.bmj.com/content/early/2021/10/27/heartjnl-2021-319750},
   volume = {108},
   year = {2022}
}

TY  - JOUR
ID  - 1823998
AU  - De Luca, G. - Algowhary, M. - Uguz, B. - Oliveira, D. C. - Ganyukov, V. - Zimbakov, Z. - Cercek, M. - Jensen, L. O. - Loh, P.H . - Calmac, L. - Roura-Ferrer, G. - Quadros, A. - Milewski, M. - Scotto di Uccio, F. - von Birgelen, C. - Versaci, F. - Ten Berg, J. - Casella, G. - Wong, A. S. L. - Kala, Petr - Diez Gil, J. L. - Carrillo, X. - Dirksen, M. T. - Becerra-Muñoz, VM. - Kang-Yin Lee, M. - Juzar, D. A. - de Moura Joaquim, R. - Paladino, R. - Milicic, D. - Davlouros, P. - Bakraceski, N. - Zilio, F. - Donazzan, L. - Kraaijeveld, A. O. - Galasso, G. - Lux, A. - Marinucci, L. - Guiducci, V. - Menichelli, M. - Scoccia, A. - Yamac, A. - Ugur Mert, K. - Flores Rios, X. - Kovarnik, T. - Kidawa, M. - Moreu, J. - Flavien, V. - Fabris, E. - Lozano Martìnez-Luengas, I. - Boccalatte, M. - Bosa Ojeda, F. - Arellano-Serrano, C. - Caiazzo, G. - Cirrincione, G. - Kao, H. L. - Sanchis Fores, J. - Vignali, L. - Pereira, H. - Manzo-Silberman, S. - Ordonez, S. - Özkan, A. A. - Scheller, B. - Lehtola, H. - Teles, R. - Mantis, C. - Ylitalo, A. - Brum Silveira, J. A. - Zoni, R. - Bessonov, I. - Savonitto, S. - Kochiadakis, G. - Alexopoulos, D. - Uribe, C. - Kanakakis, J. - Faurie, B. - Gabrielli, G. - Gutiérrez, A. - Bachini, J. P. - Rocha, A. - Tam, F. C. - Rodriguez, A. - Lukito, A. - Saint-Joy, V. - Pessah, G. - Tuccillo, B. - Cortese, G. - Parodi, G. - Bouraghda, M. A. - Kedhi, E. - Lamelas, P. - Suryapranata, H. - Nardin, M. - Verdoia, M.
PY  - 2022
TI  - COVID-19 pandemic, mechanical reperfusion and 30-day mortality in ST elevation myocardial infarction
JF  - Heart
VL  - 108
IS  - 6
SP  - 458-466
EP  - 458-466
PB  - BMJ Publishing Group
SN  - 13556037
KW  - COVID-19
KW  - mechanical reperfusion
KW  - ST elevation myocardial infarction
UR  - https://heart.bmj.com/content/early/2021/10/27/heartjnl-2021-319750
N2  - Objective The initial data of the International Study on Acute Coronary Syndromes - ST Elevation Myocardial Infarction COVID-19 showed in Europe a remarkable reduction in primary percutaneous coronary intervention procedures and higher in-hospital mortality during the initial phase of the pandemic as compared with the prepandemic period. The aim of the current study was to provide the final results of the registry, subsequently extended outside Europe with a larger inclusion period (up to June 2020) and longer follow-up (up to 30 days). Methods This is a retrospective multicentre registry in 109 high-volume primary percutaneous coronary intervention (PPCI) centres from Europe, Latin America, South-East Asia and North Africa, enrolling 16 674 patients with ST segment elevation myocardial infarction (STEMI) undergoing PPPCI in March/June 2019 and 2020. The main study outcomes were the incidence of PPCI, delayed treatment (ischaemia time >12 hours and door-to-balloon >30 min), in-hospital and 30-day mortality. Results In 2020, during the pandemic there was a significant reduction in PPCI as compared with 2019 (incidence rate ratio 0.843, 95% CI 0.825 to 0.861, p<0.0001). This reduction was significantly associated with age, being higher in older adults (>75 years) (p=0.015), and was not related to the peak of cases or deaths due to COVID-19. The heterogeneity among centres was high (p<0.001). Furthermore, the pandemic was associated with a significant increase in doorto-balloon time (40 (25-70) min vs 40 (25-64) min, p=0.01) and total ischaemia time (225 (135-410) min vs 196 (120-355) min, p<0.001), which may have contributed to the higher in-hospital (6.5% vs 5.3%, p<0.001) and 30-day (8% vs 6.5%, p=0.001) mortality observed during the pandemic. Conclusion Percutaneous revascularisation for STEMI was significantly affected by the COVID-19 pandemic, with a 16% reduction in PPCI procedures, especially among older patients (about 20%), and longer delays to treatment, which may have contributed to the increased in-hospital and 30-day mortality during the pandemic.
ER  -

DE LUCA, G., M. ALGOWHARY, B. UGUZ, D. C. OLIVEIRA, V. GANYUKOV, Z. ZIMBAKOV, M. CERCEK, L. O. JENSEN, P.H . LOH, L. CALMAC, G. ROURA-FERRER, A. QUADROS, M. MILEWSKI, F. SCOTTO DI UCCIO, C. VON BIRGELEN, F. VERSACI, J. TEN BERG, G. CASELLA, A. S. L. WONG, Petr KALA, J. L. DIEZ GIL, X. CARRILLO, M. T. DIRKSEN, VM. BECERRA-MUÑOZ, M. KANG-YIN LEE, D. A. JUZAR, R. DE MOURA JOAQUIM, R. PALADINO, D. MILICIC, P. DAVLOUROS, N. BAKRACESKI, F. ZILIO, L. DONAZZAN, A. O. KRAAIJEVELD, G. GALASSO, A. LUX, L. MARINUCCI, V. GUIDUCCI, M. MENICHELLI, A. SCOCCIA, A. YAMAC, K. UGUR MERT, X. FLORES RIOS, T. KOVARNIK, M. KIDAWA, J. MOREU, V. FLAVIEN, E. FABRIS, I. LOZANO MARTÌNEZ-LUENGAS, M. BOCCALATTE, F. BOSA OJEDA, C. ARELLANO-SERRANO, G. CAIAZZO, G. CIRRINCIONE, H. L. KAO, J. SANCHIS FORES, L. VIGNALI, H. PEREIRA, S. MANZO-SILBERMAN, S. ORDONEZ, A. A. ÖZKAN, B. SCHELLER, H. LEHTOLA, R. TELES, C. MANTIS, A. YLITALO, J. A. BRUM SILVEIRA, R. ZONI, I. BESSONOV, S. SAVONITTO, G. KOCHIADAKIS, D. ALEXOPOULOS, C. URIBE, J. KANAKAKIS, B. FAURIE, G. GABRIELLI, A. GUTIÉRREZ, J. P. BACHINI, A. ROCHA, F. C. TAM, A. RODRIGUEZ, A. LUKITO, V. SAINT-JOY, G. PESSAH, B. TUCCILLO, G. CORTESE, G. PARODI, M. A. BOURAGHDA, E. KEDHI, P. LAMELAS, H. SURYAPRANATA, M. NARDIN and M. VERDOIA. COVID-19 pandemic, mechanical reperfusion and 30-day mortality in ST elevation myocardial infarction. \textit{Heart}. London: BMJ Publishing Group, 2022, vol.~108, No~6, p.~458-466. ISSN~1355-6037. Available from: https://dx.doi.org/10.1136/heartjnl-2021-319750.

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