SALEK, Cyril, František FOLBER, Eva FRONKOVA, Pavla PECHERKOVA, Hana JELINKOVA, Štěpán HRABOVSKÝ, Jan M. HORACEK, Petr CETKOVSKY, Jiří MAYER, Jan TRKA and Michael DOUBEK. Low levels of minimal residual disease after induction chemotherapy for BCR-ABL1-negative acute lymphoblastic leukaemia in adults are clinically relevant. British journal of haematology. England: Wiley-Blackwell, 2022, vol. 196, No 3, p. 706-710. ISSN 0007-1048. Available from: https://dx.doi.org/10.1111/bjh.17966. |
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@article{1824604, author = {Salek, Cyril and Folber, František and Fronkova, Eva and Pecherkova, Pavla and Jelinkova, Hana and Hrabovský, Štěpán and Horacek, Jan M. and Cetkovsky, Petr and Mayer, Jiří and Trka, Jan and Doubek, Michael}, article_location = {England}, article_number = {3}, doi = {http://dx.doi.org/10.1111/bjh.17966}, keywords = {acute lymphoblastic leukaemia; minimal residual disease; prognostic factors; PCR; IG; TR rearrangements}, language = {eng}, issn = {0007-1048}, journal = {British journal of haematology}, title = {Low levels of minimal residual disease after induction chemotherapy for BCR-ABL1-negative acute lymphoblastic leukaemia in adults are clinically relevant}, url = {https://onlinelibrary.wiley.com/doi/10.1111/bjh.17966}, volume = {196}, year = {2022} }
TY - JOUR ID - 1824604 AU - Salek, Cyril - Folber, František - Fronkova, Eva - Pecherkova, Pavla - Jelinkova, Hana - Hrabovský, Štěpán - Horacek, Jan M. - Cetkovsky, Petr - Mayer, Jiří - Trka, Jan - Doubek, Michael PY - 2022 TI - Low levels of minimal residual disease after induction chemotherapy for BCR-ABL1-negative acute lymphoblastic leukaemia in adults are clinically relevant JF - British journal of haematology VL - 196 IS - 3 SP - 706-710 EP - 706-710 PB - Wiley-Blackwell SN - 00071048 KW - acute lymphoblastic leukaemia KW - minimal residual disease KW - prognostic factors KW - PCR KW - IG KW - TR rearrangements UR - https://onlinelibrary.wiley.com/doi/10.1111/bjh.17966 N2 - The aim of the present study was to evaluate the significance of low-level minimal/measurable residual disease (MRD) during early consolidation treatment in adult BCR-ABL1-negative acute lymphoblastic leukaemia. The MRD load was monitored by immunoglobulin/T-cell receptor rearrangements and assessed as negative [complete MRD response (CMR)], positive non-quantifiable (MRDnq) and positive quantifiable (MRDq). MRDnq before the first and second consolidation blocks had a comparable negative effect on survival as MRDq. The 5-year overall survival for CMR, MRDnq and MRDq at week 11 was 74 center dot 0%, 42 center dot 3% and 35 center dot 0% respectively. No central nervous system infiltration and MRD at week 11 were independent prognostic factors for survival on multivariate analysis (hazard ratios 0 center dot 32 and 2 center dot 25). ER -
SALEK, Cyril, František FOLBER, Eva FRONKOVA, Pavla PECHERKOVA, Hana JELINKOVA, Štěpán HRABOVSKÝ, Jan M. HORACEK, Petr CETKOVSKY, Jiří MAYER, Jan TRKA and Michael DOUBEK. Low levels of minimal residual disease after induction chemotherapy for BCR-ABL1-negative acute lymphoblastic leukaemia in adults are clinically relevant. \textit{British journal of haematology}. England: Wiley-Blackwell, 2022, vol.~196, No~3, p.~706-710. ISSN~0007-1048. Available from: https://dx.doi.org/10.1111/bjh.17966.
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