Low levels of minimal residual disease after induction
chemotherapy for BCR-ABL1-negative acute lymphoblastic
leukaemia in adults are clinically relevant

J 2022

Low levels of minimal residual disease after induction chemotherapy for BCR-ABL1-negative acute lymphoblastic leukaemia in adults are clinically relevant

SALEK, Cyril, František FOLBER, Eva FRONKOVA, Pavla PECHERKOVA, Hana JELINKOVA et. al.

Basic information

Original name

Low levels of minimal residual disease after induction chemotherapy for BCR-ABL1-negative acute lymphoblastic leukaemia in adults are clinically relevant

Authors

SALEK, Cyril (203 Czech Republic, guarantor), František FOLBER (203 Czech Republic, belonging to the institution), Eva FRONKOVA (203 Czech Republic), Pavla PECHERKOVA (203 Czech Republic), Hana JELINKOVA (203 Czech Republic), Štěpán HRABOVSKÝ (203 Czech Republic, belonging to the institution), Jan M. HORACEK (203 Czech Republic), Petr CETKOVSKY (203 Czech Republic), Jiří MAYER (203 Czech Republic, belonging to the institution), Jan TRKA (203 Czech Republic) and Michael DOUBEK (203 Czech Republic, belonging to the institution)

Edition

British journal of haematology, England, Wiley-Blackwell, 2022, 0007-1048

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30205 Hematology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 6.500

RIV identification code

RIV/00216224:14110/22:00125210

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1111/bjh.17966

UT WoS

000728535400001

Keywords in English

acute lymphoblastic leukaemia; minimal residual disease; prognostic factors; PCR; IG; TR rearrangements

Abstract

V originále

The aim of the present study was to evaluate the significance of low-level minimal/measurable residual disease (MRD) during early consolidation treatment in adult BCR-ABL1-negative acute lymphoblastic leukaemia. The MRD load was monitored by immunoglobulin/T-cell receptor rearrangements and assessed as negative [complete MRD response (CMR)], positive non-quantifiable (MRDnq) and positive quantifiable (MRDq). MRDnq before the first and second consolidation blocks had a comparable negative effect on survival as MRDq. The 5-year overall survival for CMR, MRDnq and MRDq at week 11 was 74 center dot 0%, 42 center dot 3% and 35 center dot 0% respectively. No central nervous system infiltration and MRD at week 11 were independent prognostic factors for survival on multivariate analysis (hazard ratios 0 center dot 32 and 2 center dot 25).

Citovat

SALEK, Cyril, František FOLBER, Eva FRONKOVA, Pavla PECHERKOVA, Hana JELINKOVA, Štěpán HRABOVSKÝ, Jan M. HORACEK, Petr CETKOVSKY, Jiří MAYER, Jan TRKA and Michael DOUBEK. Low levels of minimal residual disease after induction chemotherapy for BCR-ABL1-negative acute lymphoblastic leukaemia in adults are clinically relevant. British journal of haematology. England: Wiley-Blackwell, 2022, vol. 196, No 3, p. 706-710. ISSN 0007-1048. Available from: https://dx.doi.org/10.1111/bjh.17966.

@article{1824604,
   author = {Salek, Cyril and Folber, František and Fronkova, Eva and Pecherkova, Pavla and Jelinkova, Hana and Hrabovský, Štěpán and Horacek, Jan M. and Cetkovsky, Petr and Mayer, Jiří and Trka, Jan and Doubek, Michael},
   article_location = {England},
   article_number = {3},
   doi = {http://dx.doi.org/10.1111/bjh.17966},
   keywords = {acute lymphoblastic leukaemia; minimal residual disease; prognostic factors; PCR; IG; TR rearrangements},
   language = {eng},
   issn = {0007-1048},
   journal = {British journal of haematology},
   title = {Low levels of minimal residual disease after induction chemotherapy for BCR-ABL1-negative acute lymphoblastic leukaemia in adults are clinically relevant},
   url = {https://onlinelibrary.wiley.com/doi/10.1111/bjh.17966},
   volume = {196},
   year = {2022}
}

TY  - JOUR
ID  - 1824604
AU  - Salek, Cyril - Folber, František - Fronkova, Eva - Pecherkova, Pavla - Jelinkova, Hana - Hrabovský, Štěpán - Horacek, Jan M. - Cetkovsky, Petr - Mayer, Jiří - Trka, Jan - Doubek, Michael
PY  - 2022
TI  - Low levels of minimal residual disease after induction chemotherapy for BCR-ABL1-negative acute lymphoblastic leukaemia in adults are clinically relevant
JF  - British journal of haematology
VL  - 196
IS  - 3
SP  - 706-710
EP  - 706-710
PB  - Wiley-Blackwell
SN  - 00071048
KW  - acute lymphoblastic leukaemia
KW  - minimal residual disease
KW  - prognostic factors
KW  - PCR
KW  - IG
KW  - TR rearrangements
UR  - https://onlinelibrary.wiley.com/doi/10.1111/bjh.17966
N2  - The aim of the present study was to evaluate the significance of low-level minimal/measurable residual disease (MRD) during early consolidation treatment in adult BCR-ABL1-negative acute lymphoblastic leukaemia. The MRD load was monitored by immunoglobulin/T-cell receptor rearrangements and assessed as negative [complete MRD response (CMR)], positive non-quantifiable (MRDnq) and positive quantifiable (MRDq). MRDnq before the first and second consolidation blocks had a comparable negative effect on survival as MRDq. The 5-year overall survival for CMR, MRDnq and MRDq at week 11 was 74 center dot 0%, 42 center dot 3% and 35 center dot 0% respectively. No central nervous system infiltration and MRD at week 11 were independent prognostic factors for survival on multivariate analysis (hazard ratios 0 center dot 32 and 2 center dot 25).
ER  -

SALEK, Cyril, František FOLBER, Eva FRONKOVA, Pavla PECHERKOVA, Hana JELINKOVA, Štěpán HRABOVSKÝ, Jan M. HORACEK, Petr CETKOVSKY, Jiří MAYER, Jan TRKA and Michael DOUBEK. Low levels of minimal residual disease after induction chemotherapy for BCR-ABL1-negative acute lymphoblastic leukaemia in adults are clinically relevant. \textit{British journal of haematology}. England: Wiley-Blackwell, 2022, vol.~196, No~3, p.~706-710. ISSN~0007-1048. Available from: https://dx.doi.org/10.1111/bjh.17966.

Detailed Information on Publication Record