Risk factors for depression and anxiety in painful and painless
diabetic polyneuropathy: A multicentre observational
cross-sectional study

J 2022

Risk factors for depression and anxiety in painful and painless diabetic polyneuropathy: A multicentre observational cross-sectional study

KEC, David, Aneta RAJDOVÁ, Jana RAPUTOVÁ, Blanka ADAMOVÁ, Iva ŠROTOVÁ et. al.

Basic information

Original name

Risk factors for depression and anxiety in painful and painless diabetic polyneuropathy: A multicentre observational cross-sectional study

Authors

KEC, David (203 Czech Republic, belonging to the institution), Aneta RAJDOVÁ (203 Czech Republic, belonging to the institution), Jana RAPUTOVÁ (203 Czech Republic, belonging to the institution), Blanka ADAMOVÁ (203 Czech Republic, belonging to the institution), Iva ŠROTOVÁ (203 Czech Republic, belonging to the institution), Eva KRÁLÍČKOVÁ NEKVAPILOVÁ (203 Czech Republic, belonging to the institution), Radka NEUŽILOVÁ MICHALČÁKOVÁ (203 Czech Republic), Magda HORÁKOVÁ (203 Czech Republic, belonging to the institution), Jana BELOBRADKOVA (203 Czech Republic), Jindrich OLSOVSKY (203 Czech Republic), Pavel WEBER (203 Czech Republic), Gabriel HAJAS (703 Slovakia), Michaela KAISEROVA (203 Czech Republic), Radim MAZANEC (203 Czech Republic), Veronika POTOCKOVA (203 Czech Republic), Edvard EHLER (203 Czech Republic), Martin FORGAC (203 Czech Republic), Frank BIRKLEIN, Nurcan UCEYLER, Claudia SOMMER, Josef BEDNAŘÍK (203 Czech Republic, belonging to the institution) and Eva VLČKOVÁ (203 Czech Republic, guarantor, belonging to the institution)

Edition

European Journal of Pain, Hoboken, Wiley, 2022, 1090-3801

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30210 Clinical neurology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.600

RIV identification code

RIV/00216224:14110/22:00125211

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1002/ejp.1865

UT WoS

000705522100001

Keywords in English

depression; anxiety; diabetic polyneuropathy; risk factors

Abstract

V originále

Background Despite the high prevalence of depression and anxiety in chronic pain conditions, current knowledge concerning emotional distress among painful diabetic polyneuropathy (pDSPN) and other diabetes mellitus (DM) sufferers is limited. Methods This observational multicentre cohort study employed the Hospital Anxiety and Depression Scale, the Beck Depression Inventory II and the State-Trait Anxiety Inventory to assess symptoms of depression and anxiety in several groups with diabetes, as well as in a control group. The study cohort included 347 pDSPN patients aged 63.4 years (median), 55.9% males; 311 pain-free diabetic polyneuropathy (nDSPN) patients aged 63.7 years, 57.9% males; 50 diabetes mellitus (DM) patients without polyneuropathy aged 61.5 years, 44.0% males; and 71 healthy controls (HC) aged 63.0 years, 42.3% males. The roles played in emotional distress were explored in terms of the biological, the clinical (diabetes-, neuropathy- and pain-related), the socio-economic and the cognitive factors (catastrophizing). Results The study disclosed a significantly higher prevalence of the symptoms of depression and anxiety not only in pDSPN (46.7% and 60.7%, respectively), but also in patients with nDSPN (24.4% and 44.4%) and DM without polyneuropathy (22.0% and 30.0%) compared with HCs (7.0% and 14.1%, p < 0.001). Multiple regression analysis demonstrated the severity of pain and neuropathy, catastrophic thinking, type 2 DM, lower age and female sex as independent contributors to depression and anxiety. Conclusions In addition to the severity of neuropathic pain and its cognitive processing, the severity of diabetic polyneuropathy and demographic factors are key independent contributors to emotional distress in diabetic individuals. Significance In large cohorts of well-defined painless and painful diabetic polyneuropathy patients and diabetic subjects without polyneuropathy, we found a high prevalence of the symptoms of depression and anxiety, mainly in painful individuals. We have confirmed neuropathic pain, its severity and cognitive processing (pain catastrophizing) as dominant risk factors for depression and anxiety. Furthermore, some demographic factors (lower age, female sex), type 2 diabetes mellitus and severity of diabetic polyneuropathy were newly identified as important contributors to emotional distress independent of pain.

Links

ED1.1.00/02.0068, research and development project

Name: CEITEC - central european institute of technology

MUNI/A/1144/2021, interní kód MU

Name: Diagnostika a patofyziologie neuropatické bolesti a dalších symptomů a komorbidit neurologických onemocnění

Investor: Masaryk University

MUNI/A/1600/2020, interní kód MU

Name: Diagnostika a patofyziologie neuropatické bolesti (Acronym: PNB)

Investor: Masaryk University

602133, interní kód MU

Name: ncRNAPain - Non-coding RNAs in neurogenic and neuropathic pain mechanisms and their application for risk assessment, patient stratification and personalised pain medicine (Acronym: ncRNAPain)

Investor: European Union, Cooperation

Citovat

KEC, David, Aneta RAJDOVÁ, Jana RAPUTOVÁ, Blanka ADAMOVÁ, Iva ŠROTOVÁ, Eva KRÁLÍČKOVÁ NEKVAPILOVÁ, Radka NEUŽILOVÁ MICHALČÁKOVÁ, Magda HORÁKOVÁ, Jana BELOBRADKOVA, Jindrich OLSOVSKY, Pavel WEBER, Gabriel HAJAS, Michaela KAISEROVA, Radim MAZANEC, Veronika POTOCKOVA, Edvard EHLER, Martin FORGAC, Frank BIRKLEIN, Nurcan UCEYLER, Claudia SOMMER, Josef BEDNAŘÍK and Eva VLČKOVÁ. Risk factors for depression and anxiety in painful and painless diabetic polyneuropathy: A multicentre observational cross-sectional study. European Journal of Pain. Hoboken: Wiley, 2022, vol. 26, No 2, p. 370-389. ISSN 1090-3801. Available from: https://dx.doi.org/10.1002/ejp.1865.

@article{1824610,
   author = {Kec, David and Rajdová, Aneta and Raputová, Jana and Adamová, Blanka and Šrotová, Iva and Králíčková Nekvapilová, Eva and Neužilová Michalčáková, Radka and Horáková, Magda and Belobradkova, Jana and Olsovsky, Jindrich and Weber, Pavel and Hajas, Gabriel and Kaiserova, Michaela and Mazanec, Radim and Potockova, Veronika and Ehler, Edvard and Forgac, Martin and Birklein, Frank and Uceyler, Nurcan and Sommer, Claudia and Bednařík, Josef and Vlčková, Eva},
   article_location = {Hoboken},
   article_number = {2},
   doi = {http://dx.doi.org/10.1002/ejp.1865},
   keywords = {depression; anxiety; diabetic polyneuropathy; risk factors},
   language = {eng},
   issn = {1090-3801},
   journal = {European Journal of Pain},
   title = {Risk factors for depression and anxiety in painful and painless diabetic polyneuropathy: A multicentre observational cross-sectional study},
   url = {https://onlinelibrary.wiley.com/doi/epdf/10.1002/ejp.1865},
   volume = {26},
   year = {2022}
}

TY  - JOUR
ID  - 1824610
AU  - Kec, David - Rajdová, Aneta - Raputová, Jana - Adamová, Blanka - Šrotová, Iva - Králíčková Nekvapilová, Eva - Neužilová Michalčáková, Radka - Horáková, Magda - Belobradkova, Jana - Olsovsky, Jindrich - Weber, Pavel - Hajas, Gabriel - Kaiserova, Michaela - Mazanec, Radim - Potockova, Veronika - Ehler, Edvard - Forgac, Martin - Birklein, Frank - Uceyler, Nurcan - Sommer, Claudia - Bednařík, Josef - Vlčková, Eva
PY  - 2022
TI  - Risk factors for depression and anxiety in painful and painless diabetic polyneuropathy: A multicentre observational cross-sectional study
JF  - European Journal of Pain
VL  - 26
IS  - 2
SP  - 370-389
EP  - 370-389
PB  - Wiley
SN  - 10903801
KW  - depression
KW  - anxiety
KW  - diabetic polyneuropathy
KW  - risk factors
UR  - https://onlinelibrary.wiley.com/doi/epdf/10.1002/ejp.1865
N2  - Background Despite the high prevalence of depression and anxiety in chronic pain conditions, current knowledge concerning emotional distress among painful diabetic polyneuropathy (pDSPN) and other diabetes mellitus (DM) sufferers is limited. Methods This observational multicentre cohort study employed the Hospital Anxiety and Depression Scale, the Beck Depression Inventory II and the State-Trait Anxiety Inventory to assess symptoms of depression and anxiety in several groups with diabetes, as well as in a control group. The study cohort included 347 pDSPN patients aged 63.4 years (median), 55.9% males; 311 pain-free diabetic polyneuropathy (nDSPN) patients aged 63.7 years, 57.9% males; 50 diabetes mellitus (DM) patients without polyneuropathy aged 61.5 years, 44.0% males; and 71 healthy controls (HC) aged 63.0 years, 42.3% males. The roles played in emotional distress were explored in terms of the biological, the clinical (diabetes-, neuropathy- and pain-related), the socio-economic and the cognitive factors (catastrophizing). Results The study disclosed a significantly higher prevalence of the symptoms of depression and anxiety not only in pDSPN (46.7% and 60.7%, respectively), but also in patients with nDSPN (24.4% and 44.4%) and DM without polyneuropathy (22.0% and 30.0%) compared with HCs (7.0% and 14.1%, p < 0.001). Multiple regression analysis demonstrated the severity of pain and neuropathy, catastrophic thinking, type 2 DM, lower age and female sex as independent contributors to depression and anxiety. Conclusions In addition to the severity of neuropathic pain and its cognitive processing, the severity of diabetic polyneuropathy and demographic factors are key independent contributors to emotional distress in diabetic individuals. Significance In large cohorts of well-defined painless and painful diabetic polyneuropathy patients and diabetic subjects without polyneuropathy, we found a high prevalence of the symptoms of depression and anxiety, mainly in painful individuals. We have confirmed neuropathic pain, its severity and cognitive processing (pain catastrophizing) as dominant risk factors for depression and anxiety. Furthermore, some demographic factors (lower age, female sex), type 2 diabetes mellitus and severity of diabetic polyneuropathy were newly identified as important contributors to emotional distress independent of pain.
ER  -

KEC, David, Aneta RAJDOVÁ, Jana RAPUTOVÁ, Blanka ADAMOVÁ, Iva ŠROTOVÁ, Eva KRÁLÍČKOVÁ NEKVAPILOVÁ, Radka NEUŽILOVÁ MICHALČÁKOVÁ, Magda HORÁKOVÁ, Jana BELOBRADKOVA, Jindrich OLSOVSKY, Pavel WEBER, Gabriel HAJAS, Michaela KAISEROVA, Radim MAZANEC, Veronika POTOCKOVA, Edvard EHLER, Martin FORGAC, Frank BIRKLEIN, Nurcan UCEYLER, Claudia SOMMER, Josef BEDNAŘÍK and Eva VLČKOVÁ. Risk factors for depression and anxiety in painful and painless diabetic polyneuropathy: A multicentre observational cross-sectional study. \textit{European Journal of Pain}. Hoboken: Wiley, 2022, vol.~26, No~2, p.~370-389. ISSN~1090-3801. Available from: https://dx.doi.org/10.1002/ejp.1865.

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