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@article{1824697,
author = {Bora, Pablo and Gahurová, Lenka and Mašek, Tomáš and Hauserová, Andrea and Potěšil, David and Jansová, Denisa and Susor, Andrej and Zdráhal, Zbyněk and Ajduk, Anna and Pospíšek, Martin and Bruce, Alexander W.},
article_number = {1},
doi = {http://dx.doi.org/10.1038/s42003-021-02290-z},
keywords = {ACTIVATED PROTEIN-KINASE; INNER CELL MASS; MAP KINASE; PREIMPLANTATION EMBRYO; MESSENGER-RNA; NA/K-ATPASE; 1A MYBBP1A; P38 MAPK; MOUSE; GROWTH},
language = {eng},
issn = {2399-3642},
journal = {Communications Biology},
title = {p38-MAPK-mediated translation regulation during early blastocyst development is required for primitive endoderm differentiation in mice},
url = {https://www.nature.com/articles/s42003-021-02290-z.pdf},
volume = {4},
year = {2021}
}
TY - JOUR
ID - 1824697
AU - Bora, Pablo - Gahurová, Lenka - Mašek, Tomáš - Hauserová, Andrea - Potěšil, David - Jansová, Denisa - Susor, Andrej - Zdráhal, Zbyněk - Ajduk, Anna - Pospíšek, Martin - Bruce, Alexander W.
PY - 2021
TI - p38-MAPK-mediated translation regulation during early blastocyst development is required for primitive endoderm differentiation in mice
JF - Communications Biology
VL - 4
IS - 1
SP - "788"
EP - "788"
SN - 23993642
KW - ACTIVATED PROTEIN-KINASE
KW - INNER CELL MASS
KW - MAP KINASE
KW - PREIMPLANTATION EMBRYO
KW - MESSENGER-RNA
KW - NA/K-ATPASE
KW - 1A MYBBP1A
KW - P38 MAPK
KW - MOUSE
KW - GROWTH
UR - https://www.nature.com/articles/s42003-021-02290-z.pdf
N2 - Successful specification of the two mouse blastocyst inner cell mass (ICM) lineages (the primitive endoderm (PrE) and epiblast) is a prerequisite for continued development and requires active fibroblast growth factor 4 (FGF4) signaling. Previously, we identified a role for p38 mitogen-activated protein kinases (p38-MAPKs) during PrE differentiation, but the underlying mechanisms have remained unresolved. Here, we report an early blastocyst window of p38-MAPK activity that is required to regulate ribosome-related gene expression, rRNA precursor processing, polysome formation and protein translation. We show that p38-MAPK inhibition-induced PrE phenotypes can be partially rescued by activating the translational regulator mTOR. However, similar PrE phenotypes associated with extracellular signal-regulated kinase (ERK) pathway inhibition targeting active FGF4 signaling are not affected by mTOR activation. These data indicate a specific role for p38-MAPKs in providing a permissive translational environment during mouse blastocyst PrE differentiation that is distinct from classically reported FGF4-based mechanisms. Bora et al. show that an early blastocyst window of p38-MAPK activity regulates ribosome-related gene expression, rRNA precursor processing, polysome formation, and protein translation. This study suggests a distinct role of p38-MAPKs for providing a permissive translational environment during mouse blastocyst primitive endoderm differentiation.
ER -
BORA, Pablo, Lenka GAHUROVÁ, Tomáš MAŠEK, Andrea HAUSEROVÁ, David POTĚŠIL, Denisa JANSOVÁ, Andrej SUSOR, Zbyněk ZDRÁHAL, Anna AJDUK, Martin POSPÍŠEK and Alexander W. BRUCE. p38-MAPK-mediated translation regulation during early blastocyst development is required for primitive endoderm differentiation in mice. \textit{Communications Biology}. 2021, vol.~4, No~1, p.~''788'', 19 pp. ISSN~2399-3642. Available from: https://dx.doi.org/10.1038/s42003-021-02290-z.
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