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@article{1824697, author = {Bora, Pablo and Gahurová, Lenka and Mašek, Tomáš and Hauserová, Andrea and Potěšil, David and Jansová, Denisa and Susor, Andrej and Zdráhal, Zbyněk and Ajduk, Anna and Pospíšek, Martin and Bruce, Alexander W.}, article_number = {1}, doi = {http://dx.doi.org/10.1038/s42003-021-02290-z}, keywords = {ACTIVATED PROTEIN-KINASE; INNER CELL MASS; MAP KINASE; PREIMPLANTATION EMBRYO; MESSENGER-RNA; NA/K-ATPASE; 1A MYBBP1A; P38 MAPK; MOUSE; GROWTH}, language = {eng}, issn = {2399-3642}, journal = {Communications Biology}, title = {p38-MAPK-mediated translation regulation during early blastocyst development is required for primitive endoderm differentiation in mice}, url = {https://www.nature.com/articles/s42003-021-02290-z.pdf}, volume = {4}, year = {2021} }
TY - JOUR ID - 1824697 AU - Bora, Pablo - Gahurová, Lenka - Mašek, Tomáš - Hauserová, Andrea - Potěšil, David - Jansová, Denisa - Susor, Andrej - Zdráhal, Zbyněk - Ajduk, Anna - Pospíšek, Martin - Bruce, Alexander W. PY - 2021 TI - p38-MAPK-mediated translation regulation during early blastocyst development is required for primitive endoderm differentiation in mice JF - Communications Biology VL - 4 IS - 1 SP - "788" EP - "788" SN - 23993642 KW - ACTIVATED PROTEIN-KINASE KW - INNER CELL MASS KW - MAP KINASE KW - PREIMPLANTATION EMBRYO KW - MESSENGER-RNA KW - NA/K-ATPASE KW - 1A MYBBP1A KW - P38 MAPK KW - MOUSE KW - GROWTH UR - https://www.nature.com/articles/s42003-021-02290-z.pdf N2 - Successful specification of the two mouse blastocyst inner cell mass (ICM) lineages (the primitive endoderm (PrE) and epiblast) is a prerequisite for continued development and requires active fibroblast growth factor 4 (FGF4) signaling. Previously, we identified a role for p38 mitogen-activated protein kinases (p38-MAPKs) during PrE differentiation, but the underlying mechanisms have remained unresolved. Here, we report an early blastocyst window of p38-MAPK activity that is required to regulate ribosome-related gene expression, rRNA precursor processing, polysome formation and protein translation. We show that p38-MAPK inhibition-induced PrE phenotypes can be partially rescued by activating the translational regulator mTOR. However, similar PrE phenotypes associated with extracellular signal-regulated kinase (ERK) pathway inhibition targeting active FGF4 signaling are not affected by mTOR activation. These data indicate a specific role for p38-MAPKs in providing a permissive translational environment during mouse blastocyst PrE differentiation that is distinct from classically reported FGF4-based mechanisms. Bora et al. show that an early blastocyst window of p38-MAPK activity regulates ribosome-related gene expression, rRNA precursor processing, polysome formation, and protein translation. This study suggests a distinct role of p38-MAPKs for providing a permissive translational environment during mouse blastocyst primitive endoderm differentiation. ER -
BORA, Pablo, Lenka GAHUROVÁ, Tomáš MAŠEK, Andrea HAUSEROVÁ, David POTĚŠIL, Denisa JANSOVÁ, Andrej SUSOR, Zbyněk ZDRÁHAL, Anna AJDUK, Martin POSPÍŠEK and Alexander W. BRUCE. p38-MAPK-mediated translation regulation during early blastocyst development is required for primitive endoderm differentiation in mice. \textit{Communications Biology}. 2021, vol.~4, No~1, p.~''788'', 19 pp. ISSN~2399-3642. Available from: https://dx.doi.org/10.1038/s42003-021-02290-z.
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