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@article{1824781,
author = {Šponerová, Judit and Šponer, Jiří and Výravský, Jakub and Šedo, Ondrej and Zdráhal, Zbyněk and Costanzo, Giovanna and di Mauro, Ernesto and Wunnava, Sreekar and Braun, Dieter and Matyášek, Roman and Kovařík, Aleš},
article_number = {6},
doi = {http://dx.doi.org/10.1002/syst.202100017},
keywords = {minerals; nucleotides; oligomerization; oligonucleotides; self-assembly},
language = {eng},
issn = {2570-4206},
journal = {ChemSystemsChem},
title = {Nonenzymatic, Template-Free Polymerization of 3',5' Cyclic Guanosine Monophosphate on Mineral Surfaces},
url = {https://chemistry-europe.onlinelibrary.wiley.com/doi/epdf/10.1002/syst.202100017},
volume = {3},
year = {2021}
}
TY - JOUR
ID - 1824781
AU - Šponerová, Judit - Šponer, Jiří - Výravský, Jakub - Šedo, Ondrej - Zdráhal, Zbyněk - Costanzo, Giovanna - di Mauro, Ernesto - Wunnava, Sreekar - Braun, Dieter - Matyášek, Roman - Kovařík, Aleš
PY - 2021
TI - Nonenzymatic, Template-Free Polymerization of 3',5' Cyclic Guanosine Monophosphate on Mineral Surfaces
JF - ChemSystemsChem
VL - 3
IS - 6
SP - "e2100017"
EP - "e2100017"
PB - Wiley
SN - 25704206
KW - minerals
KW - nucleotides
KW - oligomerization
KW - oligonucleotides
KW - self-assembly
UR - https://chemistry-europe.onlinelibrary.wiley.com/doi/epdf/10.1002/syst.202100017
N2 - Previous studies on the polymerization of 3',5' cyclic guanosine monophosphate (cGMP) demonstrated the potential of the compound in the abiotic generation of the first oligonucleotide sequences on the early Earth. These experiments were conducted under idealized laboratory conditions, which logically raises the question whether the same chemistry could take place in the harsh environment present on our planet in its earliest days. In the current study, we focus on the mineralogical context of this chemistry and show that numerous, but not all, common minerals assumed to be present on the early Earth could host the polymerization of H-form 3',5' cGMP. In particular, we have found that quartz varieties are especially suitable for this purpose, similar to andalusite, amphibole or micas. On the contrary, olivine, calcite, and serpentine-group minerals interfere with the studied polymerization chemistry. Our results show that crystallization on mineral surfaces, which is mainly a diffusion controlled process, determines the ability of 3',5' cGMP to polymerize. The observation that numerous amorphous and crystalline SiO2 forms are compatible with the oligomerization chemistry suggests that the process could commonly occur in a wide range of primordial environments allowing for crystallization of the cyclic monomers from a dropping solution.
ER -
ŠPONEROVÁ, Judit, Jiří ŠPONER, Jakub VÝRAVSKÝ, Ondrej ŠEDO, Zbyněk ZDRÁHAL, Giovanna COSTANZO, Ernesto DI MAURO, Sreekar WUNNAVA, Dieter BRAUN, Roman MATYÁŠEK and Aleš KOVAŘÍK. Nonenzymatic, Template-Free Polymerization of 3',5' Cyclic Guanosine Monophosphate on Mineral Surfaces. \textit{ChemSystemsChem}. Wiley, 2021, vol.~3, No~6, p.~''e2100017'', 8 pp. ISSN~2570-4206. Available from: https://dx.doi.org/10.1002/syst.202100017.
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