Nonenzymatic, Template-Free Polymerization of 3',5' Cyclic
Guanosine Monophosphate on Mineral Surfaces

J 2021

Nonenzymatic, Template-Free Polymerization of 3',5' Cyclic Guanosine Monophosphate on Mineral Surfaces

ŠPONEROVÁ, Judit, Jiří ŠPONER, Jakub VÝRAVSKÝ, Ondrej ŠEDO, Zbyněk ZDRÁHAL et. al.

Basic information

Original name

Nonenzymatic, Template-Free Polymerization of 3',5' Cyclic Guanosine Monophosphate on Mineral Surfaces

Authors

ŠPONEROVÁ, Judit (348 Hungary), Jiří ŠPONER (203 Czech Republic), Jakub VÝRAVSKÝ (203 Czech Republic, belonging to the institution), Ondrej ŠEDO (203 Czech Republic, belonging to the institution), Zbyněk ZDRÁHAL (203 Czech Republic, guarantor, belonging to the institution), Giovanna COSTANZO (380 Italy), Ernesto DI MAURO (380 Italy), Sreekar WUNNAVA (276 Germany), Dieter BRAUN (276 Germany), Roman MATYÁŠEK (203 Czech Republic) and Aleš KOVAŘÍK (203 Czech Republic)

Edition

ChemSystemsChem, Wiley, 2021, 2570-4206

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10400 1.4 Chemical sciences

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

fulltext

RIV identification code

RIV/00216224:14310/21:00119600

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.1002/syst.202100017

UT WoS

000671941700001

Keywords in English

minerals; nucleotides; oligomerization; oligonucleotides; self-assembly

Abstract

V originále

Previous studies on the polymerization of 3',5' cyclic guanosine monophosphate (cGMP) demonstrated the potential of the compound in the abiotic generation of the first oligonucleotide sequences on the early Earth. These experiments were conducted under idealized laboratory conditions, which logically raises the question whether the same chemistry could take place in the harsh environment present on our planet in its earliest days. In the current study, we focus on the mineralogical context of this chemistry and show that numerous, but not all, common minerals assumed to be present on the early Earth could host the polymerization of H-form 3',5' cGMP. In particular, we have found that quartz varieties are especially suitable for this purpose, similar to andalusite, amphibole or micas. On the contrary, olivine, calcite, and serpentine-group minerals interfere with the studied polymerization chemistry. Our results show that crystallization on mineral surfaces, which is mainly a diffusion controlled process, determines the ability of 3',5' cGMP to polymerize. The observation that numerous amorphous and crystalline SiO2 forms are compatible with the oligomerization chemistry suggests that the process could commonly occur in a wide range of primordial environments allowing for crystallization of the cyclic monomers from a dropping solution.

Links

GA19-03442S, research and development project

Name: Geny pro ribozomální RNA - cestovatelé v čase a genomech

Investor: Czech Science Foundation, Ribosomal RNA genes - travellers in time and the genomes

90127, large research infrastructures

Name: CIISB II

Citovat

ŠPONEROVÁ, Judit, Jiří ŠPONER, Jakub VÝRAVSKÝ, Ondrej ŠEDO, Zbyněk ZDRÁHAL, Giovanna COSTANZO, Ernesto DI MAURO, Sreekar WUNNAVA, Dieter BRAUN, Roman MATYÁŠEK and Aleš KOVAŘÍK. Nonenzymatic, Template-Free Polymerization of 3',5' Cyclic Guanosine Monophosphate on Mineral Surfaces. ChemSystemsChem. Wiley, 2021, vol. 3, No 6, p. "e2100017", 8 pp. ISSN 2570-4206. Available from: https://dx.doi.org/10.1002/syst.202100017.

@article{1824781,
   author = {Šponerová, Judit and Šponer, Jiří and Výravský, Jakub and Šedo, Ondrej and Zdráhal, Zbyněk and Costanzo, Giovanna and di Mauro, Ernesto and Wunnava, Sreekar and Braun, Dieter and Matyášek, Roman and Kovařík, Aleš},
   article_number = {6},
   doi = {http://dx.doi.org/10.1002/syst.202100017},
   keywords = {minerals; nucleotides; oligomerization; oligonucleotides; self-assembly},
   language = {eng},
   issn = {2570-4206},
   journal = {ChemSystemsChem},
   title = {Nonenzymatic, Template-Free Polymerization of 3',5' Cyclic Guanosine Monophosphate on Mineral Surfaces},
   url = {https://chemistry-europe.onlinelibrary.wiley.com/doi/epdf/10.1002/syst.202100017},
   volume = {3},
   year = {2021}
}

TY  - JOUR
ID  - 1824781
AU  - Šponerová, Judit - Šponer, Jiří - Výravský, Jakub - Šedo, Ondrej - Zdráhal, Zbyněk - Costanzo, Giovanna - di Mauro, Ernesto - Wunnava, Sreekar - Braun, Dieter - Matyášek, Roman - Kovařík, Aleš
PY  - 2021
TI  - Nonenzymatic, Template-Free Polymerization of 3',5' Cyclic Guanosine Monophosphate on Mineral Surfaces
JF  - ChemSystemsChem
VL  - 3
IS  - 6
SP  - "e2100017"
EP  - "e2100017"
PB  - Wiley
SN  - 25704206
KW  - minerals
KW  - nucleotides
KW  - oligomerization
KW  - oligonucleotides
KW  - self-assembly
UR  - https://chemistry-europe.onlinelibrary.wiley.com/doi/epdf/10.1002/syst.202100017
N2  - Previous studies on the polymerization of 3',5' cyclic guanosine monophosphate (cGMP) demonstrated the potential of the compound in the abiotic generation of the first oligonucleotide sequences on the early Earth. These experiments were conducted under idealized laboratory conditions, which logically raises the question whether the same chemistry could take place in the harsh environment present on our planet in its earliest days. In the current study, we focus on the mineralogical context of this chemistry and show that numerous, but not all, common minerals assumed to be present on the early Earth could host the polymerization of H-form 3',5' cGMP. In particular, we have found that quartz varieties are especially suitable for this purpose, similar to andalusite, amphibole or micas. On the contrary, olivine, calcite, and serpentine-group minerals interfere with the studied polymerization chemistry. Our results show that crystallization on mineral surfaces, which is mainly a diffusion controlled process, determines the ability of 3',5' cGMP to polymerize. The observation that numerous amorphous and crystalline SiO2 forms are compatible with the oligomerization chemistry suggests that the process could commonly occur in a wide range of primordial environments allowing for crystallization of the cyclic monomers from a dropping solution.
ER  -

ŠPONEROVÁ, Judit, Jiří ŠPONER, Jakub VÝRAVSKÝ, Ondrej ŠEDO, Zbyněk ZDRÁHAL, Giovanna COSTANZO, Ernesto DI MAURO, Sreekar WUNNAVA, Dieter BRAUN, Roman MATYÁŠEK and Aleš KOVAŘÍK. Nonenzymatic, Template-Free Polymerization of 3',5' Cyclic Guanosine Monophosphate on Mineral Surfaces. \textit{ChemSystemsChem}. Wiley, 2021, vol.~3, No~6, p.~''e2100017'', 8 pp. ISSN~2570-4206. Available from: https://dx.doi.org/10.1002/syst.202100017.

Detailed Information on Publication Record