A systematic review on the use of quantitative imaging to
detect cancer therapy adverse effects in normal-appearing brain
tissue

J 2022

A systematic review on the use of quantitative imaging to detect cancer therapy adverse effects in normal-appearing brain tissue

PETR, J., L. HOGEBOOM, P. NIKULIN, E. WIEGERS, G. SCHROYEN et. al.

Basic information

Original name

A systematic review on the use of quantitative imaging to detect cancer therapy adverse effects in normal-appearing brain tissue

Authors

PETR, J. (276 Germany, guarantor), L. HOGEBOOM (528 Netherlands), P. NIKULIN (276 Germany), E. WIEGERS (528 Netherlands), G. SCHROYEN (56 Belgium), J. KALLEHAUGE (208 Denmark), M. CHMELIK (703 Slovakia), P. CLEMENT (56 Belgium), R. E. NECHIFOR (642 Romania), L. A. FODOR (642 Romania), P. C. D. HAMER (528 Netherlands), F. BARKHOF (528 Netherlands), C. PERNET (208 Denmark), M. LEQUIN (528 Netherlands), S. DEPREZ (56 Belgium), Radim JANČÁLEK (203 Czech Republic, belonging to the institution), H. J. M. M. MUTSAERTS (528 Netherlands), F. B. PIZZINI (380 Italy), K. E. EMBLEM (578 Norway) and V. C. KEIL (528 Netherlands)

Edition

MAGMA Magnetic Resonance Materials in Physics, Biology and Medicine, NEW YORK, Springer-Verlag GmbH, 2022, 1352-8661

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30103 Neurosciences

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 2.300

RIV identification code

RIV/00216224:14110/22:00125243

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1007/s10334-021-00985-2

UT WoS

000731201900001

Keywords in English

Neuroimaging; Radiotherapy; Chemotherapy; Long-term adverse effects; Cognitive decline

Abstract

V originále

Cancer therapy for both central nervous system (CNS) and non-CNS tumors has been previously associated with transient and long-term cognitive deterioration, commonly referred to as 'chemo fog'. This therapy-related damage to otherwise normal-appearing brain tissue is reported using post-mortem neuropathological analysis. Although the literature on monitoring therapy effects on structural magnetic resonance imaging (MRI) is well established, such macroscopic structural changes appear relatively late and irreversible. Early quantitative MRI biomarkers of therapy-induced damage would potentially permit taking these treatment side effects into account, paving the way towards a more personalized treatment planning. This systematic review (PROSPERO number 224196) provides an overview of quantitative tomographic imaging methods, potentially identifying the adverse side effects of cancer therapy in normal-appearing brain tissue. Seventy studies were obtained from the MEDLINE and Web of Science databases. Studies reporting changes in normal-appearing brain tissue using MRI, PET, or SPECT quantitative biomarkers, related to radio-, chemo-, immuno-, or hormone therapy for any kind of solid, cystic, or liquid tumor were included. The main findings of the reviewed studies were summarized, providing also the risk of bias of each study assessed using a modified QUADAS-2 tool. For each imaging method, this review provides the methodological background, and the benefits and shortcomings of each method from the imaging perspective. Finally, a set of recommendations is proposed to support future research.

Citovat

PETR, J., L. HOGEBOOM, P. NIKULIN, E. WIEGERS, G. SCHROYEN, J. KALLEHAUGE, M. CHMELIK, P. CLEMENT, R. E. NECHIFOR, L. A. FODOR, P. C. D. HAMER, F. BARKHOF, C. PERNET, M. LEQUIN, S. DEPREZ, Radim JANČÁLEK, H. J. M. M. MUTSAERTS, F. B. PIZZINI, K. E. EMBLEM and V. C. KEIL. A systematic review on the use of quantitative imaging to detect cancer therapy adverse effects in normal-appearing brain tissue. MAGMA Magnetic Resonance Materials in Physics, Biology and Medicine. NEW YORK: Springer-Verlag GmbH, 2022, vol. 35, No 1, p. 163-186. ISSN 1352-8661. Available from: https://dx.doi.org/10.1007/s10334-021-00985-2.

@article{1825397,
   author = {Petr, J. and Hogeboom, L. and Nikulin, P. and Wiegers, E. and Schroyen, G. and Kallehauge, J. and Chmelik, M. and Clement, P. and Nechifor, R. E. and Fodor, L. A. and Hamer, P. C. D. and Barkhof, F. and Pernet, C. and Lequin, M. and Deprez, S. and Jančálek, Radim and Mutsaerts, H. J. M. M. and Pizzini, F. B. and Emblem, K. E. and Keil, V. C.},
   article_location = {NEW YORK},
   article_number = {1},
   doi = {http://dx.doi.org/10.1007/s10334-021-00985-2},
   keywords = {Neuroimaging; Radiotherapy; Chemotherapy; Long-term adverse effects; Cognitive decline},
   language = {eng},
   issn = {1352-8661},
   journal = {MAGMA Magnetic Resonance Materials in Physics, Biology and Medicine},
   title = {A systematic review on the use of quantitative imaging to detect cancer therapy adverse effects in normal-appearing brain tissue},
   url = {https://link.springer.com/article/10.1007/s10334-021-00985-2},
   volume = {35},
   year = {2022}
}

TY  - JOUR
ID  - 1825397
AU  - Petr, J. - Hogeboom, L. - Nikulin, P. - Wiegers, E. - Schroyen, G. - Kallehauge, J. - Chmelik, M. - Clement, P. - Nechifor, R. E. - Fodor, L. A. - Hamer, P. C. D. - Barkhof, F. - Pernet, C. - Lequin, M. - Deprez, S. - Jančálek, Radim - Mutsaerts, H. J. M. M. - Pizzini, F. B. - Emblem, K. E. - Keil, V. C.
PY  - 2022
TI  - A systematic review on the use of quantitative imaging to detect cancer therapy adverse effects in normal-appearing brain tissue
JF  - MAGMA Magnetic Resonance Materials in Physics, Biology and Medicine
VL  - 35
IS  - 1
SP  - 163-186
EP  - 163-186
PB  - Springer-Verlag GmbH
SN  - 13528661
KW  - Neuroimaging
KW  - Radiotherapy
KW  - Chemotherapy
KW  - Long-term adverse effects
KW  - Cognitive decline
UR  - https://link.springer.com/article/10.1007/s10334-021-00985-2
N2  - Cancer therapy for both central nervous system (CNS) and non-CNS tumors has been previously associated with transient and long-term cognitive deterioration, commonly referred to as 'chemo fog'. This therapy-related damage to otherwise normal-appearing brain tissue is reported using post-mortem neuropathological analysis. Although the literature on monitoring therapy effects on structural magnetic resonance imaging (MRI) is well established, such macroscopic structural changes appear relatively late and irreversible. Early quantitative MRI biomarkers of therapy-induced damage would potentially permit taking these treatment side effects into account, paving the way towards a more personalized treatment planning. This systematic review (PROSPERO number 224196) provides an overview of quantitative tomographic imaging methods, potentially identifying the adverse side effects of cancer therapy in normal-appearing brain tissue. Seventy studies were obtained from the MEDLINE and Web of Science databases. Studies reporting changes in normal-appearing brain tissue using MRI, PET, or SPECT quantitative biomarkers, related to radio-, chemo-, immuno-, or hormone therapy for any kind of solid, cystic, or liquid tumor were included. The main findings of the reviewed studies were summarized, providing also the risk of bias of each study assessed using a modified QUADAS-2 tool. For each imaging method, this review provides the methodological background, and the benefits and shortcomings of each method from the imaging perspective. Finally, a set of recommendations is proposed to support future research.
ER  -

PETR, J., L. HOGEBOOM, P. NIKULIN, E. WIEGERS, G. SCHROYEN, J. KALLEHAUGE, M. CHMELIK, P. CLEMENT, R. E. NECHIFOR, L. A. FODOR, P. C. D. HAMER, F. BARKHOF, C. PERNET, M. LEQUIN, S. DEPREZ, Radim JANČÁLEK, H. J. M. M. MUTSAERTS, F. B. PIZZINI, K. E. EMBLEM and V. C. KEIL. A systematic review on the use of quantitative imaging to detect cancer therapy adverse effects in normal-appearing brain tissue. \textit{MAGMA Magnetic Resonance Materials in Physics, Biology and Medicine}. NEW YORK: Springer-Verlag GmbH, 2022, vol.~35, No~1, p.~163-186. ISSN~1352-8661. Available from: https://dx.doi.org/10.1007/s10334-021-00985-2.

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