Enhancing cisplatin anticancer effectivity and migrastatic
potential by modulation of molecular weight of oxidized dextran
carrier

J 2021

Enhancing cisplatin anticancer effectivity and migrastatic potential by modulation of molecular weight of oxidized dextran carrier

MUNSTER, L., Michaela FOJTŮ, M. MUCHOVA, F. LATECKA, S. KACEROVA et. al.

Basic information

Original name

Enhancing cisplatin anticancer effectivity and migrastatic potential by modulation of molecular weight of oxidized dextran carrier

Authors

MUNSTER, L., Michaela FOJTŮ (203 Czech Republic, belonging to the institution), M. MUCHOVA (203 Czech Republic), F. LATECKA (203 Czech Republic), S. KACEROVA (203 Czech Republic), Z. CAPAKOVA (203 Czech Republic), Tamara JURIŇÁKOVÁ (703 Slovakia, belonging to the institution), I. KURITKA (203 Czech Republic), Michal MASAŘÍK (203 Czech Republic, belonging to the institution) and J. VICHA (203 Czech Republic, guarantor)

Edition

Carbohydrate Polymers, Oxford, ELSEVIER SCI LTD, 2021, 0144-8617

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10401 Organic chemistry

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 10.723

RIV identification code

RIV/00216224:14110/21:00119604

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.carbpol.2021.118461

UT WoS

000689229600012

Keywords in English

Drug-delivery; Dextran; Periodate oxidation; Molecular weight; Cisplatin; Carrier

Abstract

V originále

The molecular weight (M-w) of dextran derivatives, such as regioselectively oxidized dicarboxydextran (DXA), is greatly influencing their faith in an organism, which could be possibly used to improve anticancer drug delivery. Here we present a modified method of sulfonation-induced chain scission allowing direct and accurate control over the M-w of DXA without increasing its polydispersity. Prepared DXA derivatives (M-w = 10-185 kDa) have been conjugated to cisplatin and the M-w of the carrier found to have a significant impact on cisplatin release rates, in vitro cytotoxicity, and migrastatic potential. Conjugates with the high-M-w DXA showed particularly increased anticancer efficacy. The best conjugate was four times more effective against malignant prostatic cell lines than free cisplatin and significantly inhibited the ovarian cancer cell migration. This was traced to the characteristics of spontaneously formed cisplatin-crosslinked DXA nanogels influenced by M-w of DXA and amount of loaded cisplatin.

Links

GA19-16861S, research and development project

Name: Interakce biomateriálů s kmenovými buňkami v simulovaných in vivo podmínkách (Acronym: IBMSKB)

Investor: Czech Science Foundation

LM2018127, research and development project

Name: Česká infrastruktura pro integrativní strukturní biologii (Acronym: CIISB)

Investor: Ministry of Education, Youth and Sports of the CR

MUNI/A/1246/2020, interní kód MU

Name: Kardiovaskulární systém: od iontového kanálu k celotělovému modelu (Acronym: KAVASYKAMO)

Investor: Masaryk University

MUNI/A/1698/2020, interní kód MU

Name: Od molekulární, buněčné a tkáňové k systémové patofyziologii vybraných komplexních nemocí (Acronym: ComplexPF)

Investor: Masaryk University

MUNI/11/SUP/08/2020, interní kód MU

Name: Pokročilé 3D nádorové sféroidy pro terapeutický in vitro screening

Investor: Masaryk University

Citovat

MUNSTER, L., Michaela FOJTŮ, M. MUCHOVA, F. LATECKA, S. KACEROVA, Z. CAPAKOVA, Tamara JURIŇÁKOVÁ, I. KURITKA, Michal MASAŘÍK and J. VICHA. Enhancing cisplatin anticancer effectivity and migrastatic potential by modulation of molecular weight of oxidized dextran carrier. Carbohydrate Polymers. Oxford: ELSEVIER SCI LTD, 2021, vol. 272, November 2021, p. 1-9. ISSN 0144-8617. Available from: https://dx.doi.org/10.1016/j.carbpol.2021.118461.

@article{1826200,
   author = {Munster, L. and Fojtů, Michaela and Muchova, M. and Latecka, F. and Kacerova, S. and Capakova, Z. and Juriňáková, Tamara and Kuritka, I. and Masařík, Michal and Vicha, J.},
   article_location = {Oxford},
   article_number = {November 2021},
   doi = {http://dx.doi.org/10.1016/j.carbpol.2021.118461},
   keywords = {Drug-delivery; Dextran; Periodate oxidation; Molecular weight; Cisplatin; Carrier},
   language = {eng},
   issn = {0144-8617},
   journal = {Carbohydrate Polymers},
   title = {Enhancing cisplatin anticancer effectivity and migrastatic potential by modulation of molecular weight of oxidized dextran carrier},
   url = {https://reader.elsevier.com/reader/sd/pii/S0144861721008481?token=6B980116FFE89BE9644D630E5871F9E438C2A85EC19DD545C3ABE52B8108EA349F2BD805D3531CE612288A0775CE71A2&originRegion=eu-west-1&originCreation=20220124064804},
   volume = {272},
   year = {2021}
}

TY  - JOUR
ID  - 1826200
AU  - Munster, L. - Fojtů, Michaela - Muchova, M. - Latecka, F. - Kacerova, S. - Capakova, Z. - Juriňáková, Tamara - Kuritka, I. - Masařík, Michal - Vicha, J.
PY  - 2021
TI  - Enhancing cisplatin anticancer effectivity and migrastatic potential by modulation of molecular weight of oxidized dextran carrier
JF  - Carbohydrate Polymers
VL  - 272
IS  - November 2021
SP  - 1-9
EP  - 1-9
PB  - ELSEVIER SCI LTD
SN  - 01448617
KW  - Drug-delivery
KW  - Dextran
KW  - Periodate oxidation
KW  - Molecular weight
KW  - Cisplatin
KW  - Carrier
UR  - https://reader.elsevier.com/reader/sd/pii/S0144861721008481?token=6B980116FFE89BE9644D630E5871F9E438C2A85EC19DD545C3ABE52B8108EA349F2BD805D3531CE612288A0775CE71A2&originRegion=eu-west-1&originCreation=20220124064804
N2  - The molecular weight (M-w) of dextran derivatives, such as regioselectively oxidized dicarboxydextran (DXA), is greatly influencing their faith in an organism, which could be possibly used to improve anticancer drug delivery. Here we present a modified method of sulfonation-induced chain scission allowing direct and accurate control over the M-w of DXA without increasing its polydispersity. Prepared DXA derivatives (M-w = 10-185 kDa) have been conjugated to cisplatin and the M-w of the carrier found to have a significant impact on cisplatin release rates, in vitro cytotoxicity, and migrastatic potential. Conjugates with the high-M-w DXA showed particularly increased anticancer efficacy. The best conjugate was four times more effective against malignant prostatic cell lines than free cisplatin and significantly inhibited the ovarian cancer cell migration. This was traced to the characteristics of spontaneously formed cisplatin-crosslinked DXA nanogels influenced by M-w of DXA and amount of loaded cisplatin.
ER  -

MUNSTER, L., Michaela FOJTŮ, M. MUCHOVA, F. LATECKA, S. KACEROVA, Z. CAPAKOVA, Tamara JURIŇÁKOVÁ, I. KURITKA, Michal MASAŘÍK and J. VICHA. Enhancing cisplatin anticancer effectivity and migrastatic potential by modulation of molecular weight of oxidized dextran carrier. \textit{Carbohydrate Polymers}. Oxford: ELSEVIER SCI LTD, 2021, vol.~272, November 2021, p.~1-9. ISSN~0144-8617. Available from: https://dx.doi.org/10.1016/j.carbpol.2021.118461.

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