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@article{1826217,
author = {Štěpka, Petr and Kratochvílová, Monika and Kuchynka, Michaela and Raudenská, Martina and Holcová Polanská, Hana and Vičar, Tomáš and Vaculovič, Tomáš and Vaculovičová, Markéta and Masařík, Michal},
article_location = {London},
article_number = {October 2021},
doi = {http://dx.doi.org/10.1155/2021/6800294},
keywords = {zinc; copper; iron; platinum; renal distribution; mouse kidney; LA-ICP-MS},
language = {eng},
issn = {2314-6133},
journal = {BioMed Research International},
title = {Determination of Renal Distribution of Zinc, Copper, Iron, and Platinum in Mouse Kidney Using LA-ICP-MS},
url = {https://www.hindawi.com/journals/bmri/2021/6800294/#supplementary-materials},
volume = {2021},
year = {2021}
}
TY - JOUR
ID - 1826217
AU - Štěpka, Petr - Kratochvílová, Monika - Kuchynka, Michaela - Raudenská, Martina - Holcová Polanská, Hana - Vičar, Tomáš - Vaculovič, Tomáš - Vaculovičová, Markéta - Masařík, Michal
PY - 2021
TI - Determination of Renal Distribution of Zinc, Copper, Iron, and Platinum in Mouse Kidney Using LA-ICP-MS
JF - BioMed Research International
VL - 2021
IS - October 2021
SP - 1-8
EP - 1-8
PB - Hindawi
SN - 23146133
KW - zinc
KW - copper
KW - iron
KW - platinum
KW - renal distribution
KW - mouse kidney
KW - LA-ICP-MS
UR - https://www.hindawi.com/journals/bmri/2021/6800294/#supplementary-materials
N2 - The main dose-limiting side effect of cisplatin is nephrotoxicity. The utilization of cisplatin is an issue of balancing tumour toxicity versus platinum-induced nephrotoxicity. In this study, we focused on intraorgan distribution of common essential trace elements zinc, copper, and iron in healthy mouse kidneys and distribution of platinum after cisplatin treatment. Renal distribution in 12 nontreated Nu-Nu mice (males) was assessed by laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS). Furthermore, 9 Nu-Nu mice were treated with cisplatin. The order of elements concentration in kidneys was as follows: Fe > Zn > Cu. All three metals showed the higher concentrations at the cortex and medulla (28.60, 3.35, and 93.83 μg/g for Zn, Cu, and Fe, respectively) and lower concentration at the pelvis and the urinary tract (20.20, 1.93, and 62.48 μg/g for Zn, Cu, and Fe, respectively). No statistically significant difference between cortex and medulla was observed for these elements. After platinum treatment, the concentration of platinum in kidneys was enhanced more than 60-times, . Platinum significantly showed the highest accumulation in cortex (2.11 μg/g) with a gradient distribution. Platinum was less accumulated in medulla and pelvis than in cortex, and the lowest accumulation occurred in the urinary tract (1.13 μg/g). Image processing has been successfully utilized to colocalize metal distribution using LA-ICP-MS and histological samples images.
ER -
ŠTĚPKA, Petr, Monika KRATOCHVÍLOVÁ, Michaela KUCHYNKA, Martina RAUDENSKÁ, Hana HOLCOVÁ POLANSKÁ, Tomáš VIČAR, Tomáš VACULOVIČ, Markéta VACULOVIČOVÁ and Michal MASAŘÍK. Determination of Renal Distribution of Zinc, Copper, Iron, and Platinum in Mouse Kidney Using LA-ICP-MS. \textit{BioMed Research International}. London: Hindawi, 2021, vol.~2021, October 2021, p.~1-8. ISSN~2314-6133. Available from: https://dx.doi.org/10.1155/2021/6800294.
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