BÍLIK, Tomáš, Ivan STUPÁK, Jakub VYSLOUŽIL, Martin ČULEN and Jiří DOHNAL. Prehľad biorelevantných dynamických disolučných prístrojov (An Overview of Biorelevant Dynamic Dissolution Instruments). CHEMICKÉ LISTY. Praha: Česká společnost chemická, 2021, vol. 115, No 11, p. 602-608, 12 pp. ISSN 0009-2770.
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Basic information
Original name Prehľad biorelevantných dynamických disolučných prístrojov
Name (in English) An Overview of Biorelevant Dynamic Dissolution Instruments
Authors BÍLIK, Tomáš (203 Czech Republic, belonging to the institution), Ivan STUPÁK (703 Slovakia, guarantor, belonging to the institution), Jakub VYSLOUŽIL (203 Czech Republic, belonging to the institution), Martin ČULEN (703 Slovakia, belonging to the institution) and Jiří DOHNAL (203 Czech Republic, belonging to the institution).
Edition CHEMICKÉ LISTY, Praha, Česká společnost chemická, 2021, 0009-2770.
Other information
Original language Slovak
Type of outcome Article in a journal
Field of Study 30104 Pharmacology and pharmacy
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 0.356
RIV identification code RIV/00216224:14160/21:00123928
Organization unit Faculty of Pharmacy
UT WoS 000738342100005
Keywords in English solid oral dosage forms; biorelevant dissolution test; in vitro gastrointestinal system
Tags rivok, ÚAF, ÚFT
Tags International impact, Reviewed
Changed by Changed by: JUDr. Sabina Krejčiříková, učo 383857. Changed: 17/2/2022 16:16.
Abstract
The use of solid oral dosage forms depends on the degree of bioavailability of the active pharmaceutical ingredient. The rate and extent of the drug released from the dosage form and subsequently dissolved in the gastrointestinal fluids greatly affects its fate in the human body. In vitro dissolution test may provide an in-depth understanding of a drug formulation's behaviour in vivo, as long as it sufficiently simulates relevant gastrointestinal conditions. Therefore, the development of in vitro gastrointestinal systems, which reflects advanced technology and knowledge about the human body, is receiving considerable attention. This article is focused on the biorelevant dynamic apparatuses and their sophisticated design, overcoming many limitations of conventional dissolution devices and allowing a better correlation with in vivo behaviour of solid oral dosage forms.
Abstract (in English)
The use of solid oral dosage forms depends on the degree of bioavailability of the active pharmaceutical ingredient. The rate and extent of the drug released from the dosage form and subsequently dissolved in the gastrointestinal fluids greatly affects its fate in the human body. In vitro dissolution test may provide an in-depth understanding of a drug formulation's behaviour in vivo, as long as it sufficiently simulates relevant gastrointestinal conditions. Therefore, the development of in vitro gastrointestinal systems, which reflects advanced technology and knowledge about the human body, is receiving considerable attention. This article is focused on the biorelevant dynamic apparatuses and their sophisticated design, overcoming many limitations of conventional dissolution devices and allowing a better correlation with in vivo behaviour of solid oral dosage forms.
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