Detailed Information on Publication Record
2021
Prehľad biorelevantných dynamických disolučných prístrojov
BÍLIK, Tomáš, Ivan STUPÁK, Jakub VYSLOUŽIL, Martin ČULEN, Jiří DOHNAL et. al.Basic information
Original name
Prehľad biorelevantných dynamických disolučných prístrojov
Name (in English)
An Overview of Biorelevant Dynamic Dissolution Instruments
Authors
BÍLIK, Tomáš (203 Czech Republic, belonging to the institution), Ivan STUPÁK (703 Slovakia, guarantor, belonging to the institution), Jakub VYSLOUŽIL (203 Czech Republic, belonging to the institution), Martin ČULEN (703 Slovakia, belonging to the institution) and Jiří DOHNAL (203 Czech Republic, belonging to the institution)
Edition
CHEMICKÉ LISTY, Praha, Česká společnost chemická, 2021, 0009-2770
Other information
Language
Slovak
Type of outcome
Článek v odborném periodiku
Field of Study
30104 Pharmacology and pharmacy
Country of publisher
Czech Republic
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 0.356
RIV identification code
RIV/00216224:14160/21:00123928
Organization unit
Faculty of Pharmacy
UT WoS
000738342100005
Keywords in English
solid oral dosage forms; biorelevant dissolution test; in vitro gastrointestinal system
Tags
International impact, Reviewed
Změněno: 28/8/2024 11:36, Mgr. Michal Petr
V originále
The use of solid oral dosage forms depends on the degree of bioavailability of the active pharmaceutical ingredient. The rate and extent of the drug released from the dosage form and subsequently dissolved in the gastrointestinal fluids greatly affects its fate in the human body. In vitro dissolution test may provide an in-depth understanding of a drug formulation's behaviour in vivo, as long as it sufficiently simulates relevant gastrointestinal conditions. Therefore, the development of in vitro gastrointestinal systems, which reflects advanced technology and knowledge about the human body, is receiving considerable attention. This article is focused on the biorelevant dynamic apparatuses and their sophisticated design, overcoming many limitations of conventional dissolution devices and allowing a better correlation with in vivo behaviour of solid oral dosage forms.
In English
The use of solid oral dosage forms depends on the degree of bioavailability of the active pharmaceutical ingredient. The rate and extent of the drug released from the dosage form and subsequently dissolved in the gastrointestinal fluids greatly affects its fate in the human body. In vitro dissolution test may provide an in-depth understanding of a drug formulation's behaviour in vivo, as long as it sufficiently simulates relevant gastrointestinal conditions. Therefore, the development of in vitro gastrointestinal systems, which reflects advanced technology and knowledge about the human body, is receiving considerable attention. This article is focused on the biorelevant dynamic apparatuses and their sophisticated design, overcoming many limitations of conventional dissolution devices and allowing a better correlation with in vivo behaviour of solid oral dosage forms.