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@article{1826943,
author = {Knowles, J. and Vysloužil, Jakub and Muselík, Jan and Stejskal, V. and Kouril, J. and Podhorec, P.},
article_location = {Prague},
article_number = {8},
doi = {http://dx.doi.org/10.17221/57/2021-CJAS},
keywords = {induction of ovulation; GnRHa; salmonids; sustained drug release; steroid feedback},
language = {eng},
issn = {1212-1819},
journal = {Czech Journal of Animal Science},
title = {Efficacy of poly (lactic-co-glycolic acid) microparticles as a gonadotropin-releasing hormone analogue delivery system to stimulate ovulation of peled Coregonus peled},
url = {https://www.agriculturejournals.cz/web/cjas.htm?type=article&id=57_2021-CJAS},
volume = {66},
year = {2021}
}
TY - JOUR
ID - 1826943
AU - Knowles, J. - Vysloužil, Jakub - Muselík, Jan - Stejskal, V. - Kouril, J. - Podhorec, P.
PY - 2021
TI - Efficacy of poly (lactic-co-glycolic acid) microparticles as a gonadotropin-releasing hormone analogue delivery system to stimulate ovulation of peled Coregonus peled
JF - Czech Journal of Animal Science
VL - 66
IS - 8
SP - 331-338
EP - 331-338
PB - Czech Academy Agricultural Sciences
SN - 12121819
KW - induction of ovulation
KW - GnRHa
KW - salmonids
KW - sustained drug release
KW - steroid feedback
UR - https://www.agriculturejournals.cz/web/cjas.htm?type=article&id=57_2021-CJAS
N2 - The aim of the study was to determine the efficacy of poly (lactic-co-glycolic acid) microparticles as a carrier of gonadotropin-relea sing hormone analogues (GnRHa) for induction of ovulation in peled Coregonus peled. Female peled were injected intraperitoneally with 1) saline solution only (control), 2) mammalian GnRHa at 25 vg/kg body weight, 3) GnRHa in 753-type microparticles at 50 vg/kg, or 4) GnRHa in 653-type microparticles at 50 vg/kg. Blood plasma samples were taken on days 0, 4, 8, and 12 post-injection. All hormone treatments induced synchronous ovulation and higher cumulative ovulation compared to controls. Hormone treatments did not affect relative fecundity or the percentage of eyed eggs. Testosterone level decreased toward the onset of ovulation. On day eight of the trial, the testosterone level was significantly lower in hormone-treated groups compared to the control group. The level of 17P-oestradiol showed a decreasing trend post-injection, with the lowest observed level on day eight. Our results demonstrate that ovulation can be induced in the peled by the sustained - release of GnRHa in poly (lactic-co-glycolic acid) microparticles, but the treatment does not improve reproductive performance.
ER -
KNOWLES, J., Jakub VYSLOUŽIL, Jan MUSELÍK, V. STEJSKAL, J. KOURIL and P. PODHOREC. Efficacy of poly (lactic-co-glycolic acid) microparticles as a gonadotropin-releasing hormone analogue delivery system to stimulate ovulation of peled Coregonus peled. \textit{Czech Journal of Animal Science}. Prague: Czech Academy Agricultural Sciences, 2021, vol.~66, No~8, p.~331-338. ISSN~1212-1819. Available from: https://dx.doi.org/10.17221/57/2021-CJAS.
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