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@article{1827941,
author = {Fohlerová, Zdenka and Kamnev, Kirill and Sepulveda, Marcela and Pytlicek, Zdenek and Prasek, Jan and Mozalev, Alexander},
article_location = {HOBOKEN},
article_number = {14},
doi = {http://dx.doi.org/10.1002/admi.202100256},
keywords = {anodizing; bio-interfaces; biomaterials; nanostructures; porous anodic alumina; Saos-2 cells; ZrO2},
language = {eng},
issn = {2196-7350},
journal = {ADVANCED MATERIALS INTERFACES},
title = {Nanostructured Zirconium-Oxide Bioceramic Coatings Derived from the Anodized Al/Zr Metal Layers},
url = {https://onlinelibrary.wiley.com/doi/10.1002/admi.202100256},
volume = {8},
year = {2021}
}
TY - JOUR
ID - 1827941
AU - Fohlerová, Zdenka - Kamnev, Kirill - Sepulveda, Marcela - Pytlicek, Zdenek - Prasek, Jan - Mozalev, Alexander
PY - 2021
TI - Nanostructured Zirconium-Oxide Bioceramic Coatings Derived from the Anodized Al/Zr Metal Layers
JF - ADVANCED MATERIALS INTERFACES
VL - 8
IS - 14
SP - 1-14
EP - 1-14
PB - WILEY
SN - 21967350
KW - anodizing
KW - bio-interfaces
KW - biomaterials
KW - nanostructures
KW - porous anodic alumina
KW - Saos-2 cells
KW - ZrO2
UR - https://onlinelibrary.wiley.com/doi/10.1002/admi.202100256
N2 - Here, zirconium-oxide ceramic coatings comprising arrays of 3D nanostructures are electrochemically synthesized, ranging in shape, size, spacing, and population density, termed as the nanomounds (empty set approximate to 65 nm), nanopillars (empty set approximate to 130 nm), and nanostumps (empty set approximate to 220 nm). The nanostructured coatings, alongside a flat ZrO2 anodic film, are explored as a potential biomaterial in experiments with Saos-2 cells. All coatings reveal no cytotoxicity to living cells. The population density and spreading area of the cells, being the largest on the flat film, slightly decrease with increasing nanostructure dimensions. The cells progressively proliferate on all the surfaces, the nanomounds and, especially, nanopillars promoting the best viabilities and proliferation rates. The flat, nanomound, and nanopillar coatings promote the well-defined organizations of actin filaments across the entire cell bodies with no disruption in the cytoskeletal network and the mature large dash-shaped focal adhesions. The highest activity of alkaline phosphatase and the biggest deposition of a mineralization-competent extracellular matrix occur on the nanopillar array, the other nanostructures showing a better result than the flat coating, though. The differences, paradoxes, and regularities in the cell responses are explained through the detailed consideration of the coating morphologies, surface chemistries, and processes at the cell/surface interfaces.
ER -
FOHLEROVÁ, Zdenka, Kirill KAMNEV, Marcela SEPULVEDA, Zdenek PYTLICEK, Jan PRASEK and Alexander MOZALEV. Nanostructured Zirconium-Oxide Bioceramic Coatings Derived from the Anodized Al/Zr Metal Layers. \textit{ADVANCED MATERIALS INTERFACES}. HOBOKEN: WILEY, 2021, vol.~8, No~14, p.~1-14. ISSN~2196-7350. Available from: https://dx.doi.org/10.1002/admi.202100256.
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