Pre-implant Heart Activity Differs in Responders and Non-responders to Vagal Nerve Stimulation Therapy in Epileptic Patients

PLESINGER, F., J. HALAMEK, Jan CHLÁDEK, P. JURAK, A. IVORA, Irena DOLEŽALOVÁ, Eva KORIŤÁKOVÁ, Tereza JURKOVÁ, Jan CHRASTINA and Milan BRÁZDIL. Pre-implant Heart Activity Differs in Responders and Non-responders to Vagal Nerve Stimulation Therapy in Epileptic Patients. Online. In 43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society. 30 10 2021. Neuveden: IEEE, 2021, p. 5816-5819. ISSN 2375-7477. Available from: https://dx.doi.org/10.1109/EMBC46164.2021.9629577.

Basic information

• Original name: Pre-implant Heart Activity Differs in Responders and Non-responders to Vagal Nerve Stimulation Therapy in Epileptic Patients
• Authors: PLESINGER, F. (203 Czech Republic), J. HALAMEK (203 Czech Republic), Jan CHLÁDEK (203 Czech Republic, belonging to the institution), P. JURAK (203 Czech Republic), A. IVORA (203 Czech Republic), Irena DOLEŽALOVÁ (203 Czech Republic, belonging to the institution), Eva KORIŤÁKOVÁ (203 Czech Republic, belonging to the institution), Tereza JURKOVÁ (203 Czech Republic, belonging to the institution), Jan CHRASTINA (203 Czech Republic, belonging to the institution) and Milan BRÁZDIL (203 Czech Republic, belonging to the institution).
• Edition: 30 10 2021. Neuveden, 43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, p. 5816-5819, 4 pp. 2021.
• Publisher: IEEE

Other information

• Original language: English
• Type of outcome: Proceedings paper
• Field of Study: 30210 Clinical neurology
• Country of publisher: United States of America
• Confidentiality degree: is not subject to a state or trade secret
• Publication form: electronic version available online
• WWW: URL
• RIV identification code: RIV/00216224:14110/21:00120218
• Organization unit: Faculty of Medicine
• ISSN: 2375-7477
• Doi: http://dx.doi.org/10.1109/EMBC46164.2021.9629577
• UT WoS: 000760910505098
• Keywords in English: Pre-implant Heart Activity; Vagal Nerve Stimulation Therapy; Epileptic Patients
• Tags: rivok
• Tags: International impact, Reviewed

Abstract

Vagal Nerve Stimulation (VNS) is used to treat patients with pharmacoresistant epilepsy. However, generally accepted tools to predict VNS response do not exist. Here we examined two heart activity measures – mean RR and pNN50 and their complex behavior during activation in pre-implant measurements. The ECG recordings of 73 patients (38 responders, 36 non-responders) were examined in a 30-sec floating window before (120 sec), during (2x120 sec), and after (120 sec) the hyperventilation by nose and mouth. The VNS response differentiation by pNN50 was significant (min p=0.01) in the hyperventilation by a nose with a noticeable descendant trend in nominal values. The mean RR was significant (p=0.01) in the rest after the hyperventilation by mouth but after an approximately 40-sec delay.Clinical Relevance— Our study shows that pNN50 and mean RR can be used to distinguish between VNS responders and non-responders. However, details of dynamic behavior showed how this ability varies in tested measurement segments.

Links

• NV19-04-00343, research and development project: Name: Predikce Efektu Stimulace u pacientů s Epilepsií (PRESEnCE) (Acronym: PRESEnCE)

Investor: Ministry of Health of the CR