Pre-implant Heart Activity Differs in Responders and
Non-responders to Vagal Nerve Stimulation Therapy in Epileptic
Patients

D 2021

Pre-implant Heart Activity Differs in Responders and Non-responders to Vagal Nerve Stimulation Therapy in Epileptic Patients

PLESINGER, F., J. HALAMEK, Jan CHLÁDEK, P. JURAK, A. IVORA et. al.

Basic information

Original name

Pre-implant Heart Activity Differs in Responders and Non-responders to Vagal Nerve Stimulation Therapy in Epileptic Patients

Authors

PLESINGER, F. (203 Czech Republic), J. HALAMEK (203 Czech Republic), Jan CHLÁDEK (203 Czech Republic, belonging to the institution), P. JURAK (203 Czech Republic), A. IVORA (203 Czech Republic), Irena DOLEŽALOVÁ (203 Czech Republic, belonging to the institution), Eva KORIŤÁKOVÁ (203 Czech Republic, belonging to the institution), Tereza JURKOVÁ (203 Czech Republic, belonging to the institution), Jan CHRASTINA (203 Czech Republic, belonging to the institution) and Milan BRÁZDIL (203 Czech Republic, belonging to the institution)

Edition

30 10 2021. Neuveden, 43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, p. 5816-5819, 4 pp. 2021

Publisher

IEEE

Other information

Language

English

Type of outcome

Stať ve sborníku

Field of Study

30210 Clinical neurology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Publication form

electronic version available online

References:

URL

RIV identification code

RIV/00216224:14110/21:00120218

Organization unit

Faculty of Medicine

ISSN

DOI

http://dx.doi.org/10.1109/EMBC46164.2021.9629577

UT WoS

000760910505098

Keywords in English

Pre-implant Heart Activity; Vagal Nerve Stimulation Therapy; Epileptic Patients

Abstract

V originále

Vagal Nerve Stimulation (VNS) is used to treat patients with pharmacoresistant epilepsy. However, generally accepted tools to predict VNS response do not exist. Here we examined two heart activity measures – mean RR and pNN50 and their complex behavior during activation in pre-implant measurements. The ECG recordings of 73 patients (38 responders, 36 non-responders) were examined in a 30-sec floating window before (120 sec), during (2x120 sec), and after (120 sec) the hyperventilation by nose and mouth. The VNS response differentiation by pNN50 was significant (min p=0.01) in the hyperventilation by a nose with a noticeable descendant trend in nominal values. The mean RR was significant (p=0.01) in the rest after the hyperventilation by mouth but after an approximately 40-sec delay.Clinical Relevance— Our study shows that pNN50 and mean RR can be used to distinguish between VNS responders and non-responders. However, details of dynamic behavior showed how this ability varies in tested measurement segments.

Links

NV19-04-00343, research and development project

Name: Predikce Efektu Stimulace u pacientů s Epilepsií (PRESEnCE) (Acronym: PRESEnCE)

Investor: Ministry of Health of the CR

Citovat

PLESINGER, F., J. HALAMEK, Jan CHLÁDEK, P. JURAK, A. IVORA, Irena DOLEŽALOVÁ, Eva KORIŤÁKOVÁ, Tereza JURKOVÁ, Jan CHRASTINA and Milan BRÁZDIL. Pre-implant Heart Activity Differs in Responders and Non-responders to Vagal Nerve Stimulation Therapy in Epileptic Patients. Online. In 43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society. 30 10 2021. Neuveden: IEEE, 2021, p. 5816-5819. ISSN 2375-7477. Available from: https://dx.doi.org/10.1109/EMBC46164.2021.9629577.

@inproceedings{1827944,
   author = {Plesinger, F. and Halamek, J. and Chládek, Jan and Jurak, P. and Ivora, A. and Doležalová, Irena and Koriťáková, Eva and Jurková, Tereza and Chrastina, Jan and Brázdil, Milan},
   address = {Neuveden},
   booktitle = {43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society},
   doi = {http://dx.doi.org/10.1109/EMBC46164.2021.9629577},
   edition = {30 10 2021},
   keywords = {Pre-implant Heart Activity; Vagal Nerve Stimulation Therapy; Epileptic Patients},
   howpublished = {elektronická verze "online"},
   language = {eng},
   location = {Neuveden},
   pages = {5816-5819},
   publisher = {IEEE},
   title = {Pre-implant Heart Activity Differs in Responders and Non-responders to Vagal Nerve Stimulation Therapy in Epileptic Patients},
   url = {https://ieeexplore.ieee.org/document/9629577},
   year = {2021}
}

TY  - JOUR
ID  - 1827944
AU  - Plesinger, F. - Halamek, J. - Chládek, Jan - Jurak, P. - Ivora, A. - Doležalová, Irena - Koriťáková, Eva - Jurková, Tereza - Chrastina, Jan - Brázdil, Milan
PY  - 2021
TI  - Pre-implant Heart Activity Differs in Responders and Non-responders to Vagal Nerve Stimulation Therapy in Epileptic Patients
PB  - IEEE
CY  - Neuveden
KW  - Pre-implant Heart Activity
KW  - Vagal Nerve Stimulation Therapy
KW  - Epileptic Patients
UR  - https://ieeexplore.ieee.org/document/9629577
N2  - Vagal Nerve Stimulation (VNS) is used to treat patients with pharmacoresistant epilepsy. However, generally accepted tools to predict VNS response do not exist. Here we examined two heart activity measures – mean RR and pNN50 and their complex behavior during activation in pre-implant measurements. The ECG recordings of 73 patients (38 responders, 36 non-responders) were examined in a 30-sec floating window before (120 sec), during (2x120 sec), and after (120 sec) the hyperventilation by nose and mouth. The VNS response differentiation by pNN50 was significant (min p=0.01) in the hyperventilation by a nose with a noticeable descendant trend in nominal values. The mean RR was significant (p=0.01) in the rest after the hyperventilation by mouth but after an approximately 40-sec delay.Clinical Relevance— Our study shows that pNN50 and mean RR can be used to distinguish between VNS responders and non-responders. However, details of dynamic behavior showed how this ability varies in tested measurement segments.
ER  -

PLESINGER, F., J. HALAMEK, Jan CHLÁDEK, P. JURAK, A. IVORA, Irena DOLEŽALOVÁ, Eva KORIŤÁKOVÁ, Tereza JURKOVÁ, Jan CHRASTINA and Milan BRÁZDIL. Pre-implant Heart Activity Differs in Responders and Non-responders to Vagal Nerve Stimulation Therapy in Epileptic Patients. Online. In \textit{43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society}. 30 10 2021. Neuveden: IEEE, 2021, p.~5816-5819. ISSN~2375-7477. Available from: https://dx.doi.org/10.1109/EMBC46164.2021.9629577.

Detailed Information on Publication Record