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@article{1828897,
author = {Svěrák, Tomáš and Linhartová, Pavla and Gajdoš, Martin and Kuhn, Matyáš and Látalová, Adéla and Lamoš, Martin and Ustohal, Libor and Kašpárek, Tomáš},
article_location = {Lausanne},
article_number = {January 2022},
doi = {http://dx.doi.org/10.3389/fpsyt.2021.770353},
keywords = {transcranial magnetic stimulation; borderline personality disorder; connectivity changes; Go/NoGo task; posterior default mode network},
language = {eng},
issn = {1664-0640},
journal = {Frontiers in Psychiatry},
title = {Brain Connectivity and Symptom Changes After Transcranial Magnetic Stimulation in Patients With Borderline Personality Disorder},
url = {https://www.frontiersin.org/articles/10.3389/fpsyt.2021.770353/full},
volume = {12},
year = {2022}
}
TY - JOUR
ID - 1828897
AU - Svěrák, Tomáš - Linhartová, Pavla - Gajdoš, Martin - Kuhn, Matyáš - Látalová, Adéla - Lamoš, Martin - Ustohal, Libor - Kašpárek, Tomáš
PY - 2022
TI - Brain Connectivity and Symptom Changes After Transcranial Magnetic Stimulation in Patients With Borderline Personality Disorder
JF - Frontiers in Psychiatry
VL - 12
IS - January 2022
SP - 1-10
EP - 1-10
PB - Frontiers
SN - 16640640
KW - transcranial magnetic stimulation
KW - borderline personality disorder
KW - connectivity changes
KW - Go/NoGo task
KW - posterior default mode network
UR - https://www.frontiersin.org/articles/10.3389/fpsyt.2021.770353/full
N2 - ObjectivesRepetitive transcranial magnetic stimulation (rTMS) is an innovative method in the treatment of borderline personality disorder (BPD). We hypothesized that prefrontal rTMS in patients with BPD leads to improved BPD symptoms and that these effects are associated with brain connectivity changes. MethodsFourteen patients with BPD received 15 sessions of individually navigated prefrontal rTMS over the right dorsolateral prefrontal cortex. Clinical effects were measured by the Borderline Symptom List 23, UPPS-P, the Difficulties in Emotion Regulation Scale (DERS), the Zung Self-Rating Anxiety Scale (SAS), and the Montgomery and angstrom sberg Depression Rating Scale (MADRS). Effects of rTMS on brain connectivity were observed with a seed correlation analysis on resting-state fMRI and with a beta series correlation analysis on Go/No Go tasks during fMRI. Assessments were made before and immediately after the treatment. ResultsThe assessments after rTMS showed significant reductions in two subscales of UPPS-P, and in DERS, SAS, and MADRS. The brain connectivity analysis revealed significant decreases in amygdala and insula connectivity with nodes of the posterior default mode network (pDMN; precuneus, posterior cingulate cortex, parietal lobules). Connectivity changes were observed both in the resting state and during inhibition. The decrease of amygdala-pDMN connectivity was positively correlated with reduced depression and lack of premeditation after rTMS. ConclusionsDespite the study limitations (open single-arm study in a small sample), our findings suggest a possible neural mechanism of rTMS effect in BPD, reduced amygdala connectivity with the pDMN network, which was positively associated with symptom reduction.
ER -
SVĚRÁK, Tomáš, Pavla LINHARTOVÁ, Martin GAJDOŠ, Matyáš KUHN, Adéla LÁTALOVÁ, Martin LAMOŠ, Libor USTOHAL and Tomáš KAŠPÁREK. Brain Connectivity and Symptom Changes After Transcranial Magnetic Stimulation in Patients With Borderline Personality Disorder. \textit{Frontiers in Psychiatry}. Lausanne: Frontiers, 2022, vol.~12, January 2022, p.~1-10. ISSN~1664-0640. Available from: https://dx.doi.org/10.3389/fpsyt.2021.770353.
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