J 2021

Constitutive models and failure properties of fibrous tissues of carotid artery atheroma based on their uniaxial testing

LISICKY, Ondrej, Anna HRUBANOVA, Robert STAFFA, Robert VLACHOVSKÝ, Jiri BURSA et. al.

Basic information

Original name

Constitutive models and failure properties of fibrous tissues of carotid artery atheroma based on their uniaxial testing

Authors

LISICKY, Ondrej (203 Czech Republic, guarantor), Anna HRUBANOVA (203 Czech Republic), Robert STAFFA (203 Czech Republic, belonging to the institution), Robert VLACHOVSKÝ (203 Czech Republic, belonging to the institution) and Jiri BURSA (203 Czech Republic)

Edition

JOURNAL OF BIOMECHANICS, OXFORD, ELSEVIER SCI LTD, 2021, 0021-9290

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

20602 Medical laboratory technology ;

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 2.789

RIV identification code

RIV/00216224:14110/21:00123994

Organization unit

Faculty of Medicine

DOI

UT WoS

000719795600002

Keywords in English

Atherosclerosis; Carotid artery; Fibrous tissue; Strength; Uniaxial tension

Tags

Tags

International impact, Reviewed
Změněno: 31/1/2022 10:01, Mgr. Tereza Miškechová

Abstract

V originále

To obtain an experimental background for the description of mechanical properties of fibrous tissues of carotid atheroma, a cohort of 141 specimens harvested from 44 patients during endarterectomies, were tested. Uniaxial stress-strain curves and ultimate stress and strain at rupture were recorded. With this cohort, the impact of the direction of load, presence of calcifications, specimen location, patient's age and sex were investigated. A significant impact of sex was revealed for the stress-strain curves and ultimate strains. The response was significantly stiffer for females than for males but, in contrast to ultimate strain, the strength was not significantly different. The differences in strength between calcified and non-calcified atheromas have reached statistical significance in the female group. At most of the analysed stress levels, the loading direction was found significant for the male cohort which was also confirmed by large differences in ultimate strains. The representative uniaxial stress-strain curves (given by median values of strains at chosen stress levels) were fitted with an isotropic hyperelastic model for different groups specified by the investigated factors while the observed differences between circumferential and longitudinal direction were captured by an anisotropic hyperelastic model. The obtained results should be valid also for the tissue of the fibrous cap, the rupture of which is to be predicted in clinics using computational modelling because it may induce arterial thrombosis and consequently a brain stroke.