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@article{1829378,
author = {Liskova, A. and Samec, M. and Koklesova, L. and SamuelSM, S. M. and Zhai, K. V. and AlandIshaq, R. K. and Abotaleb, M. and Nosal, V. and Kajo, K. and Ashrafizadeh, M. and Zarrabi, A. and Brockmueller, A. and Shakibaei, M. and Sabaka, P. and Mozos, I. and Ullrich, D. and Prosecký, Robert and La Rocca, G. and Caprnda, M. and Busselberg, D. and Rodrigo, L. and Kružliak, Peter and Kubatka, P.},
article_location = {Paris},
article_number = {June 2021},
doi = {http://dx.doi.org/10.1016/j.biopha.2021.111430},
keywords = {SARS-CoV-2; COVID-19; Inflammation; Cytokine storm; Phytochemicals; Flavonoids; Immunomodulation; Anti-inflammatory effects},
language = {eng},
issn = {0753-3322},
journal = {BIOMEDICINE & PHARMACOTHERAPY},
title = {Flavonoids against the SARS-CoV-2 induced inflammatory storm},
url = {https://www.sciencedirect.com/science/article/pii/S0753332221002158?via%3Dihub},
volume = {138},
year = {2021}
}
TY - JOUR
ID - 1829378
AU - Liskova, A. - Samec, M. - Koklesova, L. - SamuelSM, S. M. - Zhai, K. V. - Al-Ishaq, R. K. - Abotaleb, M. - Nosal, V. - Kajo, K. - Ashrafizadeh, M. - Zarrabi, A. - Brockmueller, A. - Shakibaei, M. - Sabaka, P. - Mozos, I. - Ullrich, D. - Prosecký, Robert - La Rocca, G. - Caprnda, M. - Busselberg, D. - Rodrigo, L. - Kružliak, Peter - Kubatka, P.
PY - 2021
TI - Flavonoids against the SARS-CoV-2 induced inflammatory storm
JF - BIOMEDICINE & PHARMACOTHERAPY
VL - 138
IS - June 2021
SP - 1-12
EP - 1-12
PB - ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
SN - 07533322
KW - SARS-CoV-2
KW - COVID-19
KW - Inflammation
KW - Cytokine storm
KW - Phytochemicals
KW - Flavonoids
KW - Immunomodulation
KW - Anti-inflammatory effects
UR - https://www.sciencedirect.com/science/article/pii/S0753332221002158?via%3Dihub
N2 - The disease severity of COVID-19, especially in the elderly and patients with co-morbidities, is characterized by hypercytokinemia, an exaggerated immune response associated with an uncontrolled and excessive release of proinflammatory cytokine mediators (cytokine storm). Flavonoids, important secondary metabolites of plants, have long been studied as therapeutic interventions in inflammatory diseases due to their cytokine-modulatory effects. In this review, we discuss the potential role of flavonoids in the modulation of signaling pathways that are crucial for COVID-19 disease, particularly those related to inflammation and immunity. The immunomodulatory ability of flavonoids, carried out by the regulation of inflammatory mediators, the inhibition of endothelial activation, NLRP3 inflammasome, toll-like receptors (TLRs) or bromodomain containing protein 4 (BRD4), and the activation of the nuclear factor erythroid-derived 2-related factor 2 (Nrf2), might be beneficial in regulating the cytokine storm during SARS-CoV-2 infection. Moreover, the ability of flavonoids to inhibit dipeptidyl peptidase 4 (DPP4), neutralize 3-chymotrypsin-like protease (3CL(pro)) or to affect gut microbiota to maintain immune response, and the dual action of angiotensin-converting enzyme 2 (ACE-2) may potentially also be applied to the exaggerated inflammatory responses induced by SARS-CoV-2. Based on the previously proven effects of flavonoids in other diseases or on the basis of newly published studies associated with COVID-19 (bioinformatics, molecular docking), it is reasonable to assume positive effects of flavonoids on inflammatory changes associated with COVID-19. This review highlights the current state of knowledge of the utility of
ER -
LISKOVA, A., M. SAMEC, L. KOKLESOVA, S. M. SAMUELSM, K. V. ZHAI, R. K. AL-ISHAQ, M. ABOTALEB, V. NOSAL, K. KAJO, M. ASHRAFIZADEH, A. ZARRABI, A. BROCKMUELLER, M. SHAKIBAEI, P. SABAKA, I. MOZOS, D. ULLRICH, Robert PROSECKÝ, G. LA ROCCA, M. CAPRNDA, D. BUSSELBERG, L. RODRIGO, Peter KRUŽLIAK and P. KUBATKA. Flavonoids against the SARS-CoV-2 induced inflammatory storm. \textit{BIOMEDICINE \&{} PHARMACOTHERAPY}. Paris: ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2021, vol.~138, June 2021, p.~1-12. ISSN~0753-3322. Available from: https://dx.doi.org/10.1016/j.biopha.2021.111430.
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