Umbilical Cord Mesenchymal Stromal Cells for Cartilage
Regeneration Applications

J 2022

Umbilical Cord Mesenchymal Stromal Cells for Cartilage Regeneration Applications

RUSSO, E., M. CAPRNDA, Peter KRUŽLIAK, P. G. CONALDI, C. V. BORLONGAN et. al.

Basic information

Original name

Umbilical Cord Mesenchymal Stromal Cells for Cartilage Regeneration Applications

Authors

RUSSO, E., M. CAPRNDA, Peter KRUŽLIAK (703 Slovakia, belonging to the institution), P. G. CONALDI, C. V. BORLONGAN and G. LA ROCCA (guarantor)

Edition

Stem Cells International, London, HINDAWI LTD, 2022, 1687-966X

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10601 Cell biology

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.300

RIV identification code

RIV/00216224:14110/22:00125317

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1155/2022/2454168

UT WoS

000745969900002

Keywords in English

Umbilical Cord Mesenchymal Stromal Cells; Cartilage Regeneration Applications

Abstract

V originále

Chondropathies are increasing worldwide, but effective treatments are currently lacking. Mesenchymal stromal cell (MSCs) transplantation represents a promising approach to counteract the degenerative and inflammatory environment characterizing those pathologies, such as osteoarthritis (OA) and rheumatoid arthritis (RA). Umbilical cord- (UC-) MSCs gained increasing interest due to their multilineage differentiation potential, immunomodulatory, and anti-inflammatory properties as well as higher proliferation rates, abundant supply along with no risks for the donor compared to adult MSCs. In addition, UC-MSCs are physiologically adapted to survive in an ischemic and nutrient-poor environment as well as to produce an extracellular matrix (ECM) similar to that of the cartilage. All these characteristics make UC-MSCs a pivotal source for a stem cell-based treatment of chondropathies. In this review, the regenerative potential of UC-MSCs for the treatment of cartilage diseases will be discussed focusing on in vitro, in vivo, and clinical studies.

Citovat

RUSSO, E., M. CAPRNDA, Peter KRUŽLIAK, P. G. CONALDI, C. V. BORLONGAN and G. LA ROCCA. Umbilical Cord Mesenchymal Stromal Cells for Cartilage Regeneration Applications. Stem Cells International. London: HINDAWI LTD, 2022, vol. 2022, January 2022, p. 1-23. ISSN 1687-966X. Available from: https://dx.doi.org/10.1155/2022/2454168.

@article{1829389,
   author = {Russo, E. and Caprnda, M. and Kružliak, Peter and Conaldi, P. G. and Borlongan, C. V. and La Rocca, G.},
   article_location = {London},
   article_number = {January 2022},
   doi = {http://dx.doi.org/10.1155/2022/2454168},
   keywords = {Umbilical Cord Mesenchymal Stromal Cells; Cartilage Regeneration Applications},
   language = {eng},
   issn = {1687-966X},
   journal = {Stem Cells International},
   title = {Umbilical Cord Mesenchymal Stromal Cells for Cartilage Regeneration Applications},
   url = {https://www.hindawi.com/journals/sci/2022/2454168/},
   volume = {2022},
   year = {2022}
}

TY  - JOUR
ID  - 1829389
AU  - Russo, E. - Caprnda, M. - Kružliak, Peter - Conaldi, P. G. - Borlongan, C. V. - La Rocca, G.
PY  - 2022
TI  - Umbilical Cord Mesenchymal Stromal Cells for Cartilage Regeneration Applications
JF  - Stem Cells International
VL  - 2022
IS  - January 2022
SP  - 1-23
EP  - 1-23
PB  - HINDAWI LTD
SN  - 1687966X
KW  - Umbilical Cord Mesenchymal Stromal Cells
KW  - Cartilage Regeneration Applications
UR  - https://www.hindawi.com/journals/sci/2022/2454168/
N2  - Chondropathies are increasing worldwide, but effective treatments are currently lacking. Mesenchymal stromal cell (MSCs) transplantation represents a promising approach to counteract the degenerative and inflammatory environment characterizing those pathologies, such as osteoarthritis (OA) and rheumatoid arthritis (RA). Umbilical cord- (UC-) MSCs gained increasing interest due to their multilineage differentiation potential, immunomodulatory, and anti-inflammatory properties as well as higher proliferation rates, abundant supply along with no risks for the donor compared to adult MSCs. In addition, UC-MSCs are physiologically adapted to survive in an ischemic and nutrient-poor environment as well as to produce an extracellular matrix (ECM) similar to that of the cartilage. All these characteristics make UC-MSCs a pivotal source for a stem cell-based treatment of chondropathies. In this review, the regenerative potential of UC-MSCs for the treatment of cartilage diseases will be discussed focusing on in vitro, in vivo, and clinical studies.
ER  -

RUSSO, E., M. CAPRNDA, Peter KRUŽLIAK, P. G. CONALDI, C. V. BORLONGAN and G. LA ROCCA. Umbilical Cord Mesenchymal Stromal Cells for Cartilage Regeneration Applications. \textit{Stem Cells International}. London: HINDAWI LTD, 2022, vol.~2022, January 2022, p.~1-23. ISSN~1687-966X. Available from: https://dx.doi.org/10.1155/2022/2454168.

Detailed Information on Publication Record