RUSSO, E., M. CAPRNDA, Peter KRUŽLIAK, P. G. CONALDI, C. V. BORLONGAN and G. LA ROCCA. Umbilical Cord Mesenchymal Stromal Cells for Cartilage Regeneration Applications. Stem Cells International. London: HINDAWI LTD, 2022, vol. 2022, January 2022, p. 1-23. ISSN 1687-966X. Available from: https://dx.doi.org/10.1155/2022/2454168.
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Basic information
Original name Umbilical Cord Mesenchymal Stromal Cells for Cartilage Regeneration Applications
Authors RUSSO, E., M. CAPRNDA, Peter KRUŽLIAK (703 Slovakia, belonging to the institution), P. G. CONALDI, C. V. BORLONGAN and G. LA ROCCA (guarantor).
Edition Stem Cells International, London, HINDAWI LTD, 2022, 1687-966X.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 10601 Cell biology
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 4.300
RIV identification code RIV/00216224:14110/22:00125317
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1155/2022/2454168
UT WoS 000745969900002
Keywords in English Umbilical Cord Mesenchymal Stromal Cells; Cartilage Regeneration Applications
Tags 14110121, rivok
Tags International impact, Reviewed
Changed by Changed by: Mgr. Tereza Miškechová, učo 341652. Changed: 31/1/2022 10:37.
Abstract
Chondropathies are increasing worldwide, but effective treatments are currently lacking. Mesenchymal stromal cell (MSCs) transplantation represents a promising approach to counteract the degenerative and inflammatory environment characterizing those pathologies, such as osteoarthritis (OA) and rheumatoid arthritis (RA). Umbilical cord- (UC-) MSCs gained increasing interest due to their multilineage differentiation potential, immunomodulatory, and anti-inflammatory properties as well as higher proliferation rates, abundant supply along with no risks for the donor compared to adult MSCs. In addition, UC-MSCs are physiologically adapted to survive in an ischemic and nutrient-poor environment as well as to produce an extracellular matrix (ECM) similar to that of the cartilage. All these characteristics make UC-MSCs a pivotal source for a stem cell-based treatment of chondropathies. In this review, the regenerative potential of UC-MSCs for the treatment of cartilage diseases will be discussed focusing on in vitro, in vivo, and clinical studies.
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