The Role of ATRA, Natural Ligand of Retinoic Acid Receptors, on
EMT-Related Proteins in Breast Cancer: Minireview

J 2021

The Role of ATRA, Natural Ligand of Retinoic Acid Receptors, on EMT-Related Proteins in Breast Cancer: Minireview

BOBÁĽ, Pavel, M. LASTOVICKOVA and J. BOBALOVA

Basic information

Original name

The Role of ATRA, Natural Ligand of Retinoic Acid Receptors, on EMT-Related Proteins in Breast Cancer: Minireview

Authors

BOBÁĽ, Pavel (703 Slovakia, belonging to the institution), M. LASTOVICKOVA and J. BOBALOVA (guarantor)

Edition

International Journal of Molecular Sciences, Basel, Multidisciplinary Digital Publishing Institute, 2021, 1422-0067

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 6.208

RIV identification code

RIV/00216224:14160/21:00124008

Organization unit

Faculty of Pharmacy

DOI

http://dx.doi.org/10.3390/ijms222413345

UT WoS

000738236600001

Keywords in English

breast cancer; EMT; protein; ATRA

Abstract

V originále

The knowledge of the structure, function, and abundance of specific proteins related to the EMT process is essential for developing effective diagnostic approaches to cancer with the perspective of diagnosis and therapy of malignancies. The success of all-trans retinoic acid (ATRA) differentiation therapy in acute promyelocytic leukemia has stimulated studies in the treatment of other tumors with ATRA. This review will discuss the impact of ATRA use, emphasizing epithelial-mesenchymal transition (EMT) proteins in breast cancer, of which metastasis and recurrence are major causes of death.

Links

MUNI/A/1682/2020, interní kód MU

Name: Návrh, syntéza a hodnocení derivátů skupin léčiv s inhibiční enzymatickou aktivitou

Investor: Masaryk University

Citovat

BOBÁĽ, Pavel, M. LASTOVICKOVA and J. BOBALOVA. The Role of ATRA, Natural Ligand of Retinoic Acid Receptors, on EMT-Related Proteins in Breast Cancer: Minireview. International Journal of Molecular Sciences. Basel: Multidisciplinary Digital Publishing Institute, 2021, vol. 22, No 24, p. 1-18. ISSN 1422-0067. Available from: https://dx.doi.org/10.3390/ijms222413345.

@article{1829630,
   author = {Bobáľ, Pavel and Lastovickova, M. and Bobalova, J.},
   article_location = {Basel},
   article_number = {24},
   doi = {http://dx.doi.org/10.3390/ijms222413345},
   keywords = {breast cancer; EMT; protein; ATRA},
   language = {eng},
   issn = {1422-0067},
   journal = {International Journal of Molecular Sciences},
   title = {The Role of ATRA, Natural Ligand of Retinoic Acid Receptors, on EMT-Related Proteins in Breast Cancer: Minireview},
   url = {https://www.mdpi.com/1422-0067/22/24/13345/htm},
   volume = {22},
   year = {2021}
}

TY  - JOUR
ID  - 1829630
AU  - Bobáľ, Pavel - Lastovickova, M. - Bobalova, J.
PY  - 2021
TI  - The Role of ATRA, Natural Ligand of Retinoic Acid Receptors, on EMT-Related Proteins in Breast Cancer: Minireview
JF  - International Journal of Molecular Sciences
VL  - 22
IS  - 24
SP  - 1-18
EP  - 1-18
PB  - Multidisciplinary Digital Publishing Institute
SN  - 14220067
KW  - breast cancer
KW  - EMT
KW  - protein
KW  - ATRA
UR  - https://www.mdpi.com/1422-0067/22/24/13345/htm
N2  - The knowledge of the structure, function, and abundance of specific proteins related to the EMT process is essential for developing effective diagnostic approaches to cancer with the perspective of diagnosis and therapy of malignancies. The success of all-trans retinoic acid (ATRA) differentiation therapy in acute promyelocytic leukemia has stimulated studies in the treatment of other tumors with ATRA. This review will discuss the impact of ATRA use, emphasizing epithelial-mesenchymal transition (EMT) proteins in breast cancer, of which metastasis and recurrence are major causes of death.
ER  -

BOBÁĽ, Pavel, M. LASTOVICKOVA and J. BOBALOVA. The Role of ATRA, Natural Ligand of Retinoic Acid Receptors, on EMT-Related Proteins in Breast Cancer: Minireview. \textit{International Journal of Molecular Sciences}. Basel: Multidisciplinary Digital Publishing Institute, 2021, vol.~22, No~24, p.~1-18. ISSN~1422-0067. Available from: https://dx.doi.org/10.3390/ijms222413345.

Detailed Information on Publication Record