Oxidative Stress in the Brain: Basic Concepts and Treatment
Strategies in Stroke

J 2021

Oxidative Stress in the Brain: Basic Concepts and Treatment Strategies in Stroke

JELÍNEK, Matyáš, Michal JURAJDA and Kamil ĎURIŠ

Basic information

Original name

Oxidative Stress in the Brain: Basic Concepts and Treatment Strategies in Stroke

Authors

JELÍNEK, Matyáš (203 Czech Republic, belonging to the institution), Michal JURAJDA (203 Czech Republic, belonging to the institution) and Kamil ĎURIŠ (203 Czech Republic, guarantor, belonging to the institution)

Edition

Antioxidants, Basel, MDPI, 2021, 2076-3921

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 7.675

RIV identification code

RIV/00216224:14110/21:00124015

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.3390/antiox10121886

UT WoS

000735841100001

Keywords in English

oxidative stress; free radicals; ROS; RNS; brain; stroke; antioxidants; scavengers

Abstract

V originále

The production of free radicals is inevitably associated with metabolism and other enzymatic processes. Under physiological conditions, however, free radicals are effectively eliminated by numerous antioxidant mechanisms. Oxidative stress occurs due to an imbalance between the production and elimination of free radicals under pathological conditions. Oxidative stress is also associated with ageing. The brain is prone to oxidative damage because of its high metabolic activity and high vulnerability to ischemic damage. Oxidative stress, thus, plays a major role in the pathophysiology of both acute and chronic pathologies in the brain, such as stroke, traumatic brain injury or neurodegenerative diseases. The goal of this article is to summarize the basic concepts of oxidative stress and its significance in brain pathologies, as well as to discuss treatment strategies for dealing with oxidative stress in stroke.

Links

MUNI/A/1698/2020, interní kód MU

Name: Od molekulární, buněčné a tkáňové k systémové patofyziologii vybraných komplexních nemocí (Acronym: ComplexPF)

Investor: Masaryk University

MUNI/11/SUP/24/2020, interní kód MU

Name: Pilotní studie ke studiu role cytokinů z rodiny interleukinu 6 a možnosti potlačení zánětu pomocí stimulace nervus vagus u experimentálního modelu subarachnoidálního krvácení a sepse (Acronym: Rodina IL-6 a SAH)

Investor: Masaryk University

Citovat

JELÍNEK, Matyáš, Michal JURAJDA and Kamil ĎURIŠ. Oxidative Stress in the Brain: Basic Concepts and Treatment Strategies in Stroke. Antioxidants. Basel: MDPI, 2021, vol. 10, No 12, p. 1-12. ISSN 2076-3921. Available from: https://dx.doi.org/10.3390/antiox10121886.

@article{1830177,
   author = {Jelínek, Matyáš and Jurajda, Michal and Ďuriš, Kamil},
   article_location = {Basel},
   article_number = {12},
   doi = {http://dx.doi.org/10.3390/antiox10121886},
   keywords = {oxidative stress; free radicals; ROS; RNS; brain; stroke; antioxidants; scavengers},
   language = {eng},
   issn = {2076-3921},
   journal = {Antioxidants},
   title = {Oxidative Stress in the Brain: Basic Concepts and Treatment Strategies in Stroke},
   url = {https://www.mdpi.com/2076-3921/10/12/1886},
   volume = {10},
   year = {2021}
}

TY  - JOUR
ID  - 1830177
AU  - Jelínek, Matyáš - Jurajda, Michal - Ďuriš, Kamil
PY  - 2021
TI  - Oxidative Stress in the Brain: Basic Concepts and Treatment Strategies in Stroke
JF  - Antioxidants
VL  - 10
IS  - 12
SP  - 1-12
EP  - 1-12
PB  - MDPI
SN  - 20763921
KW  - oxidative stress
KW  - free radicals
KW  - ROS
KW  - RNS
KW  - brain
KW  - stroke
KW  - antioxidants
KW  - scavengers
UR  - https://www.mdpi.com/2076-3921/10/12/1886
N2  - The production of free radicals is inevitably associated with metabolism and other enzymatic processes. Under physiological conditions, however, free radicals are effectively eliminated by numerous antioxidant mechanisms. Oxidative stress occurs due to an imbalance between the production and elimination of free radicals under pathological conditions. Oxidative stress is also associated with ageing. The brain is prone to oxidative damage because of its high metabolic activity and high vulnerability to ischemic damage. Oxidative stress, thus, plays a major role in the pathophysiology of both acute and chronic pathologies in the brain, such as stroke, traumatic brain injury or neurodegenerative diseases. The goal of this article is to summarize the basic concepts of oxidative stress and its significance in brain pathologies, as well as to discuss treatment strategies for dealing with oxidative stress in stroke.
ER  -

JELÍNEK, Matyáš, Michal JURAJDA and Kamil ĎURIŠ. Oxidative Stress in the Brain: Basic Concepts and Treatment Strategies in Stroke. \textit{Antioxidants}. Basel: MDPI, 2021, vol.~10, No~12, p.~1-12. ISSN~2076-3921. Available from: https://dx.doi.org/10.3390/antiox10121886.

Detailed Information on Publication Record