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@article{1830177,
author = {Jelínek, Matyáš and Jurajda, Michal and Ďuriš, Kamil},
article_location = {Basel},
article_number = {12},
doi = {http://dx.doi.org/10.3390/antiox10121886},
keywords = {oxidative stress; free radicals; ROS; RNS; brain; stroke; antioxidants; scavengers},
language = {eng},
issn = {2076-3921},
journal = {Antioxidants},
title = {Oxidative Stress in the Brain: Basic Concepts and Treatment Strategies in Stroke},
url = {https://www.mdpi.com/2076-3921/10/12/1886},
volume = {10},
year = {2021}
}
TY - JOUR
ID - 1830177
AU - Jelínek, Matyáš - Jurajda, Michal - Ďuriš, Kamil
PY - 2021
TI - Oxidative Stress in the Brain: Basic Concepts and Treatment Strategies in Stroke
JF - Antioxidants
VL - 10
IS - 12
SP - 1-12
EP - 1-12
PB - MDPI
SN - 20763921
KW - oxidative stress
KW - free radicals
KW - ROS
KW - RNS
KW - brain
KW - stroke
KW - antioxidants
KW - scavengers
UR - https://www.mdpi.com/2076-3921/10/12/1886
N2 - The production of free radicals is inevitably associated with metabolism and other enzymatic processes. Under physiological conditions, however, free radicals are effectively eliminated by numerous antioxidant mechanisms. Oxidative stress occurs due to an imbalance between the production and elimination of free radicals under pathological conditions. Oxidative stress is also associated with ageing. The brain is prone to oxidative damage because of its high metabolic activity and high vulnerability to ischemic damage. Oxidative stress, thus, plays a major role in the pathophysiology of both acute and chronic pathologies in the brain, such as stroke, traumatic brain injury or neurodegenerative diseases. The goal of this article is to summarize the basic concepts of oxidative stress and its significance in brain pathologies, as well as to discuss treatment strategies for dealing with oxidative stress in stroke.
ER -
JELÍNEK, Matyáš, Michal JURAJDA and Kamil ĎURIŠ. Oxidative Stress in the Brain: Basic Concepts and Treatment Strategies in Stroke. \textit{Antioxidants}. Basel: MDPI, vol.~10, No~12, p.~1-12. ISSN~2076-3921. doi:10.3390/antiox10121886. 2021.
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