| PIŽEM, Dominik, Ľubomíra NOVÁKOVÁ, Martin GAJDOŠ and Irena REKTOROVÁ. Is the vertex a good control stimulation site? Theta burst stimulation in healthy controls. Journal of Neural Transmission. Springer, 2022, vol. 129, No 3, p. 319-329. ISSN 0300-9564. Available from: https://dx.doi.org/10.1007/s00702-022-02466-9. |
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@article{1830201,
author = {Pižem, Dominik and Nováková, Ľubomíra and Gajdoš, Martin and Rektorová, Irena},
article_number = {3},
doi = {http://dx.doi.org/10.1007/s00702-022-02466-9},
keywords = {Cognitive; Control condition; SimNIBS; Transcranial magnetic stimulation; Vertex stimulation; rTMS},
language = {eng},
issn = {0300-9564},
journal = {Journal of Neural Transmission},
title = {Is the vertex a good control stimulation site? Theta burst stimulation in healthy controls},
url = {https://link.springer.com/content/pdf/10.1007/s00702-022-02466-9.pdf},
volume = {129},
year = {2022}
}
TY - JOUR
ID - 1830201
AU - Pižem, Dominik - Nováková, Ľubomíra - Gajdoš, Martin - Rektorová, Irena
PY - 2022
TI - Is the vertex a good control stimulation site? Theta burst stimulation in healthy controls
JF - Journal of Neural Transmission
VL - 129
IS - 3
SP - 319-329
EP - 319-329
PB - Springer
SN - 03009564
KW - Cognitive
KW - Control condition
KW - SimNIBS
KW - Transcranial magnetic stimulation
KW - Vertex stimulation
KW - rTMS
UR - https://link.springer.com/content/pdf/10.1007/s00702-022-02466-9.pdf
N2 - The vertex has been used as a suitable control stimulation site in repetitive transcranial magnetic stimulation studies. The objectives of this study are (1) to assess cognitive performance (CP) after theta burst stimulation (TBS); (2) to evaluate whether clinically relevant cortical areas might be reached by vertex stimulation and how that might influence CP. Twenty young healthy subjects performed a cognitive task prior to and immediately after intermittent TBS (iTBS) and continuous TBS (cTBS) of two active cortical stimulation sites and the vertex. We used the Wilcoxon signed-rank test to compare the pre- and post-stimulation reaction times (RTs) and a mixed ANOVA analysis to evaluate the effect of the stimulation on changes in RTs. A three-dimensional finite-element model (FEM) was used to calculate the vertex TBS-induced electrical field (E-field) in the adjacent regions of interest (ROIs). Correlation analyses were performed between E-fields in the ROIs and cognitive outcomes. We found a significant effect only of the stimulation time factor (F (1,12) = 65.37, p < 0.001) on RT shortening, with no superiority of the active site stimulation compared to the vertex stimulation. In 73.5% of vertex TBS sessions, a significant E-field was induced in at least one ROI. We found a negative association between the magnitude of the iTBS-induced E-fields and RT changes (R = - 0.54, p = 0.04). TBS protocols may lead to changes in CP when applied over the craniometrically targeted vertex. We therefore suggest not using a conventional approach as a vertex targeting method.
ER -
PIŽEM, Dominik, Ľubomíra NOVÁKOVÁ, Martin GAJDOŠ and Irena REKTOROVÁ. Is the vertex a good control stimulation site? Theta burst stimulation in healthy controls. \textit{Journal of Neural Transmission}. Springer, 2022, vol.~129, No~3, p.~319-329. ISSN~0300-9564. Available from: https://dx.doi.org/10.1007/s00702-022-02466-9.
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