J 2022

Is the vertex a good control stimulation site? Theta burst stimulation in healthy controls

PIŽEM, Dominik, Ľubomíra NOVÁKOVÁ, Martin GAJDOŠ and Irena REKTOROVÁ

Basic information

Original name

Is the vertex a good control stimulation site? Theta burst stimulation in healthy controls

Authors

PIŽEM, Dominik (703 Slovakia, belonging to the institution), Ľubomíra NOVÁKOVÁ (703 Slovakia, belonging to the institution), Martin GAJDOŠ (203 Czech Republic, belonging to the institution) and Irena REKTOROVÁ (203 Czech Republic, guarantor, belonging to the institution)

Edition

Journal of Neural Transmission, Springer, 2022, 0300-9564

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30103 Neurosciences

Country of publisher

Austria

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 3.300

RIV identification code

RIV/00216224:14740/22:00125326

Organization unit

Central European Institute of Technology

DOI

UT WoS

000746752700001

Keywords (in Czech)

Kognice, kontrolní podmínka, SimNIBS, Trankraniální magnetická stimulace, stimulace vertexu, rTMS

Keywords in English

Cognitive; Control condition; SimNIBS; Transcranial magnetic stimulation; Vertex stimulation; rTMS

Tags

Tags

International impact, Reviewed
Změněno: 10/10/2024 10:25, Ing. Jana Kuchtová

Abstract

V originále

The vertex has been used as a suitable control stimulation site in repetitive transcranial magnetic stimulation studies. The objectives of this study are (1) to assess cognitive performance (CP) after theta burst stimulation (TBS); (2) to evaluate whether clinically relevant cortical areas might be reached by vertex stimulation and how that might influence CP. Twenty young healthy subjects performed a cognitive task prior to and immediately after intermittent TBS (iTBS) and continuous TBS (cTBS) of two active cortical stimulation sites and the vertex. We used the Wilcoxon signed-rank test to compare the pre- and post-stimulation reaction times (RTs) and a mixed ANOVA analysis to evaluate the effect of the stimulation on changes in RTs. A three-dimensional finite-element model (FEM) was used to calculate the vertex TBS-induced electrical field (E-field) in the adjacent regions of interest (ROIs). Correlation analyses were performed between E-fields in the ROIs and cognitive outcomes. We found a significant effect only of the stimulation time factor (F (1,12) = 65.37, p < 0.001) on RT shortening, with no superiority of the active site stimulation compared to the vertex stimulation. In 73.5% of vertex TBS sessions, a significant E-field was induced in at least one ROI. We found a negative association between the magnitude of the iTBS-induced E-fields and RT changes (R = - 0.54, p = 0.04). TBS protocols may lead to changes in CP when applied over the craniometrically targeted vertex. We therefore suggest not using a conventional approach as a vertex targeting method.

Links

GF21-13462L, research and development project
Name: Nové individualizované přístupy mozkové stimulace založené na synchronizaci v mozkových sítích pro zlepšení kognice zdravých seniorů a pacientů s MCI
Investor: Czech Science Foundation, Novel individualized brain stimulation network-based approaches to improve cognition in healthy seniors and patients with MCI, Partner Agency (Switzerland)
NV16-31868A, research and development project
Name: Ovlivnění kognitivních funkcí a konektivity mozku pomocí neinvazivní mozkové stimulace u pacientů s mírnou kognitivní poruchou u Alzheimerovy choroby
90129, large research infrastructures
Name: Czech-BioImaging II