High CD4-to-CD8 ratio identifies an at-risk population
susceptible to lethal COVID-19

J 2022

High CD4-to-CD8 ratio identifies an at-risk population susceptible to lethal COVID-19

ZUANI DE, Marco, Petra LÁZNIČKOVÁ, Veronika TOMÁŠKOVÁ, Martina DVONČOVÁ, Giancarlo FORTE et. al.

Basic information

Original name

High CD4-to-CD8 ratio identifies an at-risk population susceptible to lethal COVID-19

Authors

ZUANI DE, Marco, Petra LÁZNIČKOVÁ (203 Czech Republic, belonging to the institution), Veronika TOMÁŠKOVÁ (203 Czech Republic, belonging to the institution), Martina DVONČOVÁ (703 Slovakia, belonging to the institution), Giancarlo FORTE (380 Italy), Gorazd Bernard STOKIN, Vladimír ŠRÁMEK (203 Czech Republic, belonging to the institution), Martin HELÁN (203 Czech Republic, belonging to the institution) and Jan FRIČ (203 Czech Republic, guarantor)

Edition

Scandinavian journal of immunology, HOBOKEN, WILEY, 2022, 0300-9475

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30102 Immunology

Country of publisher

Slovenia

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.700

RIV identification code

RIV/00216224:14110/22:00125332

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1111/sji.13125

UT WoS

000729621000001

Keywords in English

CD4-to-CD8 ratio; COVID-19; Intensive care unit; SARS-CoV-2; T cells; TEMRA

Abstract

V originále

Around half of people with severe COVID-19 requiring intensive care unit (ICU) treatment will survive, but it is unclear how the immune response to SARS-CoV-2 differs between ICU patients that recover and those that do not. We conducted whole-blood immunophenotyping of COVID-19 patients upon admission to ICU and during their treatment and uncovered marked differences in their circulating immune cell subsets. At admission, patients who later succumbed to COVID-19 had significantly lower frequencies of all memory CD8+ T cell subsets, resulting in increased CD4-to-CD8 T cell and neutrophil-to-CD8 T cell ratios. ROC and Kaplan-Meier analyses demonstrated that both CD4-to-CD8 and neutrophil-to-CD8 ratios at admission were strong predictors of in-ICU mortality. Therefore, we propose the use of the CD4-to-CD8 T cell ratio as a marker for the early identification of those individuals likely to require enhanced monitoring and/or pro-active intervention in ICU.

Citovat

ZUANI DE, Marco, Petra LÁZNIČKOVÁ, Veronika TOMÁŠKOVÁ, Martina DVONČOVÁ, Giancarlo FORTE, Gorazd Bernard STOKIN, Vladimír ŠRÁMEK, Martin HELÁN and Jan FRIČ. High CD4-to-CD8 ratio identifies an at-risk population susceptible to lethal COVID-19. Scandinavian journal of immunology. HOBOKEN: WILEY, 2022, vol. 95, No 3, p. 1-11. ISSN 0300-9475. Available from: https://dx.doi.org/10.1111/sji.13125.

@article{1830717,
   author = {Zuani De, Marco and Lázničková, Petra and Tomášková, Veronika and Dvončová, Martina and Forte, Giancarlo and Stokin, Gorazd Bernard and Šrámek, Vladimír and Helán, Martin and Frič, Jan},
   article_location = {HOBOKEN},
   article_number = {3},
   doi = {http://dx.doi.org/10.1111/sji.13125},
   keywords = {CD4-to-CD8 ratio; COVID-19; Intensive care unit; SARS-CoV-2; T cells; TEMRA},
   language = {eng},
   issn = {0300-9475},
   journal = {Scandinavian journal of immunology},
   title = {High CD4-to-CD8 ratio identifies an at-risk population susceptible to lethal COVID-19},
   url = {https://onlinelibrary.wiley.com/doi/10.1111/sji.13125},
   volume = {95},
   year = {2022}
}

TY  - JOUR
ID  - 1830717
AU  - Zuani De, Marco - Lázničková, Petra - Tomášková, Veronika - Dvončová, Martina - Forte, Giancarlo - Stokin, Gorazd Bernard - Šrámek, Vladimír - Helán, Martin - Frič, Jan
PY  - 2022
TI  - High CD4-to-CD8 ratio identifies an at-risk population susceptible to lethal COVID-19
JF  - Scandinavian journal of immunology
VL  - 95
IS  - 3
SP  - 1-11
EP  - 1-11
PB  - WILEY
SN  - 03009475
KW  - CD4-to-CD8 ratio
KW  - COVID-19
KW  - Intensive care unit
KW  - SARS-CoV-2
KW  - T cells
KW  - TEMRA
UR  - https://onlinelibrary.wiley.com/doi/10.1111/sji.13125
N2  - Around half of people with severe COVID-19 requiring intensive care unit (ICU) treatment will survive, but it is unclear how the immune response to SARS-CoV-2 differs between ICU patients that recover and those that do not. We conducted whole-blood immunophenotyping of COVID-19 patients upon admission to ICU and during their treatment and uncovered marked differences in their circulating immune cell subsets. At admission, patients who later succumbed to COVID-19 had significantly lower frequencies of all memory CD8+ T cell subsets, resulting in increased CD4-to-CD8 T cell and neutrophil-to-CD8 T cell ratios. ROC and Kaplan-Meier analyses demonstrated that both CD4-to-CD8 and neutrophil-to-CD8 ratios at admission were strong predictors of in-ICU mortality. Therefore, we propose the use of the CD4-to-CD8 T cell ratio as a marker for the early identification of those individuals likely to require enhanced monitoring and/or pro-active intervention in ICU.
ER  -

ZUANI DE, Marco, Petra LÁZNIČKOVÁ, Veronika TOMÁŠKOVÁ, Martina DVONČOVÁ, Giancarlo FORTE, Gorazd Bernard STOKIN, Vladimír ŠRÁMEK, Martin HELÁN and Jan FRIČ. High CD4-to-CD8 ratio identifies an at-risk population susceptible to lethal COVID-19. \textit{Scandinavian journal of immunology}. HOBOKEN: WILEY, 2022, vol.~95, No~3, p.~1-11. ISSN~0300-9475. Available from: https://dx.doi.org/10.1111/sji.13125.

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