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@article{1830719,
author = {Hortová Kohoutková, Marcela and Zuani De, Marco and Lázničková, Petra and Bendickova, Kamila and Mrkva, Ondřej and Andrejčinová, Ivana and Mýtniková, Alexandra and Polansky, Ondrej and Koci, Kamila and Tomášková, Veronika and Šrámek, Vladimír and Helán, Martin and Frič, Jan},
article_location = {LAUSANNE},
article_number = {December 2021},
doi = {http://dx.doi.org/10.3389/fimmu.2021.741484},
keywords = {sepsis; polymorphonuclears; septic shock; transcriptomics; proteomics; dysfunctionality},
language = {eng},
issn = {1664-3224},
journal = {Frontiers in Immunology},
title = {Polymorphonuclear Cells Show Features of Dysfunctional Activation During Fatal Sepsis},
url = {https://www.frontiersin.org/articles/10.3389/fimmu.2021.741484/full},
volume = {12},
year = {2021}
}
TY - JOUR
ID - 1830719
AU - Hortová Kohoutková, Marcela - Zuani De, Marco - Lázničková, Petra - Bendickova, Kamila - Mrkva, Ondřej - Andrejčinová, Ivana - Mýtniková, Alexandra - Polansky, Ondrej - Koci, Kamila - Tomášková, Veronika - Šrámek, Vladimír - Helán, Martin - Frič, Jan
PY - 2021
TI - Polymorphonuclear Cells Show Features of Dysfunctional Activation During Fatal Sepsis
JF - Frontiers in Immunology
VL - 12
IS - December 2021
SP - 1-12
EP - 1-12
PB - FRONTIERS MEDIA SA
SN - 16643224
KW - sepsis
KW - polymorphonuclears
KW - septic shock
KW - transcriptomics
KW - proteomics
KW - dysfunctionality
UR - https://www.frontiersin.org/articles/10.3389/fimmu.2021.741484/full
N2 - Sepsis and septic shock remain leading causes of morbidity and mortality for patients in the intensive care unit. During the early phase, immune cells produce various cytokines leading to prompt activation of the immune system. Polymorphonuclear leukocytes (PMNs) respond to different signals producing inflammatory factors and executing their antimicrobial mechanisms, resulting in the engulfment and elimination of invading pathogens. However, excessive activation caused by various inflammatory signals produced during sepsis progression can lead to the alteration of PMN signaling and subsequent defects in their functionality. Here, we analyzed samples from 34 patients in septic shock, focusing on PMNs gene expression and proteome changes associated with septic shock. We revealed that, compared to those patients who survived longer than five days, PMNs from patients who had fulminant sepsis were characterized by a dysfunctional hyper-activation, show altered metabolism, and recent exit from the cell cycle and signs of cellular lifespan. We believe that this multi-omics approach, although limited, pinpoints the alterations in PMNs' functionality, which may be rescued by targeted treatments.
ER -
HORTOVÁ KOHOUTKOVÁ, Marcela, Marco ZUANI DE, Petra LÁZNIČKOVÁ, Kamila BENDICKOVA, Ondřej MRKVA, Ivana ANDREJČINOVÁ, Alexandra MÝTNIKOVÁ, Ondrej POLANSKY, Kamila KOCI, Veronika TOMÁŠKOVÁ, Vladimír ŠRÁMEK, Martin HELÁN and Jan FRIČ. Polymorphonuclear Cells Show Features of Dysfunctional Activation During Fatal Sepsis. \textit{Frontiers in Immunology}. LAUSANNE: FRONTIERS MEDIA SA, 2021, vol.~12, December 2021, p.~1-12. ISSN~1664-3224. Available from: https://dx.doi.org/10.3389/fimmu.2021.741484.
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