KARAS, Jakub, David VETCHÝ and Jan GAJDZIOK. Práškové částice pro plicní podání (Dry Powder Particles for Pulmonary Application). CHEMICKÉ LISTY. Praha: Czech Society of Chemical Engineering, 2022, vol. 116, No 1, p. 28-34. ISSN 0009-2770. Available from: https://dx.doi.org/10.54779/chl20220028.
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Basic information
Original name Práškové částice pro plicní podání
Name (in English) Dry Powder Particles for Pulmonary Application
Authors KARAS, Jakub (203 Czech Republic, belonging to the institution), David VETCHÝ (203 Czech Republic, belonging to the institution) and Jan GAJDZIOK (203 Czech Republic, guarantor, belonging to the institution).
Edition CHEMICKÉ LISTY, Praha, Czech Society of Chemical Engineering, 2022, 0009-2770.
Other information
Original language Czech
Type of outcome Article in a journal
Field of Study 30104 Pharmacology and pharmacy
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 0.600
RIV identification code RIV/00216224:14160/22:00125336
Organization unit Faculty of Pharmacy
Doi http://dx.doi.org/10.54779/chl20220028
UT WoS 000744052500001
Keywords in English Artificial lungs; Dry powder inhalation; Large porous particles; Lung particle deposition; Particles preparation methods; Spray drying
Tags rivok, ÚFT
Tags International impact, Reviewed
Changed by Changed by: JUDr. Sabina Krejčiříková, učo 383857. Changed: 9/11/2022 15:47.
Abstract
The deposition of a drug to its required destination is crucial for effective lung treatment. It is important to design a suitable formulation that delivers the active ingredient to the desired site and resists the natural cleansing mechanisms of the airways. Large porous particles used as active substance carriers appear to be the most effective option for lung drug delivery. The present article provides a basic overview of the mechanisms of deposition of dry inhalable powders and methods of their preparation and evaluation. Spray drying together with micronization and crystallization techniques are among the most used methods of preparation of the discussed particles. Besides, these techniques can be combined with other production processes (encapsulation, emulsification, etc.). The evaluation of the properties of particles suitable for pulmonary application is based on specific requirements for their density, porosity, shape, aerodynamic parameters, and deposition in the lungs, which can now be simulated on an accurate model of artificial lungs.
Abstract (in English)
The deposition of a drug to its required destination is crucial for effective lung treatment. It is important to design a suitable formulation that delivers the active ingredient to the desired site and resists the natural cleansing mechanisms of the airways. Large porous particles used as active substance carriers appear to be the most effective option for lung drug delivery. The present article provides a basic overview of the mechanisms of deposition of dry inhalable powders and methods of their preparation and evaluation. Spray drying together with micronization and crystallization techniques are among the most used methods of preparation of the discussed particles. Besides, these techniques can be combined with other production processes (encapsulation, emulsification, etc.). The evaluation of the properties of particles suitable for pulmonary application is based on specific requirements for their density, porosity, shape, aerodynamic parameters, and deposition in the lungs, which can now be simulated on an accurate model of artificial lungs.
Links
MUNI/A/1213/2020, interní kód MUName: Formulace a hodnocení depozice mikročásticových systémů k aplikaci do plic. (Acronym: plicní mikročástice)
Investor: Masaryk University
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