Detailed Information on Publication Record
2022
Práškové částice pro plicní podání
KARAS, Jakub, David VETCHÝ and Jan GAJDZIOKBasic information
Original name
Práškové částice pro plicní podání
Name (in English)
Dry Powder Particles for Pulmonary Application
Authors
KARAS, Jakub (203 Czech Republic, belonging to the institution), David VETCHÝ (203 Czech Republic, belonging to the institution) and Jan GAJDZIOK (203 Czech Republic, guarantor, belonging to the institution)
Edition
CHEMICKÉ LISTY, Praha, Czech Society of Chemical Engineering, 2022, 0009-2770
Other information
Language
Czech
Type of outcome
Článek v odborném periodiku
Field of Study
30104 Pharmacology and pharmacy
Country of publisher
Czech Republic
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 0.600
RIV identification code
RIV/00216224:14160/22:00125336
Organization unit
Faculty of Pharmacy
UT WoS
000744052500001
Keywords in English
Artificial lungs; Dry powder inhalation; Large porous particles; Lung particle deposition; Particles preparation methods; Spray drying
Tags
International impact, Reviewed
Změněno: 9/11/2022 15:47, JUDr. Sabina Krejčiříková
V originále
The deposition of a drug to its required destination is crucial for effective lung treatment. It is important to design a suitable formulation that delivers the active ingredient to the desired site and resists the natural cleansing mechanisms of the airways. Large porous particles used as active substance carriers appear to be the most effective option for lung drug delivery. The present article provides a basic overview of the mechanisms of deposition of dry inhalable powders and methods of their preparation and evaluation. Spray drying together with micronization and crystallization techniques are among the most used methods of preparation of the discussed particles. Besides, these techniques can be combined with other production processes (encapsulation, emulsification, etc.). The evaluation of the properties of particles suitable for pulmonary application is based on specific requirements for their density, porosity, shape, aerodynamic parameters, and deposition in the lungs, which can now be simulated on an accurate model of artificial lungs.
In English
The deposition of a drug to its required destination is crucial for effective lung treatment. It is important to design a suitable formulation that delivers the active ingredient to the desired site and resists the natural cleansing mechanisms of the airways. Large porous particles used as active substance carriers appear to be the most effective option for lung drug delivery. The present article provides a basic overview of the mechanisms of deposition of dry inhalable powders and methods of their preparation and evaluation. Spray drying together with micronization and crystallization techniques are among the most used methods of preparation of the discussed particles. Besides, these techniques can be combined with other production processes (encapsulation, emulsification, etc.). The evaluation of the properties of particles suitable for pulmonary application is based on specific requirements for their density, porosity, shape, aerodynamic parameters, and deposition in the lungs, which can now be simulated on an accurate model of artificial lungs.
Links
| MUNI/A/1213/2020, interní kód MU |
|