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@article{1831050, author = {Karas, Jakub and Vetchý, David and Gajdziok, Jan}, article_location = {Praha}, article_number = {1}, doi = {http://dx.doi.org/10.54779/chl20220028}, keywords = {Artificial lungs; Dry powder inhalation; Large porous particles; Lung particle deposition; Particles preparation methods; Spray drying}, language = {cze}, issn = {0009-2770}, journal = {CHEMICKÉ LISTY}, title = {Práškové částice pro plicní podání}, url = {http://chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/3985/3896}, volume = {116}, year = {2022} }
TY - JOUR ID - 1831050 AU - Karas, Jakub - Vetchý, David - Gajdziok, Jan PY - 2022 TI - Práškové částice pro plicní podání JF - CHEMICKÉ LISTY VL - 116 IS - 1 SP - 28-34 EP - 28-34 PB - Czech Society of Chemical Engineering SN - 00092770 KW - Artificial lungs KW - Dry powder inhalation KW - Large porous particles KW - Lung particle deposition KW - Particles preparation methods KW - Spray drying UR - http://chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/3985/3896 N2 - The deposition of a drug to its required destination is crucial for effective lung treatment. It is important to design a suitable formulation that delivers the active ingredient to the desired site and resists the natural cleansing mechanisms of the airways. Large porous particles used as active substance carriers appear to be the most effective option for lung drug delivery. The present article provides a basic overview of the mechanisms of deposition of dry inhalable powders and methods of their preparation and evaluation. Spray drying together with micronization and crystallization techniques are among the most used methods of preparation of the discussed particles. Besides, these techniques can be combined with other production processes (encapsulation, emulsification, etc.). The evaluation of the properties of particles suitable for pulmonary application is based on specific requirements for their density, porosity, shape, aerodynamic parameters, and deposition in the lungs, which can now be simulated on an accurate model of artificial lungs. ER -
KARAS, Jakub, David VETCHÝ and Jan GAJDZIOK. Práškové částice pro plicní podání (Dry Powder Particles for Pulmonary Application). \textit{CHEMICKÉ LISTY}. Praha: Czech Society of Chemical Engineering, 2022, vol.~116, No~1, p.~28-34. ISSN~0009-2770. Available from: https://dx.doi.org/10.54779/chl20220028.
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