KOUKALOVÁ, Renata, Jiří VAŠINA, Jiří ŠTIKA, Michael DOUBEK and Petr SZTURZ. Aggressive systemic mastocytosis with diffuse bone marrow (18) F-FDG uptake. Nuklearmedizin-Nuclear Medicine. Stuttgart: Schattauer GmbH-Verlag Medizin Naturwissenschaften, 2022, vol. 61, No 01, p. 58-61. ISSN 0029-5566. Available from: https://dx.doi.org/10.1055/a-1650-9704.
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Basic information
Original name Aggressive systemic mastocytosis with diffuse bone marrow (18) F-FDG uptake
Authors KOUKALOVÁ, Renata (203 Czech Republic, belonging to the institution), Jiří VAŠINA (203 Czech Republic, belonging to the institution), Jiří ŠTIKA (203 Czech Republic, belonging to the institution), Michael DOUBEK (203 Czech Republic, belonging to the institution) and Petr SZTURZ (203 Czech Republic, guarantor).
Edition Nuklearmedizin-Nuclear Medicine, Stuttgart, Schattauer GmbH-Verlag Medizin Naturwissenschaften, 2022, 0029-5566.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30224 Radiology, nuclear medicine and medical imaging
Country of publisher Germany
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 1.500
RIV identification code RIV/00216224:14110/22:00125372
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1055/a-1650-9704
UT WoS 000715521100001
Keywords in English mastocytosis; positron emission tomography; computed tomography; KIT D816V mutation; osteopenia; osteosclerosis
Tags 14110212, 14110811, podil, rivok
Tags International impact, Reviewed
Changed by Changed by: Mgr. Tereza Miškechová, učo 341652. Changed: 19/2/2024 11:10.
Abstract
Mastocytosis is a clonal hematopoietic disorder characterized by proliferation of abnormal mast cells in various organs including the skin, digestive system, lymph nodes, and bone marrow. We report on a 75-year-old woman presenting with abdominal pain, vomiting, diarrhoea, myalgia, and weight loss. Abdominal CT showed hepatosplenomegaly with heterogeneous splenic parenchyma, lymphadenopathy, and osteopenia with areas of osteosclerosis but no primary tumour. An 18F-FDG PET/CT revealed an overall low metabolic activity of the lesions with a diffuse bone marrow involvement raising suspicion of a haematological neoplasm. Subsequently, bone marrow and peripheral blood examinations confirmed the diagnosis of aggressive systemic mastocytosis.
PrintDisplayed: 19/7/2024 22:19