Podrobný výpis o publikaci

BISWAS, A., S. MONDAL, S. K. DAS, A. BOSE, S. THOMAS, K. GHOSAL, S. ROY a Ivo PROVAZNÍK. Development and Characterization of Natural Product Derived Macromolecules Based Interpenetrating Polymer Network for Therapeutic Drug Targeting. ACS Omega. WASHINGTON: American Chemical Society, 2021, roč. 6, č. 43, s. 28699-28709. ISSN 2470-1343. Dostupné z: https://dx.doi.org/10.1021/acsomega.1c03363.

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TY  - JOUR
ID  - 1834409
AU  - Biswas, A. - Mondal, S. - Das, S. K. - Bose, A. - Thomas, S. - Ghosal, K. - Roy, S. - Provazník, Ivo
PY  - 2021
TI  - Development and Characterization of Natural Product Derived Macromolecules Based Interpenetrating Polymer Network for Therapeutic Drug Targeting
JF  - ACS Omega
VL  - 6
IS  - 43
SP  - 28699-28709
EP  - 28699-28709
PB  - American Chemical Society
SN  - 24701343
KW  - MULTIPARTICULATE FORMULATION APPROACHIN-VITROCONTROLLED-RELEASEDICLOFENAC SODIUMHYDROGEL BEADSCARBOXYMETHYL XANTHANSUSTAINED-RELEASEORAL DELIVERYGEL BEADSALGINATE
UR  - https://pubs.acs.org/doi/10.1021/acsomega.1c03363
N2  - Interpenetrating polymer network (IPN)-based bead formulations were exploited by cross-linking different hydrophilic polymers in different combinations and at different ratios. Polyvinyl alcohol, xanthan gum, guar gum, gellan gum, and sodium alginate (Na-alginate) were used in this work as hydrophilic polymers to enhance the solubility of diclofenac sodium and also to target the delivery at preferred locations. IPN beads based on polysaccharides were prepared by the ionic gelation method. Differential scanning calorimetry, powder X-ray diffraction, scanning electron microscopy, and Fourier transform infrared spectroscopy data showed that the IPN microbeads solubilized and encapsulated the drug within the network. We found over 83% encapsulation efficiency of the drug delivery system for the drug, and this efficiency increased with the concentration of the polymer. Ex vivo experiments using the goat intestine revealed that the IPN microbeads were able to adhere to the intestinal epithelium, a mucoadhesive behavior that could be beneficial to the drug pharmacokinetics, while in vitro experiments in phosphate buffer showed that the IPN enabled significant drug release. We believe that these IPN microbeads are an excellent drug delivery system to solubilize drug molecules and ensure adhesion to the intestinal wall, thereby localizing the drug release to enhance bioavailability of poorly soluble drugs.
ER  -

Základní údaje
Originální název	Development and Characterization of Natural Product Derived Macromolecules Based Interpenetrating Polymer Network for Therapeutic Drug Targeting
Autoři	BISWAS, A., S. MONDAL, S. K. DAS, A. BOSE, S. THOMAS, K. GHOSAL, S. ROY a Ivo PROVAZNÍK (203 Česká republika, garant, domácí).
Vydání	ACS Omega, WASHINGTON, American Chemical Society, 2021, 2470-1343.

Další údaje
Originální jazyk	angličtina
Typ výsledku	Článek v odborném periodiku
Obor	30104 Pharmacology and pharmacy
Stát vydavatele	Spojené státy
Utajení	není předmětem státního či obchodního tajemství
WWW	URL
Impakt faktor	Impact factor: 4.132
Kód RIV	RIV/00216224:14110/21:00124164
Organizační jednotka	Lékařská fakulta
Doi	http://dx.doi.org/10.1021/acsomega.1c03363
UT WoS	000714105800025
Klíčová slova anglicky	MULTIPARTICULATE FORMULATION APPROACHIN-VITROCONTROLLED-RELEASEDICLOFENAC SODIUMHYDROGEL BEADSCARBOXYMETHYL XANTHANSUSTAINED-RELEASEORAL DELIVERYGEL BEADSALGINATE
Štítky	14110515, rivok
Příznaky	Mezinárodní význam, Recenzováno
Změnil	Změnila: Mgr. Tereza Miškechová, učo 341652. Změněno: 15. 2. 2022 13:32.

Anotace
Interpenetrating polymer network (IPN)-based bead formulations were exploited by cross-linking different hydrophilic polymers in different combinations and at different ratios. Polyvinyl alcohol, xanthan gum, guar gum, gellan gum, and sodium alginate (Na-alginate) were used in this work as hydrophilic polymers to enhance the solubility of diclofenac sodium and also to target the delivery at preferred locations. IPN beads based on polysaccharides were prepared by the ionic gelation method. Differential scanning calorimetry, powder X-ray diffraction, scanning electron microscopy, and Fourier transform infrared spectroscopy data showed that the IPN microbeads solubilized and encapsulated the drug within the network. We found over 83% encapsulation efficiency of the drug delivery system for the drug, and this efficiency increased with the concentration of the polymer. Ex vivo experiments using the goat intestine revealed that the IPN microbeads were able to adhere to the intestinal epithelium, a mucoadhesive behavior that could be beneficial to the drug pharmacokinetics, while in vitro experiments in phosphate buffer showed that the IPN enabled significant drug release. We believe that these IPN microbeads are an excellent drug delivery system to solubilize drug molecules and ensure adhesion to the intestinal wall, thereby localizing the drug release to enhance bioavailability of poorly soluble drugs.

Anotace

Interpenetrating polymer network (IPN)-based bead formulations were exploited by cross-linking different hydrophilic polymers in different combinations and at different ratios. Polyvinyl alcohol, xanthan gum, guar gum, gellan gum, and sodium alginate (Na-alginate) were used in this work as hydrophilic polymers to enhance the solubility of diclofenac sodium and also to target the delivery at preferred locations. IPN beads based on polysaccharides were prepared by the ionic gelation method. Differential scanning calorimetry, powder X-ray diffraction, scanning electron microscopy, and Fourier transform infrared spectroscopy data showed that the IPN microbeads solubilized and encapsulated the drug within the network. We found over 83% encapsulation efficiency of the drug delivery system for the drug, and this efficiency increased with the concentration of the polymer. Ex vivo experiments using the goat intestine revealed that the IPN microbeads were able to adhere to the intestinal epithelium, a mucoadhesive behavior that could be beneficial to the drug pharmacokinetics, while in vitro experiments in phosphate buffer showed that the IPN enabled significant drug release. We believe that these IPN microbeads are an excellent drug delivery system to solubilize drug molecules and ensure adhesion to the intestinal wall, thereby localizing the drug release to enhance bioavailability of poorly soluble drugs.