J 2022

Variability assessment of manual segmentations of ischemic lesion volume on 24-h non-contrast CT

CIMFLOVÁ, Petra, J. M. OSPEL, M. MARKO, B. K. MENON, W. QIU et. al.

Basic information

Original name

Variability assessment of manual segmentations of ischemic lesion volume on 24-h non-contrast CT

Authors

CIMFLOVÁ, Petra (203 Czech Republic, belonging to the institution), J. M. OSPEL, M. MARKO, B. K. MENON and W. QIU (guarantor)

Edition

NEURORADIOLOGY, NEW YORK, SPRINGER, 2022, 0028-3940

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30224 Radiology, nuclear medicine and medical imaging

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 2.800

RIV identification code

RIV/00216224:14110/22:00125374

Organization unit

Faculty of Medicine

DOI

UT WoS

000721656300003

Keywords in English

Ischemic stroke; Ischemic lesion volume; Non-contrast CT

Tags

Tags

International impact, Reviewed
Změněno: 20/7/2022 09:33, Mgr. Tereza Miškechová

Abstract

V originále

Purpose Infarct lesion volume (ILV) may serve as an imaging biomarker for clinical outcomes in the early post-treatment stage in patients with acute ischemic stroke. The aim of this study was to evaluate the inter- and intra-rater reliability of manual segmentation of ILV on follow-up non-contrast CT (NCCT) scans. Methods Fifty patients from the Prove-IT study were randomly selected for this analysis. Three raters manually segmented ILV on 24-h NCCT scans, slice by slice, three times. The reference standard for ILV was generated by the Simultaneous Truth And Performance Level estimation (STAPLE) algorithm. Intra- and inter-rater reliability was evaluated, using metrics of intraclass correlation coefficient (ICC) regarding lesion volume and the Dice similarity coefficient (DSC). Results Median age of the 50 subjects included was 74.5 years (interquartile range [IQR] 67-80), 54% were women, median baseline National Institutes of Health Stroke Scale was 18 (IQR 11-22), median baseline ASPECTS was 9 (IQR 6-10). The mean reference standard ILV was 92.5 ml (standard deviation (SD) +/- 100.9 ml). The manually segmented ILV ranged from 88.2 +/- 91.5 to 135.5 +/- 119.9 ml (means referring to the variation between readers, SD within readers). Inter-rater ICC was 0.83 (95%CI: 0.76-0.88); intra-rater ICC ranged from 0.85 (95%CI: 0.72-0.92) to 0.95 (95%CI: 0.91-0.97). The mean DSC among the three readers ranged from 65.5 +/- 22.9 to 76.4 +/- 17.1% and the mean overall DSC was 72.8 +/- 23.0%. Conclusion Manual ILV measurements on follow-up CT scans are reliable to measure the radiological outcome despite some variability.