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@article{1834640,
author = {Vymazal, Ondřej and Kýrová, Kamila and De Zuani, Marco and Vlková, Marcela and Hortová Kohoutková, Marcela and Frič, Jan},
article_location = {LAUSANNE},
article_number = {November 2021},
doi = {http://dx.doi.org/10.3389/fimmu.2021.770515},
keywords = {immunosuppression; calcineurin inbibitors; neutrophil (PMN) function; sepsis; NFAT signaling; pattern recognition receptor (PRR)},
language = {eng},
issn = {1664-3224},
journal = {Frontiers in Immunology},
title = {Immunosuppression Affects Neutrophil Functions: Does Calcineurin-NFAT Signaling Matter?},
url = {https://www.frontiersin.org/articles/10.3389/fimmu.2021.770515/full},
volume = {12},
year = {2021}
}
TY - JOUR
ID - 1834640
AU - Vymazal, Ondřej - Kýrová, Kamila - De Zuani, Marco - Vlková, Marcela - Hortová Kohoutková, Marcela - Frič, Jan
PY - 2021
TI - Immunosuppression Affects Neutrophil Functions: Does Calcineurin-NFAT Signaling Matter?
JF - Frontiers in Immunology
VL - 12
IS - November 2021
SP - 1-9
EP - 1-9
PB - FRONTIERS MEDIA SA
SN - 16643224
KW - immunosuppression
KW - calcineurin inbibitors
KW - neutrophil (PMN) function
KW - sepsis
KW - NFAT signaling
KW - pattern recognition receptor (PRR)
UR - https://www.frontiersin.org/articles/10.3389/fimmu.2021.770515/full
N2 - Neutrophils are innate immune cells with important roles in antimicrobial defense. However, impaired or dysregulated neutrophil function can result in host tissue damage, loss of homeostasis, hyperinflammation or pathological immunosuppression. A central link between neutrophil activation and immune outcomes is emerging to be the calcineurin-nuclear factor of activated T cells (NFAT) signaling pathway, which is activated by neutrophil detection of a microbial threat via pattern recognition receptors and results in inflammatory cytokine production. This potent pro-inflammatory pathway is also the target of several immunosuppressive drugs used for the treatment of autoimmune disorders, during solid organ and hematopoietic cell transplantations, and as a part of anti-cancer therapy: but what effects these drugs have on neutrophil function, and their broader consequences for immune homeostasis and microbial defense are not yet known. Here, we bring together the emerging literature describing pathology- and drug- induced neutrophil impairment, with particular focus on their effects on calcineurin-NFAT signaling in the innate immune compartment.
ER -
VYMAZAL, Ondřej, Kamila KÝROVÁ, Marco DE ZUANI, Marcela VLKOVÁ, Marcela HORTOVÁ KOHOUTKOVÁ and Jan FRIČ. Immunosuppression Affects Neutrophil Functions: Does Calcineurin-NFAT Signaling Matter? \textit{Frontiers in Immunology}. LAUSANNE: FRONTIERS MEDIA SA, 2021, vol.~12, November 2021, p.~1-9. ISSN~1664-3224. Available from: https://dx.doi.org/10.3389/fimmu.2021.770515.
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