Immunosuppression Affects Neutrophil Functions: Does
Calcineurin-NFAT Signaling Matter?

J 2021

Immunosuppression Affects Neutrophil Functions: Does Calcineurin-NFAT Signaling Matter?

VYMAZAL, Ondřej, Kamila KÝROVÁ, Marco DE ZUANI, Marcela VLKOVÁ, Marcela HORTOVÁ KOHOUTKOVÁ et. al.

Basic information

Original name

Immunosuppression Affects Neutrophil Functions: Does Calcineurin-NFAT Signaling Matter?

Authors

VYMAZAL, Ondřej (203 Czech Republic, belonging to the institution), Kamila KÝROVÁ (203 Czech Republic), Marco DE ZUANI, Marcela VLKOVÁ (203 Czech Republic, belonging to the institution), Marcela HORTOVÁ KOHOUTKOVÁ (203 Czech Republic) and Jan FRIČ (203 Czech Republic)

Edition

Frontiers in Immunology, LAUSANNE, FRONTIERS MEDIA SA, 2021, 1664-3224

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30102 Immunology

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 8.786

RIV identification code

RIV/00216224:14110/21:00120227

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.3389/fimmu.2021.770515

UT WoS

000719673100001

Keywords in English

immunosuppression; calcineurin inbibitors; neutrophil (PMN) function; sepsis; NFAT signaling; pattern recognition receptor (PRR)

Abstract

V originále

Neutrophils are innate immune cells with important roles in antimicrobial defense. However, impaired or dysregulated neutrophil function can result in host tissue damage, loss of homeostasis, hyperinflammation or pathological immunosuppression. A central link between neutrophil activation and immune outcomes is emerging to be the calcineurin-nuclear factor of activated T cells (NFAT) signaling pathway, which is activated by neutrophil detection of a microbial threat via pattern recognition receptors and results in inflammatory cytokine production. This potent pro-inflammatory pathway is also the target of several immunosuppressive drugs used for the treatment of autoimmune disorders, during solid organ and hematopoietic cell transplantations, and as a part of anti-cancer therapy: but what effects these drugs have on neutrophil function, and their broader consequences for immune homeostasis and microbial defense are not yet known. Here, we bring together the emerging literature describing pathology- and drug- induced neutrophil impairment, with particular focus on their effects on calcineurin-NFAT signaling in the innate immune compartment.

Links

NU21-06-00408, research and development project

Name: Prediktivní potenciál dynamických změn v subpopulacích neutrofilů a monocytů ve vývoji SIRS a sepse po operaci nebo traumatu.

Investor: Ministry of Health of the CR, Subprogram 1 - standard

Citovat

VYMAZAL, Ondřej, Kamila KÝROVÁ, Marco DE ZUANI, Marcela VLKOVÁ, Marcela HORTOVÁ KOHOUTKOVÁ and Jan FRIČ. Immunosuppression Affects Neutrophil Functions: Does Calcineurin-NFAT Signaling Matter? Frontiers in Immunology. LAUSANNE: FRONTIERS MEDIA SA, 2021, vol. 12, November 2021, p. 1-9. ISSN 1664-3224. Available from: https://dx.doi.org/10.3389/fimmu.2021.770515.

@article{1834640,
   author = {Vymazal, Ondřej and Kýrová, Kamila and De Zuani, Marco and Vlková, Marcela and Hortová Kohoutková, Marcela and Frič, Jan},
   article_location = {LAUSANNE},
   article_number = {November 2021},
   doi = {http://dx.doi.org/10.3389/fimmu.2021.770515},
   keywords = {immunosuppression; calcineurin inbibitors; neutrophil (PMN) function; sepsis; NFAT signaling; pattern recognition receptor (PRR)},
   language = {eng},
   issn = {1664-3224},
   journal = {Frontiers in Immunology},
   title = {Immunosuppression Affects Neutrophil Functions: Does Calcineurin-NFAT Signaling Matter?},
   url = {https://www.frontiersin.org/articles/10.3389/fimmu.2021.770515/full},
   volume = {12},
   year = {2021}
}

TY  - JOUR
ID  - 1834640
AU  - Vymazal, Ondřej - Kýrová, Kamila - De Zuani, Marco - Vlková, Marcela - Hortová Kohoutková, Marcela - Frič, Jan
PY  - 2021
TI  - Immunosuppression Affects Neutrophil Functions: Does Calcineurin-NFAT Signaling Matter?
JF  - Frontiers in Immunology
VL  - 12
IS  - November 2021
SP  - 1-9
EP  - 1-9
PB  - FRONTIERS MEDIA SA
SN  - 16643224
KW  - immunosuppression
KW  - calcineurin inbibitors
KW  - neutrophil (PMN) function
KW  - sepsis
KW  - NFAT signaling
KW  - pattern recognition receptor (PRR)
UR  - https://www.frontiersin.org/articles/10.3389/fimmu.2021.770515/full
N2  - Neutrophils are innate immune cells with important roles in antimicrobial defense. However, impaired or dysregulated neutrophil function can result in host tissue damage, loss of homeostasis, hyperinflammation or pathological immunosuppression. A central link between neutrophil activation and immune outcomes is emerging to be the calcineurin-nuclear factor of activated T cells (NFAT) signaling pathway, which is activated by neutrophil detection of a microbial threat via pattern recognition receptors and results in inflammatory cytokine production. This potent pro-inflammatory pathway is also the target of several immunosuppressive drugs used for the treatment of autoimmune disorders, during solid organ and hematopoietic cell transplantations, and as a part of anti-cancer therapy: but what effects these drugs have on neutrophil function, and their broader consequences for immune homeostasis and microbial defense are not yet known. Here, we bring together the emerging literature describing pathology- and drug- induced neutrophil impairment, with particular focus on their effects on calcineurin-NFAT signaling in the innate immune compartment.
ER  -

VYMAZAL, Ondřej, Kamila KÝROVÁ, Marco DE ZUANI, Marcela VLKOVÁ, Marcela HORTOVÁ KOHOUTKOVÁ and Jan FRIČ. Immunosuppression Affects Neutrophil Functions: Does Calcineurin-NFAT Signaling Matter? \textit{Frontiers in Immunology}. LAUSANNE: FRONTIERS MEDIA SA, 2021, vol.~12, November 2021, p.~1-9. ISSN~1664-3224. Available from: https://dx.doi.org/10.3389/fimmu.2021.770515.

Detailed Information on Publication Record