J 2021

Correlation between vitamin D serum levels and severity of diabetic retinopathy in patients with type 2 diabetes mellitus

NADRI, G., S. SAXENA, A. KAUR, K. AHMAD, P. GARG et. al.

Basic information

Original name

Correlation between vitamin D serum levels and severity of diabetic retinopathy in patients with type 2 diabetes mellitus

Authors

NADRI, G., S. SAXENA, A. KAUR, K. AHMAD, P. GARG, A. A. MAHDI, L. AKDUMAN, K. GAZDIKOVA, M. CAPRNDA, P. VESELY, Peter KRUŽLIAK (703 Slovakia, guarantor, belonging to the institution) and V. KRASNIK

Edition

JOURNAL OF ENDOCRINOLOGY METABOLISM AND DIABETES OF SOUTH AFRICA, ABINGDON, ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD, 2021, 1608-9677

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30202 Endocrinology and metabolism

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

RIV identification code

RIV/00216224:14110/21:00124187

Organization unit

Faculty of Medicine

DOI

UT WoS

000694947100002

Keywords in English

Diabetic retinopathy (DR); disorganization of retinal inner layer (DRIL); spectral domain optical coherence tomography (SD-OCT); vitamin D

Tags

Tags

International impact, Reviewed
Změněno: 16/2/2022 12:51, Mgr. Tereza Miškechová

Abstract

V originále

Purpose: To study the correlation of serum vitamin D levels with quantitative (central subfield thickness [CST], cube average thickness [CAT]), cross-sectional (disorganisation of retinal inner layer [DRIL] and ellipsoid zone [EZ]) and topographic parameters (retinal pigment epithelium [RPE]) on spectral domain optical coherence tomography (SD-OCT) in diabetic retinopathy (DR), for the first time. Methods: Eighty-eight consecutive cases of type 2 diabetes mellitus with no retinopathy (No DR; n = 22); non-proliferative DR (NPDR; n = 22); proliferative DR (PDR; n = 22) and healthy controls (n = 22) were included, after sample size calculation. On SDOCT, physician-friendly grading systems were created for DRIL, EZ disruption and RPE alterations. Serum vitamin D was analysed using a standard protocol. Statistical analysis was done using Pearson correlation, Student's t-test, ANOVA, Newman-Keuls test, chi-square test and univariate ordinal logistic regression analysis. Results: Mean serum vitamin D levels (ng/ml) were: No DR = 23.36 +/- 2.00, NPDR = 17.88 +/- 1.86, PDR = 14.07 +/- 1.21, and controls = 25.11 +/- 1.59. Low vitamin D levels correlated significantly with severity of retinopathy, VA (r = 0.50), CST (r = 0.36), CAT (r = 0.41), DRIL (r = 0.35), EZ disruption (r =0.40) and RPE alterations (r=0.37), respectively (p <0.01). Significantly low vitamin D levels were observed in subjects with DRIL present versus DRIL absent; EZ disruption, focal versus global versus intact; RPE alterations, focal versus global versus none, respectively (p < 0.05). Conclusions: Low serum vitamin D levels correlate with the presence of DRIL, EZ disruption and RPE alterations and increased severity of DR.