Lung Cancer Versus "Young Cancer": Is Non-Small Cell Lung Cancer in Young Patients a Different ...
| BRATOVÁ, Monika, Kristián BRAT, Karolina HURDALKOVA, Magda BARINOVA, Marie DROSSLEROVA, Juraj KULTAN, Matyas WANKE, Leona KOUBKOVA, Jana KREJCI and Martin SVATON. Lung Cancer Versus "Young Cancer": Is Non-Small Cell Lung Cancer in Young Patients a Different Entity? JOURNAL OF ADOLESCENT AND YOUNG ADULT ONCOLOGY. NEW ROCHELLE: MARY ANN LIEBERT, INC, 2022, vol. 11, No 5, p. 451-458. ISSN 2156-5333. Available from: https://dx.doi.org/10.1089/jayao.2021.0069. |
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| Basic information | |
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| Original name | Lung Cancer Versus "Young Cancer": Is Non-Small Cell Lung Cancer in Young Patients a Different Entity? |
| Authors | BRATOVÁ, Monika (203 Czech Republic, belonging to the institution), Kristián BRAT (703 Slovakia, guarantor, belonging to the institution), Karolina HURDALKOVA (203 Czech Republic), Magda BARINOVA (203 Czech Republic), Marie DROSSLEROVA (203 Czech Republic), Juraj KULTAN, Matyas WANKE (203 Czech Republic), Leona KOUBKOVA (203 Czech Republic), Jana KREJCI (203 Czech Republic) and Martin SVATON (203 Czech Republic). |
| Edition | JOURNAL OF ADOLESCENT AND YOUNG ADULT ONCOLOGY, NEW ROCHELLE, MARY ANN LIEBERT, INC, 2022, 2156-5333. |
| Other information | |
|---|---|
| Original language | English |
| Type of outcome | Article in a journal |
| Field of Study | 30204 Oncology |
| Country of publisher | United States of America |
| Confidentiality degree | is not subject to a state or trade secret |
| WWW | URL |
| Impact factor | Impact factor: 2.000 |
| RIV identification code | RIV/00216224:14110/22:00125388 |
| Organization unit | Faculty of Medicine |
| Doi | http://dx.doi.org/10.1089/jayao.2021.0069 |
| UT WoS | 000715838900001 |
| Keywords in English | non-small cell lung cancer; young patients; younger than the age of 40 years; overall survival; prognosis; mutations |
| Tags | 14110215, rivok |
| Tags | International impact, Reviewed |
| Changed by | Changed by: Mgr. Tereza Miškechová, učo 341652. Changed: 24/2/2023 09:52. |
| Abstract |
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| Purpose: Aim was to analyze demographic and tumor characteristics, treatment, and survival of patients with lung cancer younger than 40 years of age (U40) compared to older subgroups (41-70 and >70 years). Methods: We analyzed data of young patients diagnosed and treated in 2011-2019 in five pneumo-oncology centers in Czechia. Standard descriptive statistics, chi-squared test, Fisher exact test, and Kaplan-Meier survival analysis were used. p-Values <0.05 were considered significant. These data were compared with two control subgroups (cohort 1: 41-70 years, cohort 2: >70 years). Results: We identified 66 patients U40, 61 with non-small cell lung cancer (NSCLC)-50.8% men, mean age 34.6 years, 54.1% nonsmokers, daily good performance status, and 82% in stage IV. Adenocarcinomas dominated, endothelial growth factor receptor (EGFR) positivity was less common than in older groups contrary to anaplastic lymphoma kinase (ALK) mutations. Median progression-free survival was 3.7 months (vs. 4.9 and 6.2 months; p = 0.006) and overall survival reached 11.7 months (vs. 22.3 and 27.3 months; p < 0.001). Young patients in stage IV and never-smokers had shorter survival than older patients. Conclusion: Patients with NSCLC U40 had significantly worse prognosis than older patients.
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