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@article{1834768,
author = {Pink, Richard and Michalek, Jaroslav and Kral, David and Mozola, Michal and Benes, Pavel and Lenka, Saskova and Dvořák, Zdeněk},
article_location = {Olomouc},
article_number = {2},
doi = {http://dx.doi.org/10.5507/bp.2021.062},
keywords = {oral squamous cell carcinoma of head and neck; neoplasm invasiveness; head and neck neoplasms; maxillofacial surgery; tumor grading; neoplasm staging; histocytochemistry},
language = {eng},
issn = {1213-8118},
journal = {Biomedical Papers, Olomouc: Palacky University},
title = {Importance of evaluation of bone invasion type in squamous cell carcinomas of the oral cavity and oropharynx},
url = {https://biomed.papers.upol.cz/corproof.php?tartkey=bio-000000-3084},
volume = {167},
year = {2023}
}
TY - JOUR
ID - 1834768
AU - Pink, Richard - Michalek, Jaroslav - Kral, David - Mozola, Michal - Benes, Pavel - Lenka, Saskova - Dvořák, Zdeněk
PY - 2023
TI - Importance of evaluation of bone invasion type in squamous cell carcinomas of the oral cavity and oropharynx
JF - Biomedical Papers, Olomouc: Palacky University
VL - 167
IS - 2
SP - 139-144
EP - 139-144
PB - Palacky University
SN - 12138118
KW - oral squamous cell carcinoma of head and neck
KW - neoplasm invasiveness
KW - head and neck neoplasms
KW - maxillofacial surgery
KW - tumor grading
KW - neoplasm staging
KW - histocytochemistry
UR - https://biomed.papers.upol.cz/corproof.php?tartkey=bio-000000-3084
N2 - Aims. The objective of this study was to compare bone invasion type with histopathological, clinical and immunohis Methods. The study included 49 patients who were treated for oral squamous cell carcinoma. Of which, 30 patients, with presence of bone invasion on histopathology, were divided according to the type of bone invasion (erosive, infiltrative, mixed). Each invasion type was compared to microvascular density using the CD34 marker. Results. The bone invasion was observed in 30 out of 49 patients (61.22%). On McNemar's test, statistically significant association was observed between bone invasion types and histopathological grade. In contrast, no significant correlation was observed between bone invasion type, and tumour volume or nodal metastases. In tumours with bone invasion of the infiltrative type, higher frequency of locoregional relapses was observed. The 5-year survival, since diagnosis, was approximately 60% in the erosive group, 40% in the mixed group, and merely 15% in the infiltrative group. Conclusion. Peritumoural microvascular density was not significantly related to bone invasion types. Whereas, a significantly higher intratumoural microvascular density was observed in infiltrative type of the bone invasion, when compared to the erosive and mixed type.
ER -
PINK, Richard, Jaroslav MICHALEK, David KRAL, Michal MOZOLA, Pavel BENES, Saskova LENKA and Zdeněk DVOŘÁK. Importance of evaluation of bone invasion type in squamous cell carcinomas of the oral cavity and oropharynx. \textit{Biomedical Papers, Olomouc: Palacky University}. Olomouc: Palacky University, 2023, vol.~167, No~2, p.~139-144. ISSN~1213-8118. Available from: https://dx.doi.org/10.5507/bp.2021.062.
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