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@article{1834977,
author = {Danhofer, Pavlína and Horák, Ondřej and Knedlíková, Lenka and Kolář, Senad and Jičínská, AnnaandMarie and Jabandžiev, Petr and Ošlejšková, Hana},
article_location = {Prague},
article_number = {2},
doi = {http://dx.doi.org/10.48095/cccsnn2021127},
keywords = {autism; autism spectrum disorders; probiotics; gut microbiota; fecal transplantation},
language = {eng},
issn = {1210-7859},
journal = {Ceska a slovenska neurologie a neurochirurgie},
title = {Gut microbiota and autism spectrum disorders},
url = {https://www.csnn.eu/en/journals/czech-and-slovak-neurology-and-neurosurgery/2021-2-7/gut-microbiota-and-autism-spectrum-disorders-127024},
volume = {84},
year = {2021}
}
TY - JOUR
ID - 1834977
AU - Danhofer, Pavlína - Horák, Ondřej - Knedlíková, Lenka - Kolář, Senad - Jičínská, Anna-Marie - Jabandžiev, Petr - Ošlejšková, Hana
PY - 2021
TI - Gut microbiota and autism spectrum disorders
JF - Ceska a slovenska neurologie a neurochirurgie
VL - 84
IS - 2
SP - 127-134
EP - 127-134
PB - CZECH MEDICAL SOC
SN - 12107859
KW - autism
KW - autism spectrum disorders
KW - probiotics
KW - gut microbiota
KW - fecal transplantation
UR - https://www.csnn.eu/en/journals/czech-and-slovak-neurology-and-neurosurgery/2021-2-7/gut-microbiota-and-autism-spectrum-disorders-127024
N2 - Autism spectrum disorders (ASD) are neurodevelopmental and neuropsychiatric disorders with clinical manifestation in childhood, characterized by difficulties in social interaction and communication, limited interests, and repetitive behavior. In recent years, there has been a signifi cant increase in the prevalence of this disorder, currently aff ecting 1-2% of children. In pathophysiology, genetic factors are mainly used, which are also modified in their phenotypic expression by environmental factors. A large percentage of patients with ASD also have a variety of gastrointestinal problems; children experience constipation or diarrhea, flatulence, or nonspecific abdominal pain. In last years, the connection of intestinal symptomatology with the manifestations of ASD has come to the forefront of scientific interest with the development of new molecular-bio logical methods of studying the community of intestinal microorganisms, the gut microbio ta. Communication between the gut and the CNS (the gut-brain axis) is made possible by a very complex two-way neurohumoral communication system. This system ensures the effect of the intestinal microbio ta on brain functions and allows the brain signals to affect the intestinal microbio ta activity and the gastrointestinal tract functions. This article focuses on various pathophysiological mechanisms involved in these processes and discusses in detail the possible therapeutic modalities that affect the gut microbio ta composition and function, such as the use of vancomycin, oxytocin, prebio tics and probio tics, as well as fecal transplantation, which has very promising results in relation to both gastrointestinal and ASD symptoms.
ER -
DANHOFER, Pavlína, Ondřej HORÁK, Lenka KNEDLÍKOVÁ, Senad KOLÁŘ, Anna-Marie JIČÍNSKÁ, Petr JABANDŽIEV and Hana OŠLEJŠKOVÁ. Gut microbiota and autism spectrum disorders. \textit{Ceska a slovenska neurologie a neurochirurgie}. Prague: CZECH MEDICAL SOC, 2021, vol.~84, No~2, p.~127-134. ISSN~1210-7859. Available from: https://dx.doi.org/10.48095/cccsnn2021127.
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