| VRBSKY, Jan, Vladimir VINARSKY, Ana Rubina PERESTRELO, Jorge Oliver DE LA CRUZ, Fabiana MARTINO, Antonio POMPEIANO, Valerio IZZI, Ota HLINOMAZ, Vladimír ROTREKL, Marius SUDOL, Stefania PAGLIARI and Giancarlo FORTE. Evidence for discrete modes of YAP1 signaling via mRNA splice isoforms in development and diseases. Genomics. United States: Elsevier Science Inc, 2021, vol. 113, No 3, p. 1349-1365. ISSN 0888-7543. Available from: https://dx.doi.org/10.1016/j.ygeno.2021.03.009. |
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@article{1834998,
author = {Vrbsky, Jan and Vinarsky, Vladimir and Perestrelo, Ana Rubina and De la Cruz, Jorge Oliver and Martino, Fabiana and Pompeiano, Antonio and Izzi, Valerio and Hlinomaz, Ota and Rotrekl, Vladimír and Sudol, Marius and Pagliari, Stefania and Forte, Giancarlo},
article_location = {United States},
article_number = {3},
doi = {http://dx.doi.org/10.1016/j.ygeno.2021.03.009},
keywords = {YAP1 isoforms; Alternative splicing; Tissue-specific expression; Cardiac differentiation},
language = {eng},
issn = {0888-7543},
journal = {Genomics},
title = {Evidence for discrete modes of YAP1 signaling via mRNA splice isoforms in development and diseases},
url = {https://www.sciencedirect.com/science/article/pii/S0888754321001014?via%3Dihub},
volume = {113},
year = {2021}
}
TY - JOUR
ID - 1834998
AU - Vrbsky, Jan - Vinarsky, Vladimir - Perestrelo, Ana Rubina - De la Cruz, Jorge Oliver - Martino, Fabiana - Pompeiano, Antonio - Izzi, Valerio - Hlinomaz, Ota - Rotrekl, Vladimír - Sudol, Marius - Pagliari, Stefania - Forte, Giancarlo
PY - 2021
TI - Evidence for discrete modes of YAP1 signaling via mRNA splice isoforms in development and diseases
JF - Genomics
VL - 113
IS - 3
SP - 1349-1365
EP - 1349-1365
PB - Elsevier Science Inc
SN - 08887543
KW - YAP1 isoforms
KW - Alternative splicing
KW - Tissue-specific expression
KW - Cardiac differentiation
UR - https://www.sciencedirect.com/science/article/pii/S0888754321001014?via%3Dihub
N2 - Yes-associated protein 1 (YAP1) is a transcriptional co-activator downstream of Hippo pathway. The pathway exerts crucial roles in organogenesis and its dysregulation is associated with the spreading of different cancer types. YAP1 gene encodes for multiple protein isoforms, whose specific functions are not well defined. We demonstrate the splicing of isoform-specific mRNAs is controlled in a stage- and tissue-specific fashion. We designed expression vectors encoding for the most-represented isoforms of YAP1 with either one or two WW domains and studied their specific signaling activities in YAP1 knock-out cell lines. YAP1 isoforms display both common and unique functions and activate distinct transcriptional programs, as the result of their unique protein interactomes. By generating TEAD-based transcriptional reporter cell lines, we demonstrate individual YAP1 isoforms display unique effects on cell proliferation and differentiation. Finally, we illustrate the complexity of the regulation of Hippo-YAP1 effector in physiological and in pathological conditions of the heart.
ER -
VRBSKY, Jan, Vladimir VINARSKY, Ana Rubina PERESTRELO, Jorge Oliver DE LA CRUZ, Fabiana MARTINO, Antonio POMPEIANO, Valerio IZZI, Ota HLINOMAZ, Vladimír ROTREKL, Marius SUDOL, Stefania PAGLIARI and Giancarlo FORTE. Evidence for discrete modes of YAP1 signaling via mRNA splice isoforms in development and diseases. \textit{Genomics}. United States: Elsevier Science Inc, 2021, vol.~113, No~3, p.~1349-1365. ISSN~0888-7543. Available from: https://dx.doi.org/10.1016/j.ygeno.2021.03.009.
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