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@article{1835078,
author = {Barák, Martin and Fedorová, Veronika and Pospíšilová, Veronika and Raška, Jan and Vochyánová, Simona and Sedmík, Jiří and Hříbková, Hana and Klímová, Hana and Váňová, Tereza and Bohačiaková, Dáša},
article_location = {NEW YORK},
article_number = {2},
doi = {http://dx.doi.org/10.1007/s12015-021-10254-3},
keywords = {iPSCs; Neural differentiation; Alzheimer’s disease; In vitro differentiation; Neural stem cells; Neural progenitors; Neurons; Astrocytes; Microglia; Cerebral organoids},
language = {eng},
issn = {2629-3269},
journal = {Stem Cell Reviews and Reports},
title = {Human iPSC-Derived Neural Models for Studying Alzheimer’s Disease: from Neural Stem Cells to Cerebral Organoids},
url = {https://link.springer.com/article/10.1007/s12015-021-10254-3},
volume = {18},
year = {2022}
}
TY - JOUR
ID - 1835078
AU - Barák, Martin - Fedorová, Veronika - Pospíšilová, Veronika - Raška, Jan - Vochyánová, Simona - Sedmík, Jiří - Hříbková, Hana - Klímová, Hana - Váňová, Tereza - Bohačiaková, Dáša
PY - 2022
TI - Human iPSC-Derived Neural Models for Studying Alzheimer’s Disease: from Neural Stem Cells to Cerebral Organoids
JF - Stem Cell Reviews and Reports
VL - 18
IS - 2
SP - 792-820
EP - 792-820
PB - SPRINGER
SN - 26293269
KW - iPSCs
KW - Neural differentiation
KW - Alzheimer’s disease
KW - In vitro differentiation
KW - Neural stem cells
KW - Neural progenitors
KW - Neurons
KW - Astrocytes
KW - Microglia
KW - Cerebral organoids
UR - https://link.springer.com/article/10.1007/s12015-021-10254-3
N2 - During the past two decades, induced pluripotent stem cells (iPSCs) have been widely used to study mechanisms of human neural development, disease modeling, and drug discovery in vitro. Especially in the field of Alzheimer’s disease (AD), where this treatment is lacking, tremendous effort has been put into the investigation of molecular mechanisms behind this disease using induced pluripotent stem cell-based models. Numerous of these studies have found either novel regulatory mechanisms that could be exploited to develop relevant drugs for AD treatment or have already tested small molecules on in vitro cultures, directly demonstrating their effect on amelioration of AD-associated pathology. This review thus summarizes currently used differentiation strategies of induced pluripotent stem cells towards neuronal and glial cell types and cerebral organoids and their utilization in modeling AD and potential drug discovery.
ER -
BARÁK, Martin, Veronika FEDOROVÁ, Veronika POSPÍŠILOVÁ, Jan RAŠKA, Simona VOCHYÁNOVÁ, Jiří SEDMÍK, Hana HŘÍBKOVÁ, Hana KLÍMOVÁ, Tereza VÁŇOVÁ a Dáša BOHAČIAKOVÁ. Human iPSC-Derived Neural Models for Studying Alzheimer’s Disease: from Neural Stem Cells to Cerebral Organoids. \textit{Stem Cell Reviews and Reports}. NEW YORK: SPRINGER, roč.~18, č.~2, s.~792-820. ISSN~2629-3269. doi:10.1007/s12015-021-10254-3. 2022.
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