J 2022

Human iPSC-Derived Neural Models for Studying Alzheimer’s Disease: from Neural Stem Cells to Cerebral Organoids

BARÁK, Martin, Veronika FEDOROVÁ, Veronika POSPÍŠILOVÁ, Jan RAŠKA, Simona VOCHYÁNOVÁ et. al.

Basic information

Original name

Human iPSC-Derived Neural Models for Studying Alzheimer’s Disease: from Neural Stem Cells to Cerebral Organoids

Authors

BARÁK, Martin (203 Czech Republic, belonging to the institution), Veronika FEDOROVÁ (203 Czech Republic, belonging to the institution), Veronika POSPÍŠILOVÁ (203 Czech Republic, belonging to the institution), Jan RAŠKA (203 Czech Republic, belonging to the institution), Simona VOCHYÁNOVÁ (203 Czech Republic, belonging to the institution), Jiří SEDMÍK (203 Czech Republic, belonging to the institution), Hana HŘÍBKOVÁ (203 Czech Republic, belonging to the institution), Hana KLÍMOVÁ (203 Czech Republic, belonging to the institution), Tereza VÁŇOVÁ (203 Czech Republic, belonging to the institution) and Dáša BOHAČIAKOVÁ (703 Slovakia, guarantor, belonging to the institution)

Edition

Stem Cell Reviews and Reports, NEW YORK, SPRINGER, 2022, 2629-3269

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10601 Cell biology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 4.800

RIV identification code

RIV/00216224:14110/22:00125401

Organization unit

Faculty of Medicine

DOI

UT WoS

000749958800002

Keywords in English

iPSCs; Neural differentiation; Alzheimer’s disease; In vitro differentiation; Neural stem cells; Neural progenitors; Neurons; Astrocytes; Microglia; Cerebral organoids

Tags

Tags

International impact, Reviewed
Změněno: 20/2/2023 10:44, Mgr. Tereza Miškechová

Abstract

V originále

During the past two decades, induced pluripotent stem cells (iPSCs) have been widely used to study mechanisms of human neural development, disease modeling, and drug discovery in vitro. Especially in the field of Alzheimer’s disease (AD), where this treatment is lacking, tremendous effort has been put into the investigation of molecular mechanisms behind this disease using induced pluripotent stem cell-based models. Numerous of these studies have found either novel regulatory mechanisms that could be exploited to develop relevant drugs for AD treatment or have already tested small molecules on in vitro cultures, directly demonstrating their effect on amelioration of AD-associated pathology. This review thus summarizes currently used differentiation strategies of induced pluripotent stem cells towards neuronal and glial cell types and cerebral organoids and their utilization in modeling AD and potential drug discovery.

Links

GA21-21510S, research and development project
Name: Studium molekulárních mechanismů vzniku Alzheimerovy choroby pomocí cerebrálních organoidů (Acronym: AD Brain Organoids)
Investor: Czech Science Foundation
GJ18-25429Y, research and development project
Name: Funkční studie mikroRNA u nerálních kmenových buněk v průběhu diferenciace
Investor: Czech Science Foundation
MUNI/A/1382/2019, interní kód MU
Name: Zdroje pro tkáňové inženýrství 10 (Acronym: TissueEng 10)
Investor: Masaryk University, Category A
MUNI/A/1398/2021, interní kód MU
Name: Zdroje pro tkáňové inženýrství 12 (Acronym: TissueEng 12)
Investor: Masaryk University
MUNI/A/1418/2021, interní kód MU
Name: Biomedicínské vědy II (Acronym: BIOMED)
Investor: Masaryk University
MUNI/G/1131/2017, interní kód MU
Name: Transformative stem cell-based model of Alzheimer’s disease and advanced analytics to study the role of membrane lipids in the pathogenesis
Investor: Masaryk University, INTERDISCIPLINARY - Interdisciplinary research projects
MUNI/R/1697/2020, interní kód MU
Name: Career Restart - Stem Cell-Based Models of Neurodegeneration
Investor: Masaryk University, CAREER RESTART
MUNI/11/SUP/19/2020, interní kód MU
Name: Efekt buněčného stárnutí na vznik Alzheimerovy nemoci
Investor: Masaryk University
NU21-08-00373, research and development project
Name: Patogeny indukovaná senescence jako spouštěcí faktor Alzheimerovy nemoci (Acronym: Patogeny u AD)
Investor: Ministry of Health of the CR, Subprogram 1 - standard
NV19-08-00472, research and development project
Name: Klinicky relevantní biochemické, imunologické a buněčné biomarkery Alzheimerovy nemoci a stárnutí (Acronym: BioMAD)
Investor: Ministry of Health of the CR
8F20009, research and development project
Name: Identifying and treating SORL1-associated Alzheimer’s disease (Acronym: SORLA - FIX)
Investor: Ministry of Education, Youth and Sports of the CR, Neurodegenerative Disease (JPND)