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@inbook{1835097, author = {Bárta, Tomáš and Bohačiaková, Dáša and Čajánek, Lukáš}, booktitle = {Recent Advances in iPSC Technology}, doi = {http://dx.doi.org/10.1016/B978-0-12-822231-7.00007-2}, keywords = {Cell cycle; Checkpoint; Differentiation; Growth factor; Noncoding RNA; Pluripotency; Proliferation; Reprogramming; Self-renewal; Signaling; Stem cell; Telomereses}, isbn = {978-0-12-822231-7}, pages = {179-207}, title = {Self-renewal in induced pluripotent stem cells}, url = {https://www.sciencedirect.com/science/article/pii/B9780128222317000072}, year = {2021} }
TY - CHAP ID - 1835097 AU - Bárta, Tomáš - Bohačiaková, Dáša - Čajánek, Lukáš PY - 2021 TI - Self-renewal in induced pluripotent stem cells SN - 9780128222317 KW - Cell cycle KW - Checkpoint KW - Differentiation KW - Growth factor KW - Noncoding RNA KW - Pluripotency KW - Proliferation KW - Reprogramming KW - Self-renewal KW - Signaling KW - Stem cell KW - Telomereses UR - https://www.sciencedirect.com/science/article/pii/B9780128222317000072 N2 - Human induced pluripotent stem cells (hiPSCs) hold great promise in the fields of regenerative medicine and disease modeling. In order to fully exploit the regenerative potential of hiPSCs through efficient, safe, and cost-effective production and maintenance of these cells, it is vital to have a firm understanding of the molecular processes responsible for their unique properties. hiPSCs rely on mechanisms similar to those in human embryonic stem cells to maintain their pluripotency and to control their differentiation (Vallier et al., 2009). In this chapter, we thoroughly discuss the current understanding of the key players and principles orchestrating effective self-renewal of hiPSCs, namely the mechanisms and consequences of cell cycle regulation and the role of growth factors, noncoding RNAs, and telomeres. ER -
BÁRTA, Tomáš, Dáša BOHAČIAKOVÁ and Lukáš ČAJÁNEK. Self-renewal in induced pluripotent stem cells. In \textit{Recent Advances in iPSC Technology}. 2021, p.~179-207, 28 pp. ISBN~978-0-12-822231-7. Available from: https://dx.doi.org/10.1016/B978-0-12-822231-7.00007-2.
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