C 2021

Self-renewal in induced pluripotent stem cells

BÁRTA, Tomáš, Dáša BOHAČIAKOVÁ and Lukáš ČAJÁNEK

Basic information

Original name

Self-renewal in induced pluripotent stem cells

Name (in English)

Self-renewal in induced pluripotent stem cells

Authors

Edition

Recent Advances in iPSC Technology, p. 179-207, 28 pp. 2021

Other information

Type of outcome

Kapitola resp. kapitoly v odborné knize

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

ISBN

978-0-12-822231-7

DOI

Keywords in English

Cell cycle; Checkpoint; Differentiation; Growth factor; Noncoding RNA; Pluripotency; Proliferation; Reprogramming; Self-renewal; Signaling; Stem cell; Telomereses

Tags

International impact
Změněno: 17/2/2022 14:40, Ing. Nicole Ludikovská

Abstract

ORIG EN

V originále

Human induced pluripotent stem cells (hiPSCs) hold great promise in the fields of regenerative medicine and disease modeling. In order to fully exploit the regenerative potential of hiPSCs through efficient, safe, and cost-effective production and maintenance of these cells, it is vital to have a firm understanding of the molecular processes responsible for their unique properties. hiPSCs rely on mechanisms similar to those in human embryonic stem cells to maintain their pluripotency and to control their differentiation (Vallier et al., 2009). In this chapter, we thoroughly discuss the current understanding of the key players and principles orchestrating effective self-renewal of hiPSCs, namely the mechanisms and consequences of cell cycle regulation and the role of growth factors, noncoding RNAs, and telomeres.

In English

Human induced pluripotent stem cells (hiPSCs) hold great promise in the fields of regenerative medicine and disease modeling. In order to fully exploit the regenerative potential of hiPSCs through efficient, safe, and cost-effective production and maintenance of these cells, it is vital to have a firm understanding of the molecular processes responsible for their unique properties. hiPSCs rely on mechanisms similar to those in human embryonic stem cells to maintain their pluripotency and to control their differentiation (Vallier et al., 2009). In this chapter, we thoroughly discuss the current understanding of the key players and principles orchestrating effective self-renewal of hiPSCs, namely the mechanisms and consequences of cell cycle regulation and the role of growth factors, noncoding RNAs, and telomeres.