BÁRTA, Tomáš, Dáša BOHAČIAKOVÁ and Lukáš ČAJÁNEK. Self-renewal in induced pluripotent stem cells. In Recent Advances in iPSC Technology. 2021, p. 179-207, 28 pp. ISBN 978-0-12-822231-7. Available from: https://dx.doi.org/10.1016/B978-0-12-822231-7.00007-2.
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Basic information
Original name Self-renewal in induced pluripotent stem cells
Name (in English) Self-renewal in induced pluripotent stem cells
Authors BÁRTA, Tomáš, Dáša BOHAČIAKOVÁ and Lukáš ČAJÁNEK.
Edition Recent Advances in iPSC Technology, p. 179-207, 28 pp. 2021.
Other information
Type of outcome Chapter(s) of a specialized book
Confidentiality degree is not subject to a state or trade secret
WWW URL
ISBN 978-0-12-822231-7
Doi http://dx.doi.org/10.1016/B978-0-12-822231-7.00007-2
Keywords in English Cell cycle; Checkpoint; Differentiation; Growth factor; Noncoding RNA; Pluripotency; Proliferation; Reprogramming; Self-renewal; Signaling; Stem cell; Telomereses
Tags International impact
Changed by Changed by: Ing. Nicole Ludikovská, učo 358847. Changed: 17/2/2022 14:40.
Abstract
Human induced pluripotent stem cells (hiPSCs) hold great promise in the fields of regenerative medicine and disease modeling. In order to fully exploit the regenerative potential of hiPSCs through efficient, safe, and cost-effective production and maintenance of these cells, it is vital to have a firm understanding of the molecular processes responsible for their unique properties. hiPSCs rely on mechanisms similar to those in human embryonic stem cells to maintain their pluripotency and to control their differentiation (Vallier et al., 2009). In this chapter, we thoroughly discuss the current understanding of the key players and principles orchestrating effective self-renewal of hiPSCs, namely the mechanisms and consequences of cell cycle regulation and the role of growth factors, noncoding RNAs, and telomeres.
Abstract (in English)
Human induced pluripotent stem cells (hiPSCs) hold great promise in the fields of regenerative medicine and disease modeling. In order to fully exploit the regenerative potential of hiPSCs through efficient, safe, and cost-effective production and maintenance of these cells, it is vital to have a firm understanding of the molecular processes responsible for their unique properties. hiPSCs rely on mechanisms similar to those in human embryonic stem cells to maintain their pluripotency and to control their differentiation (Vallier et al., 2009). In this chapter, we thoroughly discuss the current understanding of the key players and principles orchestrating effective self-renewal of hiPSCs, namely the mechanisms and consequences of cell cycle regulation and the role of growth factors, noncoding RNAs, and telomeres.
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